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Displaying results 561 - 570 of 10000 in total
  1. Pathway

    Intracellular Signalling Through Histamine H2 Receptor and Histamine

    smpdb.ca/view/SMP0000335
    Signaling

    Histamine is an organic nitrogenous compound that is involved in local immune responses and it is a neurotransmitter for brain. … Histamine can mediate various actions by interacting with histamine receptors (H1, H2, H3 and H4).

    Drugs: ATP · Magnesium cation · Cyclic adenosine monophosphate · Pyrophosphoric acid
  2. Pathway

    Metabolism and Physiological Effects of Indoxyl glucoside (indican)

    smpdb.ca/view/SMP0124742
    Metabolic

    It is also shown to cause vascular calcification and disrupt the electron transport chain and oxidative phosphorylation causing muscle atrophy. … Indoxyl glucoside (indican) is an indole compound that is formed through gut microbial metabolism from dietary tryptophan and a sulfation reaction in liver hepatic cells.

    Drugs: Tryptophan · Mesoheme · Indole · Indoxyl sulfate
  3. Pathway

    Metabolism and Phsyiological Effects of Asymmetric dimethylarginine (ADMA)

    smpdb.ca/view/SMP0124747
    Metabolic

    L-arginine is obtained from protein-rich foods like red meat, poultry, dairy and eggs. It is absorbed in the intestine to the blood. … This elevates blood pressure, causes vasoconstriction, impairs endothelium-dependent relaxation, and increases endothelial cell adhesiveness.

    Drugs: Ademetionine · Arginine
  4. Pathway

    Metabolism and Physiological Effects of Symmetric dimethylarginine (SDMA)

    smpdb.ca/view/SMP0124764
    Metabolic

    L-arginine is obtained from protein-rich foods like red meat, poultry, dairy and eggs. It is absorbed in the intestine to the blood. … It enters cells in the body and is metabolized to SDMA via the enzyme protein arginine methyltransferase-5 or protein arginine methyltransferase-7.

    Drugs: Ademetionine · Arginine · Symmetric dimethylarginine
  5. Pathway

    Metabolism and Physiological Effects of β-Hydroxybutyric acid

    smpdb.ca/view/SMP0126987
    Metabolic

    electron transport chain and other redox reactions. β-Hydroxybutyrate is the most abundant of the ketone bodies, followed by acetoacetate and finally acetone … Ketone synthesis in the liver produces acetoacetate and beta-hydroxybutyrate from two acetyl CoA molecules. Acetyl-CoA is a metabolite derived from glucose, fatty acid, and amino acid catabolism.

    Drugs: NADH · Acetoacetic acid
  6. Drug

    Perphenazine

    go.drugbank.com/drugs/DB00850
    ApprovedInvestigational

    An antipsychotic phenothiazine derivative with actions and uses similar to those of chlorpromazine.

    Mixtures: Perphenazine and Amitriptyline Hydrochloride, Perphenazine and Amitriptyline HydrochlorideProducts: Trilafon Conc 16mg/5ml, PMS Perphenazine Tab 16mg
  7. Pathway

    Intracellular Signalling Through Adenosine Receptor A2b and Adenosine

    smpdb.ca/view/SMP0000321
    Signaling

    Adenosine is thought to play a role in the pathophysiology of asthma. Stimulation of A2B can induce production of interleukin-8 mast cells. The adenosine receptor A2b activates G(s) proteins which lead to the activation of adenylyl cycla...

    Drugs: ATP · Adenosine · Magnesium cation · Zinc · Cyclic adenosine monophosphate · Pyrophosphoric acid
  8. Pathway

    Metabolism and Physiological Effects of 2-Aminobenzoic acid

    smpdb.ca/view/SMP0126869
    Disease

    Outside of the human body, 2-Aminobenzoic acid has been detected, but not quantified in several different foods, such as mamey sapotes, prairie turnips, rowals, natal plums, and hyacinth beans. … Uremic syndrome may affect any part of the body and can cause nausea, vomiting, loss of appetite, and weight loss.

    Drugs: Tryptophan · Alanine · Formic acid · Kynurenine · Mesoheme · Anthranilic acid +1 more
    Enzymes: Neutral and basic amino acid transport protein rBAT
  9. Pathway

    Metabolism and Physiological Effects of 4-Hydroxyphenylacetic acid

    smpdb.ca/view/SMP0126879
    Metabolic

    It is also a parent compound for other transformation products, including but not limited to, methyl 2-(4-hydroxyphenyl)acetate, ixerochinolide, and lactucopicrin 15-oxalate. … , and C. propionicum. l-tyrosine, derived from diet and endogenous proteins and peptides, can be converted to phenol and 4-hydroxyphenylpyruvate.

    Drugs: Pyridoxal phosphate · Tyrosine · Glutamic acid · P-Cresol · Oxogluric acid · 4-Hydroxyphenylpyruvic acid
  10. Drug

    Tramadol

    go.drugbank.com/drugs/DB00193
    ApprovedInvestigational

    Tramadol differs from other traditional opioid medications in that it doesn't just act as a μ-opioid agonist, but also affects monoamines by modulating the effects of neurotransmitters involved in the … These pathways are complementary and synergistic, improving tramadol's ability to modulate the perception of and response to pain.

    Mixtures: DICLOFENACO SODICO /TRAMADOL HCL 25 MG/25MG., Trabest 37.5mg/325mg TabletsCategories: tramadol and celecoxib, tramadol and paracetamol