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Displaying results 541 - 550 of 3730 in total
  1. Target

    Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1

    go.drugbank.com/bio_entities/BE0018277
    TargetHumans

    Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors (PubMed:14966521, PubMed:

    Polypeptides: Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1Synonyms: Leucine-rich repeat neuronal protein 1, Leucine-rich repeat neuronal protein 6A
  2. Drug

    Doconexent

    go.drugbank.com/drugs/DB03756
    ApprovedInvestigational

    A mixture of fish oil and primrose oil, doconexent is used as a high-docosahexaenoic acid (DHA) supplement. DHA is a 22 carbon chain with 6 cis double bonds with anti-inflammatory effects. It can be biosythesized from alpha-linolenic aci...

    Mixtures: Se-Tan DHA, Se-Tan DHACategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C9 Inhibitors
  3. Target

    Dopamine receptor D1

    go.drugbank.com/bio_entities/BE0000020
    TargetHumans

    Also acts as a receptor for D-lysergic (LSD) psychedelic drug (PubMed:39094559) … Dopamine binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase

    Polypeptides: Dopamine receptor D1Synonyms: Dopamine D1 receptor, D(1A) dopamine receptor
  4. Target

    Growth hormone receptor

    go.drugbank.com/bio_entities/BE0000075
    TargetHumans

    Receptor for pituitary gland growth hormone (GH1) involved in regulating postnatal body growth (PubMed:1549776, PubMed:2825030, PubMed:8943276).

    Polypeptides: Growth hormone receptorSynonyms: GH receptor, Somatotropin receptor
  5. Target

    Dopamine receptor D5

    go.drugbank.com/bio_entities/BE0000145
    TargetHumans

    Dopamine binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase … G protein-coupled receptor for dopamine, a catecholamine neurotransmitter hormone that functions as the brain's 'reward chemical', driving motivation, reinforcement learning and pleasure (PubMed:11500503

    Polypeptides: Dopamine receptor D5Synonyms: D(1B) dopamine receptor, Dopamine D5 receptor
  6. Target

    Adenosine receptor A2b

    go.drugbank.com/bio_entities/BE0000241
    TargetHumans

    Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase

    Polypeptides: Adenosine receptor A2bFunction: G protein-coupled adenosine receptor activity
  7. Target

    Folate receptor beta

    go.drugbank.com/bio_entities/BE0000271
    TargetTransporterHumans

    Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release

    Polypeptides: Folate receptor betaSynonyms: Folate receptor 2, Folate receptor, fetal/placental
  8. Target

    Vasopressin V2 receptor

    go.drugbank.com/bio_entities/BE0000293
    TargetHumans

    G protein-coupled receptor for arginine vasopressin, an antidiuretic that promotes renal water reabsorption (PubMed:1534149, PubMed:19440390, PubMed:33664408, PubMed:33742150). … Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (cAMP

    Polypeptides: Vasopressin V2 receptorSynonyms: Antidiuretic hormone receptor, Renal-type arginine vasopressin receptor
  9. Target

    Dopamine receptor D3

    go.drugbank.com/bio_entities/BE0000581
    TargetHumans

    Dopamine binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase … G protein-coupled receptor for dopamine, a catecholamine neurotransmitter hormone that functions as the brain's 'reward chemical', driving motivation, reinforcement learning and pleasure (PubMed:19520868

    Polypeptides: Dopamine receptor D3Synonyms: Dopamine D3 receptor
  10. Target

    Glutamate receptor 1

    go.drugbank.com/bio_entities/BE0000640
    TargetHumans

    The receptor then desensitizes rapidly and enters in a transient inactive state, characterized by the presence of bound agonist (By similarity). … Ionotropic glutamate receptor that functions as a ligand-gated cation channel, gated by L-glutamate and glutamatergic agonists such as alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), quisqualic

    Polypeptides: Glutamate receptor 1Synonyms: AMPA-selective glutamate receptor 1, Glutamate receptor ionotropic, AMPA 1