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Voltage-gated inwardly rectifying potassium channel KCNH7
go.drugbank.com/bio_entities/BE0000699TargetHumansPore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel (PubMed:32723862). … Exhibits faster activation and deactivation kinetics and slow inactivation at membrane potentials positive to 240 mV, resulting in the weakest inward rectification (PubMed:32723862)
Polypeptides: Voltage-gated inwardly rectifying potassium channel KCNH7Synonyms: Ether-a-go-go-related gene potassium channel 3, Voltage-gated potassium channel subunit Kv11.3ATP-sensitive inward rectifier potassium channel 11
go.drugbank.com/bio_entities/BE0000708TargetHumansInward rectifier potassium channel that forms the pore of ATP-sensitive potassium channels (KATP), regulating potassium permeability as a function of cytoplasmic ATP and ADP concentrations in many different … Can form cardiac and smooth muscle-type KATP channels with ABCC9
Polypeptides: ATP-sensitive inward rectifier potassium channel 11Synonyms: Potassium channel, inwardly rectifying subfamily J member 11Sodium/potassium-transporting ATPase subunit alpha-1
go.drugbank.com/bio_entities/BE0000732TargetEnzymeTransporterHumansThis process maintains essential Na(+) and K(+) gradients for membrane potential and cellular function. … It undergoes ATP-driven conformational changes that allow alternating binding and release of Na(+) and K(+) ions across the membrane (PubMed:35803952).
Polypeptides: Sodium/potassium-transporting ATPase subunit alpha-1ATP-sensitive inward rectifier potassium channel 8
go.drugbank.com/bio_entities/BE0002441TargetHumansThis channel is activated by internal ATP and can be blocked by external barium (PubMed:20558321, PubMed:21836131, PubMed:24700710, PubMed:28842488). … Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it (PubMed:20558321, PubMed:21836131, PubMed:24700710, PubMed:28842488
Polypeptides: ATP-sensitive inward rectifier potassium channel 8Synonyms: Potassium channel, inwardly rectifying subfamily J member 8Sodium/potassium-transporting ATPase subunit alpha-4
go.drugbank.com/bio_entities/BE0005031TransporterHumansPlays an essential for sperm motility, capacitation, and male fertility by maintaining ionic gradients required for flagellar function and signaling (By similarity) … Transports 3 Na(+) ions out of the cell and 2 K(+) ions into the cell for each ATP hydrolyze (PubMed:16861705).
Polypeptides: Sodium/potassium-transporting ATPase subunit alpha-4Calcium-activated potassium channel subunit alpha-1
go.drugbank.com/bio_entities/BE0000553TargetHumansPotassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+) (PubMed:14523450, PubMed:29330545, PubMed:31152168). … Possibly induces sleep when activated by melatonin and through melatonin receptor MTNR1A-dependent dissociation of G-beta and G-gamma subunits, leading to increased sensitivity to Ca(2+) and reduced synaptic
Polypeptides: Calcium-activated potassium channel subunit alpha-1Synonyms: Calcium-activated potassium channel, subfamily M subunit alpha-1ATP-sensitive inward rectifier potassium channel 1
go.drugbank.com/bio_entities/BE0000644TargetTransporterHumansThis channel is activated by internal ATP and can be blocked by external barium. In the kidney, probably plays a major role in potassium homeostasis … Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it.
Polypeptides: ATP-sensitive inward rectifier potassium channel 1Synonyms: ATP-regulated potassium channel ROM-K, Potassium channel, inwardly rectifying subfamily J member 1ATP-sensitive inward rectifier potassium channel 12
go.drugbank.com/bio_entities/BE0001131TargetHumansProbably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. … Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it.
Polypeptides: ATP-sensitive inward rectifier potassium channel 12Synonyms: Potassium channel, inwardly rectifying subfamily J member 12A-type voltage-gated potassium channel KCND2
go.drugbank.com/bio_entities/BE0003603TargetHumansVoltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain. … Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient (PubMed:10551270, PubMed:11507158, PubMed:14623880, PubMed:14695263, PubMed
Polypeptides: A-type voltage-gated potassium channel KCND2Synonyms: Voltage-gated potassium channel subunit Kv4.2, Potassium voltage-gated channel subfamily D member 2A-type voltage-gated potassium channel KCND3
go.drugbank.com/bio_entities/BE0003604TargetHumansPore-forming (alpha) subunit of voltage-gated A-type potassium channels that mediates transmembrane potassium transport in excitable membranes, in brain and heart (PubMed:10200233, PubMed:17187064, PubMed … In cardiomyocytes, may generate the transient outward potassium current I(To) (By similarity).
Polypeptides: A-type voltage-gated potassium channel KCND3Synonyms: Voltage-gated potassium channel subunit Kv4.3, Potassium voltage-gated channel subfamily D member 3