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Procaine Action Pathway
smpdb.ca/view/SMP0000402Drug actionProcaine exerts its local anaesthetic effect by blocking voltage-gated sodium channels in peripheral neurons. Procaine diffuses across the neuronal plasma membrane in its uncharged base form. Once inside the cytoplasm, it is protonated a...
Hydromorphone Action Pathway
smpdb.ca/view/SMP0000410Drug actionHydromorphone (also known as dihydromorphinone or Dilaudid) is analgesic that can bind to mu-type opioid receptor to activate associated G-protein in the sensory neurons of central nervous system (CNS), which will reduce the level of int...
Hydrocodone Action Pathway
smpdb.ca/view/SMP0000411Drug actionHydrocodone (also known as Vicodin or Norco) is analgesic that can bind to mu-type opioid receptor to activate associated G-protein in the sensory neurons of central nervous system (CNS), which will reduce the level of intracellular cAMP...
Alfentanil Action Pathway
smpdb.ca/view/SMP0000413Drug actionAlfentanil (also known as Alfenta or Rapifen) is analgesic that can bind to mu-type opioid receptor to activate associated G-protein in the sensory neurons of central nervous system (CNS), which will reduce the level of intracellular cAM...
Sufentanil Action Pathway
smpdb.ca/view/SMP0000417Drug actionSufentanil is a pharmacologically-active synthetic small molecule derived from fentanyl and belongs to a class of drugs called opioids. Opioids are therapeutically employed to achieve analgesia. Sufentanil’s rapid mechanism of action pri...
Escitalopram Action Pathway
smpdb.ca/view/SMP0000425Drug actionEscitalopram is a selective serotonin reuptake inhibitor that exerts antidepressive effects by selectively inhibiting serotonin reuptake in the brain. It does so by competing for the same binding site as serotonin on the the sodium-depen...
Propoxyphene Action Pathway
smpdb.ca/view/SMP0000672Drug actionPropoxyphene is an analgesic in the opioid category. It primarily acts on the G protein coupled receptors, OP3. Propoxyphene binding to OP3 causes GTP exchange for GDP and inhibit adenylate cyclase causing decreased intracellular cAMP. T...
Levorphanol Action Pathway
smpdb.ca/view/SMP0000673Drug actionLevorphanol (also known as Levo-Dromoran) is an opioid medication that can bind to mu-type opioid receptor to activate associated G-protein in the sensory neurons of central nervous system (CNS), which will reduce the level of intracellu...
Anileridine Action Pathway
smpdb.ca/view/SMP0000674Drug actionAnileridine (also known as Leritine) is analgesic that can bind to mu-type opioid receptor to activate associated G-protein in the sensory neurons of central nervous system (CNS), which will reduce the level of intracellular cAMP by inhi...
Ethylmorphine Action Pathway
smpdb.ca/view/SMP0000681Drug actionEthylmorphine (also known as codethyline and dionine) is an opioid analgesic. Ethylmorphine can be metabolized to form morphine by cytochrome P450 2D6 (CYP2D6). Morphine can bind the mu-type opioid receptor on central nervous system (CNS...