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Calcium-activated potassium channel subunit alpha-1
go.drugbank.com/bio_entities/BE0000553TargetHumansPossibly induces sleep when activated by melatonin and through melatonin receptor MTNR1A-dependent dissociation of G-beta and G-gamma subunits, leading to increased sensitivity to Ca(2+) and reduced synaptic … In cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map.
Polypeptides: Calcium-activated potassium channel subunit alpha-1Synonyms: Calcium-activated potassium channel, subfamily M subunit alpha-1Voltage-dependent calcium channel gamma-1 subunit
go.drugbank.com/bio_entities/BE0000679TargetHumansRegulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics
Polypeptides: Voltage-dependent calcium channel gamma-1 subunitSynonyms: Dihydropyridine-sensitive L-type, skeletal muscle calcium channel subunit gammaCalcium/calmodulin-dependent protein kinase type 1D
go.drugbank.com/bio_entities/BE0004324TargetHumansCalcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, activates CREB-dependent gene transcription, regulates calcium-mediated … granulocyte function and respiratory burst and promotes basal dendritic growth of hippocampal neurons.
Polypeptides: Calcium/calmodulin-dependent protein kinase type 1DCalcium-activated potassium channel subunit alpha-1
go.drugbank.com/bio_entities/BE0004784TargetMouseIn cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. … Highly sensitive to both iberiotoxin (IbTx) and charybdotoxin (CTX).
Polypeptides: Calcium-activated potassium channel subunit alpha-1Synonyms: Calcium-activated potassium channel, subfamily M subunit alpha-1Calcium/calmodulin-dependent protein kinase type 1
go.drugbank.com/bio_entities/BE0009417TargetHumansCalcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, regulates transcription activators activity, cell cycle, hormone … and activation of RAC1.
Polypeptides: Calcium/calmodulin-dependent protein kinase type 1Calcium/calmodulin-dependent protein kinase kinase 1
go.drugbank.com/bio_entities/BE0009418TargetHumansCalcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4.
Polypeptides: Calcium/calmodulin-dependent protein kinase kinase 1Synonyms: Calcium/calmodulin-dependent protein kinase kinase alphaIntermediate conductance calcium-activated potassium channel protein 4
go.drugbank.com/bio_entities/BE0000415TargetHumansFollowing calcium influx, the consecutive activation of KCNN4 channel leads to a hyperpolarization of the cell membrane potential and hence an increase of the electrical driving force for further calcium … Required for maximal calcium influx and proliferation during the reactivation of naive T-cells (PubMed:17157250, PubMed:18796614).
Polypeptides: Intermediate conductance calcium-activated potassium channel protein 4Function: calcium-activated potassium channel activitySmall conductance calcium-activated potassium channel protein 3
go.drugbank.com/bio_entities/BE0004427TargetHumansThe current is characterized by a voltage-independent activation, an intracellular calcium concentration increase-dependent activation and a single-channel conductance of 10 picosiemens (PubMed:12808432 … which binds the intracellular calcium allowing its opening (PubMed:12808432, PubMed:20562108, PubMed:31155282, PubMed:36502918).
Polypeptides: Small conductance calcium-activated potassium channel protein 3Small conductance calcium-activated potassium channel protein 1
go.drugbank.com/bio_entities/BE0004425TargetHumansThe current is characterized by a voltage-independent activation, an intracellular calcium concentration increase-dependent activation and a single-channel conductance of about 3 picosiemens (PubMed:8781233 … which binds the intracellular calcium allowing its opening (PubMed:17142458, PubMed:8781233, PubMed:9287325).
Polypeptides: Small conductance calcium-activated potassium channel protein 1Function: calcium-activated potassium channel activitySmall conductance calcium-activated potassium channel protein 2
go.drugbank.com/bio_entities/BE0004426TargetHumansThe inward rectification could be due to a blockade of the outward current by intracellular divalent cations such as calcium and magnesium and could also be due to an intrinsic property of the channel … The current is characterized by a voltage-independent activation, an intracellular calcium concentration increase-dependent activation and a single-channel conductance of about 3 picosiemens (PubMed:10991935
Polypeptides: Small conductance calcium-activated potassium channel protein 2