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Displaying results 5321 - 5330 of 10000 in total
  1. Drug

    Finerenone

    go.drugbank.com/drugs/DB16165
    ApprovedInvestigational

    [A236544,L34739] Finerenone was granted FDA approval on 9 July 2021,[L34739] followed by the EMA approval on 11 March 2022.[L41449] … Finerenone, or BAY 94-8862, is a mineralocorticoid receptor antagonist indicated to reduce the risk of sustained decline in glomerular filtration rate, end stage kidney disease, cardiovascular death, heart

    Categories: Heterocyclic Compounds, 2-Ring, Cytochrome P-450 SubstratesProducts: KERENDİA 20 MG FİLM KAPLI TABLET, 28 ADET, KERENDİA 20 MG FİLM KAPLI TABLET, 98 ADET
  2. Target

    2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial

    go.drugbank.com/bio_entities/BE0000518
    TargetHumans

    Pyridoxal phosphate (PLP) dependent enzyme, which catalyzes the cleavage of 2-amino-3-oxobutanoate to glycine and acetyl-CoA

    Polypeptides: 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial
  3. Target

    NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2

    go.drugbank.com/bio_entities/BE0000550
    TargetHumans

    Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The ...

    Polypeptides: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2
  4. Target

    3-oxo-5-alpha-steroid 4-dehydrogenase 2

    go.drugbank.com/bio_entities/BE0000585
    TargetEnzymeHumans

    Catalyzes the irreversible stereospecific reduction of the delta 4,5 bond (double bond between carbons 4 and 5) of various 3-oxo steroids (3-keto steroids) producing their 5alpha dihydro-3-oxo forms (PubMed:10898110, PubMed:23685396). Co...

    Polypeptides: 3-oxo-5-alpha-steroid 4-dehydrogenase 2Synonyms: S5AR 2, SR type 2
  5. Target

    NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial

    go.drugbank.com/bio_entities/BE0000729
    TargetEnzymeHumans

    Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed:22036843, PubMed:2803...

    Polypeptides: NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial
  6. Target

    Large neutral amino acids transporter small subunit 2

    go.drugbank.com/bio_entities/BE0000789
    TargetTransporterHumans

    Associates with SLC3A2 to form a functional heterodimeric complex that translocates small and large neutral amino acids with broad specificity and a stoichiometry of 1:1. Functions as amino acid antiporter mediating the influx of extrace...

    Polypeptides: Large neutral amino acids transporter small subunit 2Synonyms: L-type amino acid transporter 2
  7. Target

    Nuclear receptor subfamily 1 group I member 2

    go.drugbank.com/bio_entities/BE0000956
    TargetHumans

    Nuclear receptor that acts as a transcription factor regulating genes involved in the metabolism and excretion of xenobiotics, drugs, and endogenous compounds. Activated by a broad range of endogenous steroids (e.g. pregnenolone, progest...

    Polypeptides: Nuclear receptor subfamily 1 group I member 2
  8. Target

    6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1

    go.drugbank.com/bio_entities/BE0001073
    TargetEnzymeHumans

    Synthesis and degradation of fructose 2,6-bisphosphate

    Polypeptides: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1Synonyms: 6PF-2-K/Fru-2,6-P2ase 1, 6PF-2-K/Fru-2,6-P2ase liver isozyme
  9. Target

    4-diphosphocytidyl-2-C-methyl-D-erythritol kinase

    go.drugbank.com/bio_entities/BE0001574
    TargetShigella flexneri

    Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.

    Polypeptides: 4-diphosphocytidyl-2-C-methyl-D-erythritol kinaseSynonyms: 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase
  10. Target

    Putative 4-hydroxy-4-methyl-2-oxoglutarate aldolase

    go.drugbank.com/bio_entities/BE0001689
    TargetMycobacterium tuberculosis

    Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate.

    Polypeptides: Putative 4-hydroxy-4-methyl-2-oxoglutarate aldolaseFunction: 4-hydroxy-4-methyl-2-oxoglutarate aldolase activity