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Naloxegol Action Pathway
smpdb.ca/view/SMP0126335Drug actionThe nitric oxide diffuses into the myocyte and causes muscle relaxation. The rythmic action of the neurotransmitters creates the peristalsis and the good GI transit.
Drugs: ATP · Nitric Oxide · Calcium · Magnesium cation · Cyclic adenosine monophosphate · Acetylcholine +2 moreNaldemedine Opioid Antagonist Action Pathway
smpdb.ca/view/SMP0126337Drug actionThe nitric oxide diffuses into the myocyte and causes muscle relaxation. The rythmic action of the neurotransmitters creates the peristalsis and the good GI transit.
Drugs: ATP · Nitric Oxide · Calcium · Magnesium cation · Cyclic adenosine monophosphate · Acetylcholine +2 moreAlvimopan Opioid Antagonist Action Pathway
smpdb.ca/view/SMP0126339Drug actionThe nitric oxide diffuses into the myocyte and causes muscle relaxation. The rythmic action of the neurotransmitters creates the peristalsis and the good GI transit.
Drugs: ATP · Nitric Oxide · Calcium · Magnesium cation · Cyclic adenosine monophosphate · Acetylcholine +2 moreIsosorbide Dinitrate Action Pathway
smpdb.ca/view/SMP0125279Drug actionAs a organic nitrate, it is a prodrug for nitric oxide, which is a gas that is a potent vasodilator. … It is then metabolized in the cytosol into nitric oxide by P450 enzymes, xanthine oxidoreductase (XO), glutathione-S-transferase (GST), or cytosolic aldehyde dehydrogenase isoforms.
Drugs: Nitric Oxide · Isosorbide dinitrate · Potassium cation · Calcium · Magnesium cation · Flavin adenine dinucleotide +1 moreEthambutol Action Pathway
smpdb.ca/view/SMP0718083Drug actionEthambutol is a bacteriostatic antitubercular agent whose primary action targets the unique mycobacterial cell wall. After entering Mycobacterium tuberculosis cells, ethambutol specifically inhibits arabinosyltransferase enzymes (encoded...
Enzymes: Nitric oxide synthase, induciblePyrazinamide Action Pathway
smpdb.ca/view/SMP0718082Drug actionThe pyrazinamide (PZA) pathway plays a crucial role in the treatment of Mycobacterium tuberculosis infection. Pyrazinamide is a prodrug that requires activation by the bacterial enzyme pyrazinamidase/nicotinamidase (PncA). This enzyme co...
Enzymes: Nitric oxide synthase, inducibleTrimebutine M3 Receptor Intestine Relaxation Action Pathway
smpdb.ca/view/SMP0126338Drug actionTrimebutine is a spasmolytic agent used for the symptomatic treatment of irritable bowel syndrome (IBS) and treatment of postoperative paralytic ileus following abdominal surgery. Trimebutine is a spasmolytic agent that regulates intesti...
Drugs: ATP · Nitric Oxide · Potassium cation · Calcium · Magnesium cation · Cyclic adenosine monophosphate +3 moreCinnarizine H1-Antihistamine Blood Vessel Constriction Action Pathway
smpdb.ca/view/SMP0174985Drug actionThe inhibition of nitric oxide synthesis prevents the activation of myosin light chain phosphatase. … Calcium bound calmodulin is required for the activation of the calmodulin-binding domain of nitric oxide synthase.
Enzymes: Nitric oxide synthase, endothelialCarbinoxamine H1-Antihistamine Blood Vessel Constriction Action Pathway
smpdb.ca/view/SMP0174988Drug actionThe inhibition of nitric oxide synthesis prevents the activation of myosin light chain phosphatase. … Calcium bound calmodulin is required for the activation of the calmodulin-binding domain of nitric oxide synthase.
Enzymes: Nitric oxide synthase, endothelialMethapyrilene H1-Antihistamine Blood Vessel Constriction Action Pathway
smpdb.ca/view/SMP0175000Drug actionThe inhibition of nitric oxide synthesis prevents the activation of myosin light chain phosphatase. … Calcium bound calmodulin is required for the activation of the calmodulin-binding domain of nitric oxide synthase.
Enzymes: Nitric oxide synthase, endothelial