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Taletrectinib
go.drugbank.com/drugs/DB18711ApprovedInvestigational[A274158] As part of the second-generation of ROS1 inhibitors, taletrectinib is significantly more potent against ROS1 resistance mutations - for example, the IC50 for taletrectinib against ROS1 exhibiting … the secondary solvent-front mutation _G2032R_ is 400-times lower than that of the previously approved first-generation inhibitors [crizotinib] and [entrectinib].
Categories: MATE 1 Substrates, MATE 2 InhibitorsEncorafenib
go.drugbank.com/drugs/DB11718ApprovedInvestigationalMutations in this gene, most frequently the V600E mutation, are the most commonly identified cancer-causing mutations in melanoma, and have been isolated in various other cancers as well, including non-Hodgkin … [L12216] This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which impacts cell division, differentiation, and secretion.
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesProducts: BRAFTOVI® 75 MG CÁPSULASSugammadex
go.drugbank.com/drugs/DB06206ApprovedInvestigationalSugammadex provides a new treatment option to reverse the effects of those medications and possibly help patients recover sooner post-surgery. … Sugammadex (brand name Bridion) is marketed by Merck Sharp and Dohme, and was approved by the United States FDA on December 15, 2015.
Categories: Compounds used in a research, industrial, or household settingProducts: BRIDION® 200 MG/2 ML SOLUCIÓN PARA INYECCIÓN, MIGAD-XCoronavirus Disease 2019 (COVID‑19)
go.drugbank.com/conditions/DBCOND0129755Drugs: Anakinra · Andusomeran · AstraZeneca COVID-19 Vaccine · BNT162B2 Omicron (LP.8.1) · Baricitinib · CX-046684 +26 moreFurazolidone
go.drugbank.com/drugs/DB00614InvestigationalVet approvedA nitrofuran derivative with antiprotozoal and antibacterial activity. Furazolidone binds bacterial DNA which leads to the gradual inhibition of monoamine oxidase. … (From Martindale, The Extra Pharmacopoeia, 30th ed, p514)
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome, Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substratesSynonyms: 5-Nitro-N-(2-oxo-3-oxazolidinyl)-2-furanmethanimine, N-(5-Nitro-2-furfurylidene)-3-amino-2-oxazolidonePimecrolimus
go.drugbank.com/drugs/DB00337ApprovedInvestigationalIt is currently available as a topic cream used in the treatment of atopic dermatitis (eczema). … Pimecrolimus is an immunomodulating agent that was first marketed by Novartis under the trade name Elidel. It is now promoted in Canada by Galderma since early 2007.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesProducts: ELIDEL CREAM 1% w/w, ELIDEL® 1% CREMAInfluenza B virus B/Michigan/01/2021 antigen (formaldehyde inactivated)
go.drugbank.com/drugs/DB16917ApprovedA seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that helps to protect against infection from influenza viruses. … Upon re-exposure to an influenza virus, the immune system is prepared with circulating antibodies that identify and destroy the virus.
Mixtures: Fluzone Qiv Sh 2025, Fluzone QIV SH 2025Categories: Inactivated Influenza B Virus VaccineDeserpidine
go.drugbank.com/drugs/DB01089ApprovedWithdrawnDeserpidine is an ester alkaloid drug isolated from Rauwolfia canescens (family Apocynaceae) with antipsychotic and antihypertensive properties that has been used for the control of high blood pressure … and for the relief of psychotic behavior.
Categories: Heterocyclic Compounds, 2-RingOuabain
go.drugbank.com/drugs/DB01092ApprovedIt is commonly used in cell biological studies as an inhibitor of the NA(+)-K(+)-exchanging ATPase. … A cardioactive glycoside consisting of rhamnose and ouabagenin, obtained from the seeds of Strophanthus gratus and other plants of the Apocynaceae; used like digitalis.
Categories: g-strophanthin, Compounds used in a research, industrial, or household settingSynonyms: 3-(α-L-rhamnopyranosyloxy)-1β,5β,11α,14,19-pentahydroxy-5β-card-20(22)-enolide, G-StrophanthinCabozantinib
go.drugbank.com/drugs/DB08875ApprovedInvestigationalIt was initially approved in the US under the brand name Cometriq, which is indicated for the treatment of metastatic medullary thyroid cancer. … [L15123] In 2016, a capsule formulation (Cabometyx) was approved for the treatment of advanced renal cell carcinoma, and this same formulation gained additional approval in both the US and Canada in 2019
Categories: Cytochrome P-450 CYP2C9 Substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index