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Displaying results 4331 - 4340 of 10000 in total
  1. Target

    Gamma-aminobutyric acid receptor subunit alpha-6

    go.drugbank.com/bio_entities/BE0000764
    TargetHumans

    Extrasynaptic alpha-6-containing receptors contribute to the tonic GABAergic inhibition. Alpha-6 subunits are also present on glutamatergic synapses (By similarity) … Alpha-6/GABRA6 subunits are found at both synaptic and extrasynaptic sites (PubMed:8632757).

    Polypeptides: Gamma-aminobutyric acid receptor subunit alpha-6Synonyms: GABAAR subunit alpha-6, GABA(A) receptor subunit alpha-6
  2. Target

    Putative glycosyltransferase 6 domain-containing protein 1

    go.drugbank.com/bio_entities/BE0004501
    TargetHumans

    Polypeptides: Putative glycosyltransferase 6 domain-containing protein 1Synonyms: Galactosyltransferase family 6 domain-containing 1
  3. Target

    Tumor necrosis factor-inducible gene 6 protein

    go.drugbank.com/bio_entities/BE0004952
    TargetHumans

    Major regulator of extracellular matrix organization during tissue remodeling (PubMed:15917224, PubMed:18042364, PubMed:26823460). Catalyzes the transfer of a heavy chain (HC) from inter-alpha-inhibitor (I-alpha-I) complex to hyaluronan....

    Polypeptides: Tumor necrosis factor-inducible gene 6 proteinSynonyms: TSG-6, TNF alpha-induced protein 6
  4. Target

    Insulin-like growth factor-binding protein 6

    go.drugbank.com/bio_entities/BE0009662
    CarrierHumans

    IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Act...

    Polypeptides: Insulin-like growth factor-binding protein 6Synonyms: IBP-6, IGFBP-6
  5. Target

    Tyrosine-protein phosphatase non-receptor type 6

    go.drugbank.com/bio_entities/BE0009941
    TargetHumans

    Modulates the signaling of several cytokine receptors including IL-4 receptor (PubMed:9065461).

    Polypeptides: Tyrosine-protein phosphatase non-receptor type 6
  6. Target

    Tumor necrosis factor ligand superfamily member 6

    go.drugbank.com/bio_entities/BE0010499
    TargetHumans

    Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells (PubMed:26334989, PubMed:9228058). Involved in cytotoxic T-cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell devel...

    Polypeptides: Tumor necrosis factor ligand superfamily member 6
  7. Target

    Very long chain fatty acid elongase 6

    go.drugbank.com/bio_entities/BE0019860
    EnzymeHumans

    Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- a...

    Polypeptides: Very long chain fatty acid elongase 6Synonyms: ELOVL FA elongase 6, ELOVL fatty acid elongase 6
  8. Drug

    Tetryzoline

    go.drugbank.com/drugs/DB06764
    Approved

    Tetryzoline is found in a wide array of over-the-counter eye drops, including the most common brand, Visine. … [A231769] Available since the 1950s, tetryzoline is a selective α<sub>1</sub>-receptor agonist [A231774] that is used as an ocular and nasal decongestant.

    Mixtures: EFEMOLINE 5 ML DAMLA, Rohto All-In-OneCategories: Compounds used in a research, industrial, or household setting, Adrenergic alpha-1 Receptor Agonists
  9. Drug

    Morphine

    go.drugbank.com/drugs/DB00295
    ApprovedInvestigational

    Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805.[A176035] It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. … [A176050] Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as [codeine], [fentanyl], [methadone], [hydrocodone], [hydromorphone], [meperidine

    Categories: Cytochrome P-450 Substrates, P-glycoprotein substratesSynonyms: (5R,6S,9R,13S,14R)-4,5-epoxy-N-methyl-7-morphinen-3,6-diol, (7R,7AS,12bs)-3-methyl-2,3,4,4a,7,7a-hexahydro-1H-4,12-methano[1]benzofuro[3,2-e]isoquinoline-7,9-diol
  10. Target

    Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2

    go.drugbank.com/bio_entities/BE0002238
    EnzymeHumans

    Rate-limiting enzyme of the hexosamine biosynthetic pathway (HBP) that catalyzes the formation of glucosamine-6-phosphate from fructose-6-phosphate and glutamine, thereby controlling the flux of glucose

    Polypeptides: Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2Synonyms: D-fructose-6-phosphate amidotransferase 2, Glutamine:fructose-6-phosphate amidotransferase 2