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Stiripentol
go.drugbank.com/drugs/DB09118ApprovedInvestigational[A19739] Approved in the US, Canada, and Europe, stiripentol is used to treat seizures associated with Dravet syndrome.[L880,L42500,L42510] It is marketed under the brand name Diacomit. … [A19740, A250825] The clinical development and marketing of stiripentol were first delayed due to the drug's potent inhibitory effects on hepatic cytochrome P450 (CYP) enzymes.
Categories: Cytochrome P-450 CYP1A2 Inducers, P-glycoprotein inhibitorsSynonyms: 1-(1,3-Benzodioxol-5-yl)-4,4-dimethyl-1-penten-3-ol, 4,4-Dimethyl-1-((3,4-methylenedioxy)phenyl)-1-penten-3-olNipocalimab
go.drugbank.com/drugs/DB16257ApprovedInvestigational[L64042] It is an aglycosylated, fully human IgG1 monoclonal antibody that binds FcRn and blocks the receptor's recycling of immunoglobulin G (IgG), thereby lowering circulating IgG levels, including pathogenic … Nipocalimab-aahu is a neonatal Fc receptor (FcRn) blocker used to treat certain antibody-mediated autoimmune diseases.
Synonyms: immunoglobulin G1-lambda, anti-[Homo sapiens FCGRT (Fc fragment of IgG receptor and transporter, neonatal Fc receptor, FcRn, transmembrane alpha chain of the neonatal receptor)], Homo sapiens monoclonal, antibody (gamma1 heavy chain Homo sapiens (1-445)Ditiocarb zinc
go.drugbank.com/drugs/DB14193ApprovedDitiocarb zinc, also known as Diethyldithiocarbamic acid zinc salt, is a known chelator for copper and zinc. It also a dermatological sensitizer and allergen. … Sensitivity to ditiocarb zinc may be identified with a clinical patch test.
Categories: Compounds used in a research, industrial, or household setting, Agents for Treatment of Hemorrhoids and Anal Fissures for Topical UseSynonyms: Zinc N,N-diethyldithiocarbamate, Zinc, bis(diethylcarbamodithioato-S,S')-Thioguanine Action Pathway (old)
smpdb.ca/view/SMP0000430Drug actionOnce in a cell, thioguanine is converted to thioguanosine monophosphate by hypoxanthine-guanine phosphoribosyltransferase. … The thioguanosine triphosphate metabolite also inhibits Ras-related C3 botulinum toxin substrate 1, a plasma membrane-associated small GTPase that regulates cellular processes, inducing apoptosis in activated
Drugs: Tetrahydrofolic acid · Ademetionine · Aspartic acid · L-Glutamine · Adenosine phosphate · Glutamic acid +27 moreCholine salicylate
go.drugbank.com/drugs/DB14006ApprovedNutraceuticalThis drug is also a main ingredient in teething gels to relieve pains associated with tooth growth in the infant population [L2134]. … The UK government has regulated its use, due to toxicity in those under 16 years of age.
Products: DENCOL JEL SPREY, 20 G, Colident %8.71 jel sprey, 20 G3,3'-diindolylmethane
go.drugbank.com/drugs/DB11875InvestigationalDiindolylmethane has been used in trials studying the prevention and treatment of SLE, Prostate Cancer, Cervical Dysplasia, Stage I Prostate Cancer, and Stage II Prostate Cancer, among others.
Categories: Compounds used in a research, industrial, or household setting, Heterocyclic Compounds, 2-RingAdrenoleukodystrophy, X-Linked
smpdb.ca/view/SMP0000516DiseaseSeizures are a typical symptom in many affected individuals in the the end stages of the disease progression. … Loss of vision is an early finding in some patients and is a prominent feature at some stage in most affected individuals.
Enzymes: Carnitine O-acetyltransferase, Peroxisomal carnitine O-octanoyltransferaseCarnitine-Acylcarnitine Translocase Deficiency
smpdb.ca/view/SMP0000517DiseaseIndividuals with CACT deficiency also usually have excess ammonia in the blood (hyperammonemia), an enlarged liver (hepatomegaly), and a weakened heart muscle (cardiomyopathy). … Others who are afflicted with a milder form of the disorder develop signs and symptoms in early childhood and are at risk for nervous system damage, liver failure, coma, and death.
Enzymes: Carnitine O-acetyltransferase, Peroxisomal carnitine O-octanoyltransferaseAdrenoleukodystrophy, X-Linked
smpdb.ca/view/SMP0125745DiseaseSeizures are a typical symptom in many affected individuals in the the end stages of the disease progression. … Loss of vision is an early finding in some patients and is a prominent feature at some stage in most affected individuals.
Enzymes: Carnitine O-acetyltransferase, Peroxisomal carnitine O-octanoyltransferase