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Displaying results 581 - 590 of 10000 in total
  1. Pathway

    Metabolism and Physiological Effects of Symmetric dimethylarginine (SDMA)

    smpdb.ca/view/SMP0124764
    Metabolic

    Symmetrical dimethylarginine (SDMA) is produced from L-arginine. L-arginine is obtained from protein-rich foods like red meat, poultry, dairy and eggs. It is absorbed in the intestine to the blood. … It enters cells in the body and is metabolized to SDMA via the enzyme protein arginine methyltransferase-5 or protein arginine methyltransferase-7.

    Drugs: Ademetionine · Arginine · Symmetric dimethylarginine
  2. Pathway

    Metabolism and Physiological Effects of β-Hydroxybutyric acid

    smpdb.ca/view/SMP0126987
    Metabolic

    Ketone synthesis in the liver produces acetoacetate and beta-hydroxybutyrate from two acetyl CoA molecules. Acetyl-CoA is a metabolite derived from glucose, fatty acid, and amino acid catabolism. … and renal gluconeogenesis.

    Drugs: NADH · Acetoacetic acid
  3. Pathway

    Intracellular Signalling Through Adenosine Receptor A2b and Adenosine

    smpdb.ca/view/SMP0000321
    Signaling

    Adenosine is thought to play a role in the pathophysiology of asthma. Stimulation of A2B can induce production of interleukin-8 mast cells. The adenosine receptor A2b activates G(s) proteins which lead to the activation of adenylyl cycla...

    Drugs: ATP · Adenosine · Magnesium cation · Zinc · Cyclic adenosine monophosphate · Pyrophosphoric acid
  4. Pathway

    Metabolism and Physiological Effects of 2-Aminobenzoic acid

    smpdb.ca/view/SMP0126869
    Disease

    In addition, 2-aminobenzoic acid and L-alanine can be biosynthesized from L-kynurenine through its interaction with the enzyme kynureninase. … In particular, 2-aminobenzoic acid and formic acid can be biosynthesized from formylanthranilic acid through its interaction with the enzyme kynurenine formamidase.

    Drugs: Tryptophan · Alanine · Formic acid · Kynurenine · Mesoheme · Anthranilic acid +1 more
    Enzymes: Neutral and basic amino acid transport protein rBAT
  5. Pathway

    Metabolism and Physiological Effects of 4-Hydroxyphenylacetic acid

    smpdb.ca/view/SMP0126879
    Metabolic

    , and C. propionicum. l-tyrosine, derived from diet and endogenous proteins and peptides, can be converted to phenol and 4-hydroxyphenylpyruvate. … To a small extent, 4-hydroxyphenylpyruvate and ammonia can also be formed by the enzyme phenylalanine dehydrogenase (EC 1.4.1.20.) from l-tyrosine.

    Drugs: Pyridoxal phosphate · Tyrosine · Glutamic acid · P-Cresol · Oxogluric acid · 4-Hydroxyphenylpyruvic acid
  6. Drug

    Risperidone

    go.drugbank.com/drugs/DB00734
    ApprovedInvestigational

    [L12885] Schizophrenia and various mood disorders are thought to be caused by an excess of dopaminergic D2 and serotonergic 5-HT2A activity, resulting in overactivity of central mesolimbic pathways … and mesocortical pathways, respectively.

    Products: RISPERDAL CONSTA 25MG, RISPERDAL 2MG
  7. Drug

    Agomelatine

    go.drugbank.com/drugs/DB06594
    ApprovedInvestigational

    Agomelatine was developed in Europe by Servier Laboratories Ltd. and submitted to the European Medicines Agency (EMA) in 2005. … Agomelatine is a potent agonist at melatonin receptors and an antagonist at serotonin-2C (5-HT2C) receptors, tested in an animal model of depression.

    Products: AGOMAVAL 25MG FTA, VALDOXAN 25MG
  8. Drug

    Alfuzosin

    go.drugbank.com/drugs/DB00346
    Approved

    [L31593] It was initially approved by the FDA in 2003 and is marketed by several pharmaceutical companies.[L9251] … [A228483] Alfuzosin is an alpha-1 adrenergic blocker used in the symptomatic treatment of BPH that works by relaxing the muscles in the prostate and bladder neck.

    Categories: alfuzosin and finasteride, Genito Urinary System and Sex HormonesProducts: ALFUZOSIN WINTHROP 2.5MG, UROXATRAL 10MG
  9. Drug

    Methimazole

    go.drugbank.com/drugs/DB00763
    ApprovedInvestigational

    pro-drug [carbimazole], which is an antithyroid medication used in the United Kingdom and parts of the former British Commonwealth. … [A184559,A184733,A184694] It was first introduced as an antithyroid agent in 1949[A184502] and is now commonly used in the management of hyperthyroidism, particularly in those for whom more aggressive

    Categories: Sex Hormones and Insulins, Hormones, Hormone Substitutes, and Hormone AntagonistsProducts: THIAMAZOL 10MG HEXAL, THIAMAZOL ARISTO 10MG
  10. Drug

    Capsicum oleoresin

    go.drugbank.com/drugs/DB11131
    Approved

    Capsicum oleoresin is an oily organic resin derived from the fruit of plants in the Capsicum genus, such as chilli peppers. … Due to its analgesic properties, capsicum oleoresin is used to temporarily relieve of minor aches and pains of muscles and joints as an active ingredient in topical OTC preparations and has been studied

    Mixtures: Half and Half Balm, Hot Spice and IceProducts: Sheffield Arthritis and Muscle Pain Relief, Diabet Aid