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Displaying results 431 - 440 of 10000 in total
  1. Drug

    Hyaluronic acid

    go.drugbank.com/drugs/DB08818
    ApprovedInvestigationalVet approved

    A popular use of hyaluronic acid in recent years is cosmetic injection due to its ability to minimize the appearance of wrinkles and aging-related skin imperfections.[L32193] … Hyaluronic acid (HA) is an anionic, nonsulfated glycosaminoglycan found in connective, epithelial, and neural tissues; it was first isolated in 1934.

    Categories: Compounds used in a research, industrial, or household settingProducts: SYNOLIS V-A, TRANEN AT
  2. Drug

    Xipamide

    go.drugbank.com/drugs/DB13803
    Investigational

    Products: XIPAMID AL 10MG, XIPAMID AL 20MG
  3. Pathway

    Intracellular Signalling Through Prostacyclin Receptor and Prostacyclin

    smpdb.ca/view/SMP0000354
    Signaling

    The receptor is a G-protein coupled receptor, upon its binding it activates G proteins causing the activation of adenylyl cyclase and production of cAMP messenger molecules. cAMP activates PKA (protein … Prostacyclin binding to its receptor increases vasodilation and decreases platelet aggregation.

    Drugs: ATP · Calcium · Magnesium cation · Cyclic adenosine monophosphate · Pyrophosphoric acid
    Enzymes: Prostacyclin receptor
  4. Pathway

    Trimebutine M3 Receptor Intestine Relaxation Action Pathway

    smpdb.ca/view/SMP0126338
    Drug action

    Trimebutine is a spasmolytic agent used for the symptomatic treatment of irritable bowel syndrome (IBS) and treatment of postoperative paralytic ileus following abdominal surgery. Trimebutine is a spasmolytic agent that regulates intesti...

    Drugs: ATP · Nitric Oxide · Potassium cation · Calcium · Magnesium cation · Cyclic adenosine monophosphate +3 more
    Enzymes: Mu-type opioid receptor, Muscarinic acetylcholine receptor M3
  5. Drug

    Letrozole

    go.drugbank.com/drugs/DB01006
    ApprovedInvestigational

    Letrozole, or CGS 20267, is an oral non-steroidal type II aromatase inhibitor first described in the literature in 1990. … [A190543,A1559,L11623,L11626] It is a third generation aromatase inhibitor like [exemestane] and [anastrozole], meaning it does not significantly affect cortisol, aldosterone, and thyroxine.

    Products: Ag-letrozole, Ag-letrozole Tablets
  6. Drug

    Pentoxifylline

    go.drugbank.com/drugs/DB00806
    ApprovedInvestigational

    [A226410, A226415, A226455] More recently, PTX has been suggested as a possible treatment for COVID-19-induced pulmonary complications due to its ability to regulate the production of inflammatory cytokines … Pentoxifylline (PTX) is a synthetic dimethylxanthine derivative that modulates the rheological properties of blood and also has both anti-oxidant and anti-inflammatory properties.

    International brands: Ao Le Ni, An Ruo NingCategories: Compounds used in a research, industrial, or household setting
  7. Drug

    Melperone

    go.drugbank.com/drugs/DB09224
    Investigational

    Recently, it has been studied as a treatment of psychosis related to Parkinson's disease [L1316]. … It has been well established in the treatment of confusion, anxiety, restlessness (particularly in the elderly) and schizophrenia as It is known to be well-tolerated with an excellent safety profile.

    Categories: Dopamine D2 Receptor AntagonistsProducts: MELPERON AL 25, MELPERON AL 100
  8. Drug

    WU-CART-007

    go.drugbank.com/drugs/DB18617
    Investigational

    WU-CART-007 consists of allogeneic, fratricide-resistant genetically modified T cells transduced with a 2nd generation 4-1BB-CD3z chimeric antigen receptor targeting human CD7.

    Synonyms: an allogeneic, fratricide-resistant genetically modified T cell transduced with a 2nd generation 4-1BB-CD3z chimeric antigen receptor targeting human CD7
  9. Drug

    Vinorelbine

    go.drugbank.com/drugs/DB00361
    ApprovedInvestigational

    It is a third-generation vinca alkaloid. … A study was done on the clearance rate of vinorelbine on individuals with various single polymorphonuclear mutations.

    Categories: Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic IndexProducts: Aj-vinorelbine
  10. Drug

    Candesartan cilexetil

    go.drugbank.com/drugs/DB00796
    ApprovedInvestigational

    Candesartan is an angiotensin-receptor blocker (ARB) that may be used alone or with other agents to treat hypertension. … It may also be used as an alternative agent for the treatment of heart failure, systolic dysfunction, myocardial infarction and coronary artery disease.

    Mixtures: Ag-candesartan HCT, Ag-candesartan HCTCategories: Angiotensin 2 Receptor Blocker, Angiotensin Receptor Antagonists