Search
Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
go.drugbank.com/bio_entities/BE0002252TargetHumansMembrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to
Synonyms: Succinate dehydrogenase complex subunit DProteasome subunit alpha type-1
go.drugbank.com/bio_entities/BE0003910TargetHumansComponent of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. … This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex)
Synonyms: Multicatalytic endopeptidase complex subunit C2Proteasome subunit beta type-9
go.drugbank.com/bio_entities/BE0004737TargetHumansThe proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic
Synonyms: Multicatalytic endopeptidase complex chain 7Lysine-specific histone demethylase 1A
go.drugbank.com/bio_entities/BE0010091TargetHumansComponent of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development (PubMed:16079794, PubMed:16140033
Synonyms: BRAF35-HDAC complex protein BHC110ATPase GET3
go.drugbank.com/bio_entities/BE0000750TargetHumansThis complex then targets to the endoplasmic reticulum by membrane-bound receptors GET1/WRB and CAMLG/GET2, where the tail-anchored protein is released for insertion.
Synonyms: Transmembrane domain recognition complex 40 kDa ATPase subunitCyclin-dependent kinase 7
go.drugbank.com/bio_entities/BE0001913TargetHumansCatalytic subunit of the CDK-activating kinase (CAK) complex, a master regulator of CDK activity by catalyzing the activating threonine phosphorylation of CDKs (PubMed:41100585). … Initiates transcription by RNA polymerase II by mediating phosphorylation of POLR2A at 'Ser-5' of the repetitive C-terminal domain (CTD) when POLR2A is in complex with DNA, promoting dissociation from
Synonyms: TFIIH basal transcription factor complex kinase subunitHeat shock 70 kDa protein 13
go.drugbank.com/bio_entities/BE0008957TargetHumansHas peptide-independent ATPase activity
Synonyms: Microsomal stress-70 protein ATPase coreRunt-related transcription factor 1
go.drugbank.com/bio_entities/BE0010423TargetHumansForms the heterodimeric complex core-binding factor (CBF) with CBFB. … RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their
Synonyms: Core-binding factor subunit alpha-2, SL3/AKV core-binding factor alpha B subunitProtein S100-A8
go.drugbank.com/bio_entities/BE0008955TargetHumansActivates NADPH-oxidase by facilitating the enzyme complex assembly at the cell membrane, transferring arachidonic acid, an essential cofactor, to the enzyme complex and S100A8 contributes to the enzyme … The iNOS-S100A8/A9 transnitrosylase complex directs selective inflammatory stimulus-dependent S-nitrosylation of GAPDH and probably multiple targets such as ANXA5, EZR, MSN and VIM by recognizing a [IL
Synonyms: Leukocyte L1 complex light chainBaculoviral IAP repeat-containing protein 2
go.drugbank.com/bio_entities/BE0010675TargetHumansProtects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner.
Synonyms: TNFR2-TRAF-signaling complex protein 2