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Levosimendan
go.drugbank.com/drugs/DB00922ApprovedInvestigationalWithdrawnLevosimendan increases calcium sensitivity to myocytes by binding to troponin C in a calcium dependent manner. This increases contractility without raising calcium levels. … Levosimendan is under investigation in clinical trial NCT00527059 (Renal Effects of Levosimendan in Patients Admitted With Acute Decompensated Heart Failure).
Categories: Compounds used in a research, industrial, or household setting, Heterocyclic Compounds, 1-RingProducts: SIMDAX 2.5 MG/ML KONSANTRE INF.COZ.5 ML X FLAKON, 1 ADET, DAXIM® 2.5 MG / MLOrlistat
go.drugbank.com/drugs/DB01083ApprovedInvestigationalIt was approved by the FDA for use in combination with a reduced-calorie diet in 1999. … [A229928] Orlistat is a lipase inhibitor used in the treatment of obesity that works by inhibiting fat-metabolizing enzymes.
Categories: Cytochrome P-450 CYP3A Inducers, Cytochrome P-450 CYP3A4 InducersProducts: TRIMFAT® 60 MG CAPSULAS, ORLOFF 60 MG SERT KAPSÜL, 42 ADETSirolimus
go.drugbank.com/drugs/DB00877ApprovedInvestigational[L39267] Sirolimus was also investigated in other cancers such as skin cancer, Kaposi’s Sarcoma, cutaneous T-cell lymphomas, and tuberous sclerosis. … Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island
Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic IndexProducts: RAPAMUNE 1 MG/ML 60 ML ORAL SOLUSYON, RAPAMUNE TABLET 1 mgRifamycin
go.drugbank.com/drugs/DB11753ApprovedInvestigationalWithdrawnThe parent compound of rifamycin was rifamycin B which was originally obtained as a main product in the presence of diethylbarburitic acid. … Product which allowed it to have a status a priority review.
Mixtures: RIFETEM 250 MG / 3 ML AMPUL, 1 ADET, RİF 250 MG/3 ML IM ENJEKSİYONLUK ÇÖZELTİ (1 AMPUL)Categories: Heterocyclic Compounds with 4 or More Rings, MATE 1 InhibitorsDihydrocodeine
go.drugbank.com/drugs/DB01551ApprovedIllicitIt is semi-synthetic, and was developed in Germany in 1908 during an international search to find a more effective antitussive agent to help reduce the spread of airborne infectious diseases such as tuburculosis … It was marketed in 1911.
Mixtures: J-cof Dhc, J-max DhcCategories: Heterocyclic Compounds with 4 or More Rings, Cytochrome P-450 SubstratesIxekizumab
go.drugbank.com/drugs/DB11569ApprovedInvestigationalIxekizumab is a humanized immunoglobulin G subclass 4 (IgG4) monoclonal antibody (mAb) against interleukin-17A (IL-17A) and prevents it from interacting with the IL-17A receptor. … In particular, IL-17A has been found to be implicated in a variety of autoimmune diseases including Rheumatoid Arthritis and plaque psoriasis.
Categories: Skin and Mucous Membrane AgentsProducts: COPELLOR 80 MG/1 ML ENJEKSİYONLUK ÇÖZELTİ İÇEREN KULLANIMA HAZIR KALEM, 1 ADET, TALTZ SOLUTION FOR INJECTION IN PRE-FILLED PEN 80 mg/mlAscorbyl phosphate
go.drugbank.com/drugs/DB11352ApprovedInvestigationalC that is readily absorbed into the skin with a hydrating effect on the skin [A27212]. … While ascorbyl phosphate salts provide a constant delivery of vitamin C into the skin, they also mediate an antioxidant action to act as a free radical scavenger and increases collagen production *in vitro
Mixtures: Le-Blen Vitamin C SerumCategories: Vitamin C and analoguesMenadione
go.drugbank.com/drugs/DB00170ApprovedNutraceuticalA synthetic naphthoquinone without the isoprenoid side chain and biological activity, but can be converted to active vitamin K2, menaquinone, after alkylation in vivo.
Mixtures: LIBAVIT-K 20 MG AMPUL, 5 ADETCategories: Vitamin K, Cytochrome P-450 CYP1A2 Inducers