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Benzquinamide H1-Antihistamine Blood Vessel Constriction Action Pathway
smpdb.ca/view/SMP0175067Drug actionBenzquinamide is a discontinued antiemetic compound with antihistaminic, mild anticholinergic, and sedative properties. The mechanism of action is not known, but presumably benzquinamide works via antagonism of muscarinic acetycholine re...
Aceprometazine H1-Antihistamine Blood Vessel Constriction Action Pathway
smpdb.ca/view/SMP0175068Drug actionAceprometazine is a is a drug with neuroleptic and anti-histamine properties. Although not widely prescribed, it is used in combination with meprobamate for the treatment of sleep disorders in France under the trade name Mepronizine. Ace...
Hyperprolinemia Type I
smpdb.ca/view/SMP0000361DiseaseHyperprolinemia type I (HPI, proline oxidase deficiency) is caused by mutation in the proline dehydrogenase gene (PRODH), which codes for proline dehydrogenase (proline oxidase). This enzyme converts proline to delta-1-pyrroline-5-carbox...
Drugs: Pyridoxal phosphate · Ademetionine · Arginine · Aspartic acid · Ornithine · Adenosine phosphate +21 moreArginine: Glycine Amidinotransferase Deficiency (AGAT Deficiency)
smpdb.ca/view/SMP0000362DiseaseArginine: Glycine Amidinotransferase Deficiency (AGAT Deficiency, Creatine Deficiency Syndrome, Creatine Deficiency due to AGAT Deficiency, GATM Deficiency) is caused by mutation in the GATM gene, which codes for L-arginine:glycine amidi...
Drugs: Pyridoxal phosphate · Ademetionine · Arginine · Aspartic acid · Ornithine · Adenosine phosphate +21 moreCreatine Deficiency, Guanidinoacetate Methyltransferase Deficiency
smpdb.ca/view/SMP0000504DiseaseGuanidinoacetate methyltransferase deficiency, also called GAMT deficiency, is a rare inborn error of metabolism (IEM) and autosomal recessive disorder of creatine metabolism caused by a defective guanidinoacetate methyltransferase (GAMT...
Drugs: Pyridoxal phosphate · Ademetionine · Arginine · Aspartic acid · Ornithine · Adenosine phosphate +21 moreHyperornithinemia with Gyrate Atrophy (HOGA)
smpdb.ca/view/SMP0000505DiseaseHyperornithinemia with gyrate atrophy (HOGA), also known as gyrate atrophy of the choroid and retina, OAT deficiency, ornithine aminotransferase deficiency, ornithine keto acid aminotransferase deficiency) is an autosomal recessive disor...
Drugs: Pyridoxal phosphate · Ademetionine · Arginine · Aspartic acid · Ornithine · Adenosine phosphate +21 moreL-Arginine:Glycine Amidinotransferase Deficiency
smpdb.ca/view/SMP0000507DiseaseArginine:glycine amidinotransferase deficiency, also called AGAT deficiency, is an extremely rare inherited inborn error of metabolism (IEM) and an autosomal recessive disorder caused by a defective arginine:glycine amidinotransferase (A...
Drugs: Pyridoxal phosphate · Ademetionine · Arginine · Aspartic acid · Ornithine · Adenosine phosphate +21 moreIsosorbide Dinitrate Action Pathway
smpdb.ca/view/SMP0125279Drug actionIsosorbide dinitrate is an organic nitrate and an antianginal drug used to treat Angina Pectoris through vasodilation. It is an active metabolite of isosorbide dinitrate. As a organic nitrate, it is a prodrug for nitric oxide, which is a...
Drugs: Nitric Oxide · Isosorbide dinitrate · Potassium cation · Calcium · Magnesium cation · Flavin adenine dinucleotide +1 moreImmunometabolism Pathway (Viral Activation)
smpdb.ca/view/SMP0125488DiseaseThe normal response to a virus infection involves viral coat proteins activating the Toll-like receptors TLR4 and TLR2 on the membranes of macrophages, T-cells and dendritic cells. In addition to this protein activation, the viral DNA (o...
Bacterial Sepsis
smpdb.ca/view/SMP0125493DiseaseBacterial sepsis begins when bacteria activate the Toll-like receptor TLR4 on the membranes of macrophages, T-cells and dendritic cells. TLR4 activates the production of interferon regulatory factor 3 (IRF3), TIR-domain-containing adapte...