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Displaying results 581 - 590 of 10000 in total
  1. Drug

    Methionine

    go.drugbank.com/drugs/DB00134
    ApprovedInvestigationalNutraceutical

    A sulfur containing essential amino acid that is important in many body functions. It is a chelating agent for heavy metals.

    Mixtures: AMINOSTERIL N-HEPA 8%, Aminoven Infant 10% w/vSynonyms: (S)-2-amino-4-(methylthio)butanoic acid, L-a-Amino-g-methylthiobutyric acid
  2. Drug

    Butabarbital

    go.drugbank.com/drugs/DB00237
    ApprovedIllicitWithdrawn

    [A201977,L13613] Butabarbital is less commonly used in recent years, as more patients are typically prescribed benzodiazepines. … [A19735] Its short duration of action gives butabarbital a high abuse potential, comparable to [secobarbital].[A201977,A201980] Butabarbital was granted FDA approval on 5 June 1939.[L13613]

    Categories: Heterocyclic Compounds, 1-RingSynonyms: 5-ethyl-5-(1-methylpropyl)barbituric acid, 5-ethyl-5-(1-methylpropyl)-2,4,6(1H,3H,5H)-pyrimidinetrione
  3. Drug

    Tovorafenib

    go.drugbank.com/drugs/DB15266
    ApprovedInvestigational

    Tovorafenib is a selective type II RAF kinase inhibitor with anti-tumour activity. … [A263597] It was granted accelerated approval by the FDA, making it the first FDA approval of a systemic therapy for the treatment of pediatric low-grade glioma, with BRAF rearrangements.

    Categories: Cytochrome P-450 CYP1A2 Inducers, Cytochrome P-450 CYP2B6 InducersSynonyms: 4-Pyrimidinecarboxamide, 6-amino-5-chloro-N-[(1R)-1-[5-[[[5-chloro-4-(trifluoromethyl)-2-pyridinyl]amino]carbonyl]-2-thiazolyl]ethyl]-, 6-Amino-5-chloro-N-((1R)-1-(5-(((5-chloro-4-(trifluoromethyl)-2-pyridinyl)amino)carbonyl)-2-thiazolyl)ethyl)-4-pyrimidinecarboxamide
  4. Target

    Glycine receptor subunit beta

    go.drugbank.com/bio_entities/BE0000055
    TargetHumans

    Subunit of heteromeric glycine-gated chloride channels (PubMed:11929858, PubMed:15302677, PubMed:16144831, PubMed:22715885, PubMed:23238346, PubMed:25445488, PubMed:34473954, PubMed:8717357). Plays an important role in the down-regulatio...

    Polypeptides: Glycine receptor subunit betaSynonyms: Glycine receptor 58 kDa subunit
  5. Target

    Beta-1 adrenergic receptor

    go.drugbank.com/bio_entities/BE0000172
    TargetHumans

    G protein-coupled receptor for catecholamines that couples to G(s) proteins to activate adenylate cyclase and cAMP-dependent pathway (PubMed:10212248, PubMed:12391161, PubMed:15358775).

    Polypeptides: Beta-1 adrenergic receptorFunction: alpha-2A adrenergic receptor binding
  6. Target

    5-hydroxytryptamine receptor 1A

    go.drugbank.com/bio_entities/BE0000291
    TargetHumans

    G protein-coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:22957663, PubMed:3138543, PubMed:33762731, PubMed:37935376, PubMed:37935377, PubMed:8138923, PubMed:8393041). … Also functions as a receptor for various drugs and psychoactive substances (PubMed:22957663, PubMed:3138543, PubMed:33762731, PubMed:38552625, PubMed:8138923, PubMed:8393041).

    Polypeptides: 5-hydroxytryptamine receptor 1ASynonyms: Serotonin receptor 1A
  7. Target

    5-hydroxytryptamine receptor 3A

    go.drugbank.com/bio_entities/BE0000311
    TargetHumans

    Forms serotonin (5-hydroxytryptamine/5-HT3)-activated cation-selective channel complexes, which when activated cause fast, depolarizing responses in neurons

    Polypeptides: 5-hydroxytryptamine receptor 3ASynonyms: Serotonin receptor 3A, 5-hydroxytryptamine receptor 3
  8. Target

    Thyroid hormone receptor beta

    go.drugbank.com/bio_entities/BE0000315
    TargetHumans

    Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine

    Polypeptides: Thyroid hormone receptor betaSynonyms: Nuclear receptor subfamily 1 group A member 2
  9. Target

    Follicle-stimulating hormone receptor

    go.drugbank.com/bio_entities/BE0000387
    TargetHumans

    G protein-coupled receptor for follitropin, the follicle-stimulating hormone (PubMed:11847099, PubMed:24058690, PubMed:24692546). … Also affects hepatic cholesterol metabolism by increasing serum total and low-density-lipoprotein cholesterol (LDL-C) by inhibiting the expression of LDL receptor (LDLR) (PubMed:26583582)

    Polypeptides: Follicle-stimulating hormone receptorSynonyms: Follitropin receptor
  10. Target

    Muscarinic acetylcholine receptor M4

    go.drugbank.com/bio_entities/BE0000405
    TargetHumans

    The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action

    Polypeptides: Muscarinic acetylcholine receptor M4Function: G protein-coupled acetylcholine receptor activity