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Voltage-dependent calcium channel gamma-2 subunit
go.drugbank.com/bio_entities/BE0005108TargetHumansRegulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deacti...
Polypeptides: Voltage-dependent calcium channel gamma-2 subunitSynonyms: TARP gamma-2, Transmembrane AMPAR regulatory protein gamma-2Serine/threonine-protein kinase tousled-like 2
go.drugbank.com/bio_entities/BE0009398TargetHumansSerine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation (PubMed:10523312, PubMed:11470414, PubMed:12660173, PubMed:12955071, PubMe...
Polypeptides: Serine/threonine-protein kinase tousled-like 2Synonyms: Tousled-like kinase 2POU domain, class 2, transcription factor 1
go.drugbank.com/bio_entities/BE0009712TransporterHumansTranscription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription tr...
Polypeptides: POU domain, class 2, transcription factor 1Tyrosine-protein phosphatase non-receptor type 2
go.drugbank.com/bio_entities/BE0012706TargetHumansNegatively regulates cytokine (IL2/interleukin-2 and interferon)-mediated signaling through dephosphorylation of the cytoplasmic kinases JAK1, JAK3 and their substrate STAT1, that propagate signaling downstream
Polypeptides: Tyrosine-protein phosphatase non-receptor type 2Dual specificity tyrosine-phosphorylation-regulated kinase 2
go.drugbank.com/bio_entities/BE0017531TargetHumansSerine/threonine-protein kinase involved in the regulation of the mitotic cell cycle, cell proliferation, apoptosis, organization of the cytoskeleton and neurite outgrowth (PubMed:11311121, PubMed:12588975, PubMed:16511445, PubMed:166116...
Polypeptides: Dual specificity tyrosine-phosphorylation-regulated kinase 2Cyproterone acetate
go.drugbank.com/drugs/DB04839ApprovedInvestigationalIt is used in the treatment of hypersexuality in males, as a palliative in prostatic carcinoma, and, in combination with estrogen, for the therapy of severe acne and hirsutism in females.
Synonyms: Cyproterone 17-O-acetateMixtures: DONABELLA® 2 MG /0.035 MG, DONABELLA® 2 MG /0.035 MGHydralazine
go.drugbank.com/drugs/DB01275ApprovedInvestigationalOriginally developed in the 1950s as a malaria treatment, hydralazine showed antihypertensive ability and was soon repurposed. … [A186820,L8782,L8785] Hydralazine is no longer a first line therapy for these indications since the development of newer antihypertensive medications.
Synonyms: (1Z)-1(2H)-Phthalazinone hydrazone, Hydrazone 1(2H)-phthalazinoneInternational brands: Cesoline W, Cesoline Y2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
go.drugbank.com/bio_entities/BE0001450TargetEscherichia coli (strain K12)Catalyzes the transfer of pyrophosphate from adenosine triphosphate (ATP) to 6-hydroxymethyl-7,8-dihydropterin, an enzymatic step in folate biosynthesis pathway.
Polypeptides: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinaseFunction: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activityGamma-aminobutyric acid receptor subunit beta-2
go.drugbank.com/bio_entities/BE0002346TargetHumansGABAARs containing alpha-1 and beta-2 or -3 subunits exhibit synaptogenic activity; the gamma-2 subunit being necessary but not sufficient to induce rapid synaptic contacts formation (PubMed:23909897, … Extrasynaptic beta-2 receptors contribute to the tonic GABAergic inhibition (By similarity).
Polypeptides: Gamma-aminobutyric acid receptor subunit beta-2Synonyms: GABAAR subunit beta-2, GABA(A) receptor subunit beta-2Gamma-aminobutyric acid receptor subunit gamma-2
go.drugbank.com/bio_entities/BE0003592TargetHumansGABAARs containing alpha-1 and beta-2 or -3 subunits exhibit synaptogenic activity; the gamma-2 subunit being necessary but not sufficient to induce rapid synaptic contacts formation (PubMed:23909897, … Gamma-2/GABRG2-containing GABAARs are found at both synaptic and extrasynaptic sites (By similarity).
Polypeptides: Gamma-aminobutyric acid receptor subunit gamma-2Synonyms: GABAAR subunit gamma-2, GABA(A) receptor subunit gamma-2