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Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1
go.drugbank.com/bio_entities/BE0002559TargetHumansPlays a role in determining the extent and pattern of sulfation of heparan sulfate. … Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate (PubMed:35137078, PubMed:9230113, PubMed:9744796
Polypeptides: Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1Synonyms: N-heparan sulfate sulfotransferase 1, [Heparan sulfate]-glucosamine N-sulfotransferase 1NACHT, LRR and PYD domains-containing protein 3
go.drugbank.com/bio_entities/BE0010347TargetHumans, such as asbestos, silica, aluminum salts, cytosolic dsRNA, etc (PubMed:16407889, PubMed:18403674, PubMed:18604214, PubMed:19414800, PubMed:23871209). … Recruitment of pro-caspase-1 (proCASP1) to the NLRP3 inflammasome promotes caspase-1 (CASP1) activation, which subsequently cleaves and activates inflammatory cytokines IL1B and IL18 and gasdermin-D (GSDMD
Polypeptides: NACHT, LRR and PYD domains-containing protein 3Zinc finger and BTB domain-containing protein 7A
go.drugbank.com/bio_entities/BE0012406TargetHumansDirectly and specifically binds to the consensus sequence 5'-[GA][CA]GACCCCCCCCC-3' and represses transcription both by regulating the organization of chromatin and through the direct recruitment of transcription … That is, recruits the chromatin regulator HDAC1 to the SMAD4-DNA complex and in parallel prevents the recruitment of the transcriptional activators CREBBP and EP300 (PubMed:25514493).
Polypeptides: Zinc finger and BTB domain-containing protein 7ASynonyms: POZ and Krueppel erythroid myeloid ontogenic factorA disintegrin and metalloproteinase with thrombospondin motifs 4
go.drugbank.com/bio_entities/BE0004687EnzymeTargetHumansCleaves aggrecan, a cartilage proteoglycan, at the '392-Glu-|-Ala-393' site and may be involved in its turnover (PubMed:10356395, PubMed:10827174). Also cleaves COMP (PubMed:39672391). … May play an important role in the destruction of aggrecan in arthritic diseases. Could be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease
Polypeptides: A disintegrin and metalloproteinase with thrombospondin motifs 4A disintegrin and metalloproteinase with thrombospondin motifs 13
go.drugbank.com/bio_entities/BE0009336EnzymeTargetHumansCleaves the vWF multimers in plasma into smaller forms thereby controlling vWF-mediated platelet thrombus formation
Polypeptides: A disintegrin and metalloproteinase with thrombospondin motifs 13T-cell immunoreceptor with Ig and ITIM domains
go.drugbank.com/bio_entities/BE0010742TargetHumansIn turn, inhibits PI3K and MAPK signaling cascades (PubMed:23154388). … In addition, associates with beta-arrestin-2/ARRB2 to recruit SHIP1/INPP5D that suppresses autoubiquitination of TRAF6 and subsequently inhibits NF-kappa-B signaling pathway (PubMed:24817116).
Polypeptides: T-cell immunoreceptor with Ig and ITIM domainsSynonyms: V-set and immunoglobulin domain-containing protein 9, V-set and transmembrane domain-containing protein 3Lysosomal acid glucosylceramidase
go.drugbank.com/bio_entities/BE0000978TargetEnzymeHumansPlays a central role in the degradation of complex lipids and the turnover of cellular membranes (PubMed:27378698). … Can also hydrolyze cholesteryl 3-beta-D-glucoside producing glucose and cholesterol (PubMed:24211208, PubMed:26724485, PubMed:39395789).
Polypeptides: Lysosomal acid glucosylceramidaseSynonyms: Acid beta-glucosidase, Lysosomal acid GCaseTesticular acid phosphatase
go.drugbank.com/bio_entities/BE0019349TargetHumansRegulates odontoblast cell fate via its extracellular catalytic domain by inhibiting proliferation and promoting differentiation (By similarity)
Polypeptides: Testicular acid phosphataseSynonyms: Acid phosphatase 4Heparan sulfate glucosamine 3-O-sulfotransferase 3A1
go.drugbank.com/bio_entities/BE0001541TargetHumansSulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate … The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes simplex virus-1 (HSV-1) and permits its entry (PubMed:10520990).
Polypeptides: Heparan sulfate glucosamine 3-O-sulfotransferase 3A1Synonyms: Heparan sulfate 3-O-sulfotransferase 3A1, Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3A1Heparan sulfate glucosamine 3-O-sulfotransferase 1
go.drugbank.com/bio_entities/BE0004436TargetHumansCatalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact) (PubMed:8900198, PubMed:9988768). … Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan (PubMed:8900198, PubMed:9346953, PubMed:9988768
Polypeptides: Heparan sulfate glucosamine 3-O-sulfotransferase 1Synonyms: Heparan sulfate 3-O-sulfotransferase 1, Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 1