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Carboprost tromethamine Action Pathway
smpdb.ca/view/SMP0127007Drug actionCarboprost tromethamine is a medication primarily used in obstetrics and gynecology for two distinct purposes. First, it is employed as an abortifacient agent in the second trimester of pregnancy, typically between the 13th and 20th week...
Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1Intracellular Signalling Through FSH Receptor and Follicle Stimulating Hormone
smpdb.ca/view/SMP0000333SignalingThe FSH receptor activates G(s) proteins which lead to the activation of Adenylyl cyclase which produces the secondary messenger cAMP. cAMP activates PKA (Protein Kinase A) which phosphorylates down stream
Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12, Guanine nucleotide-binding protein G(s) subunit alpha isoforms shortIntracellular Signalling Through LHCGR Receptor and Luteinizing Hormone/Choriogonadotropin
smpdb.ca/view/SMP0000338SignalingThe LHCGRs receptor activates G(s) proteins which lead to the activation of Adenylyl cyclase which produces the secondary messenger cAMP. cAMP activates PKA (Protein Kinase A) which phosphorylates down
Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12, Guanine nucleotide-binding protein G(s) subunit alpha isoforms shortIntracellular Signalling Through Prostacyclin Receptor and Prostacyclin
smpdb.ca/view/SMP0000354SignalingCyclooxygenase is the major producer of prostacyclin. Prostacyclin binding to its receptor increases vasodilation and decreases platelet aggregation. The receptor is a G-protein coupled receptor, upon its binding it activates G proteins ...
Enzymes: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12Dinoprostone Action Pathway
smpdb.ca/view/SMP0127013Drug actionDinoprostone is a naturally occurring prostaglandin E2 (PGE2) with significant roles in various physiological processes, most notably in labor. This medication, available as a vaginal suppository, is used for several medical purposes. Fi...
Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1Thiethylperazine Dopamine Antagonist Action Pathway
smpdb.ca/view/SMP0126476Drug actionThiethylperazine' s antipsychotic effect is due to antagonism at dopamine and serotonin type 2 receptors, with greater activity at serotonin 5-HT2 receptors than at dopamine type-2 receptors.
Drugs: Pyridoxal phosphate · Tyrosine · Sapropterin · Thiethylperazine · Dopamine · Levodopa +2 moreEnzymes: Guanine nucleotide-binding protein G(s) subunit alpha isoforms shortDopamine Activation of Neurological Reward System
smpdb.ca/view/SMP0000308SignalingIn the nervous system, dopamine acts as a neurotransmitter with roles in motor control, motivation, arousal, cognition, and reward. The mesolimbic pathway is the main pathway associated with reward, and the dopaminergic neurons of this p...
Enzymes: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12Salbutamol Action Pathway
smpdb.ca/view/SMP0126574Drug actionThe R-isomer has 150 times greater affinity for the beta2-receptor than the S-isomer and the S-isomer has been associated with toxicity. … Salbutamol is formulated as a racemic mixture of the R- and S-isomers.
Drugs: ATP · Albuterol · Potassium cation · Calcium · Magnesium cation · Cyclic adenosine monophosphateEnzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12Muscular Gq Protien Cascade
smpdb.ca/view/SMP0126980PhysiologicalG proteins, also known as guanine nucleotide-binding proteins, are a family of proteins that act as molecular switches inside cells, and are involved in transmitting signals from a variety of stimuli outside a cell to its interior. Their...
Drugs: CalciumEnzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms shortPropranolol B2-Adrenergic Vasoconstriction Action Pathway
smpdb.ca/view/SMP0126650Drug actionOrganization's List of Essential Medicines and a prototypical drug of its class, propranolol is a non-cardioselective beta blocker and it is typically synthesized as a racemic mixture of 2 enantiomers where the S(
Drugs: ATP · Propranolol · Potassium cation · Calcium · Magnesium cation · Cyclic adenosine monophosphateEnzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12