Search
Dimethylthiambutene Action Pathway
smpdb.ca/view/SMP0000680Drug actionG(i) protein can also open potassium channels and close calcium channels to result in hyperpolarize on neuron. … Dimethylthiambutene (also known as Ohton or Aminobutene) is an opioid analgesic and substrate for mu-type opioid receptor which can be used for relieving pain.
Enzymes: Sodium channel subunit beta-1, Sodium-dependent serotonin transporterNaloxone Action Pathway
smpdb.ca/view/SMP0000688Drug actionIn recent study, naloxone shows that it can also bind to kappa and gamma-opioid receptors.
Enzymes: Sodium channel subunit beta-1, Sodium-dependent serotonin transporterHydromorphone Action Pathway
smpdb.ca/view/SMP0000410Drug actionThe binding of hydromorphone will eventually lead to reduced pain because of decreased nerve conduction and release of neurotransmitter. … Hyperpolarization of neuron is caused by inactivation of calcium channels and activation of potassium channels via facilitated by G-protein.
Enzymes: Sodium channel subunit beta-1, Sodium-dependent serotonin transporterHydrocodone Action Pathway
smpdb.ca/view/SMP0000411Drug actionThe binding of hydrocodone will eventually lead to reduced pain because of decreased nerve conduction and release of neurotransmitter. … Hyperpolarization of neuron is caused by inactivation of calcium channels and activation of potassium channels via facilitated by G-protein.
Enzymes: Sodium channel subunit beta-1, Sodium-dependent serotonin transporterAlfentanil Action Pathway
smpdb.ca/view/SMP0000413Drug actionThe binding of alfentanil will eventually lead to reduced pain because of decreased nerve conduction and release of neurotransmitter. … Hyperpolarization of neuron is caused by inactivation of calcium channels and activation of potassium channels via facilitated by G-protein.
Enzymes: Sodium channel subunit beta-1, Sodium-dependent serotonin transporterSufentanil Action Pathway
smpdb.ca/view/SMP0000417Drug actionand decrease in cAMP production. … It also inhibits nociceptive neurotransmitter release and induces membrane hyperpolarization. Analgesia, anesthesia, and respiratory depression are a consequence of remifentanial’s action.
Enzymes: Sodium channel subunit beta-1, Sodium-dependent serotonin transporterPropoxyphene Action Pathway
smpdb.ca/view/SMP0000672Drug actionOpioids inhibit vasopressin, somatostatin, insulin and glucagon release. … Propoxyphene also causes the closure of voltage-gated calcium channels and opens potassium channels causing the hyperpolarization of the membrane and decreasing neuronal excitability.
Enzymes: Sodium channel subunit beta-1, Sodium-dependent serotonin transporterLevorphanol Action Pathway
smpdb.ca/view/SMP0000673Drug actionThe binding of levorphanol will eventually lead to reduced pain because of decreased nerve conduction and release of neurotransmitter. … Therefore, levorphanol can reduce nerve conduction and decrease neurotransmitter release; so that perception of pain signals can be blocked.
Enzymes: Sodium channel subunit beta-1, Sodium-dependent serotonin transporterAnileridine Action Pathway
smpdb.ca/view/SMP0000674Drug actionThe binding of anileridine will eventually lead to reduced pain because of decreased nerve conduction and release of neurotransmitter. … Hyperpolarization of neuron is caused by inactivation of calcium channels and activation of potassium channels via facilitated by G-protein.
Enzymes: Sodium channel subunit beta-1, Sodium-dependent serotonin transporterMethadyl Acetate Action Pathway
smpdb.ca/view/SMP0000678Drug actionThe binding of methadyl acetate will eventually lead to reduced pain because of decreased nerve conduction and release of neurotransmitter. … Therefore, methadyl acetate can reduce nerve conduction and decrease neurotransmitter release; so that perception of pain signals can be blocked.
Enzymes: Sodium channel subunit beta-1, Sodium-dependent serotonin transporter