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Displaying results 51 - 60 of 167 in total
  1. Target

    Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1

    go.drugbank.com/bio_entities/BE0018277
    TargetHumans

    Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination (PubMed:15895088). … Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development (By similarity)

    Polypeptides: Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1Synonyms: Leucine-rich repeat and immunoglobulin domain-containing protein 1
  2. Target

    Adiponectin receptor

    go.drugbank.com/bio_entities/BE0010287
    TargetHumans

    Required for normal glucose and fat homeostasis and for maintaining a normal body weight. … Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed:12802337, PubMed:25855295). Required for normal body fat and glucose homeostasis.

    Synonyms: Progestin and adipoQ receptor family member 1, Progestin and adipoQ receptor family member I
  3. Target

    Immunoglobulin J chain

    go.drugbank.com/bio_entities/BE0009083
    TargetHumans

    In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces dimers and/or larger polymers.

    Synonyms: Joining chain of multimeric IgA and IgM
  4. Target

    Prolyl 3-hydroxylase OGFOD1

    go.drugbank.com/bio_entities/BE0002210
    TargetHumans

    Prolyl 3-hydroxylase that catalyzes 3-hydroxylation of 'Pro-62' of small ribosomal subunit uS12 (RPS23), thereby regulating protein translation termination efficiency. Involved in stress granule formation

    Synonyms: Termination and polyadenylation 1 homolog, 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1
  5. Target

    Complement C5

    go.drugbank.com/bio_entities/BE0000855
    TargetHumans

    Precursor of the C5a anaphylatoxin and complement C5b components of the complement pathways, which consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that … Activated downstream of classical, alternative, lectin and GZMK complement pathways (PubMed:12878586, PubMed:18204047, PubMed:30643019, PubMed:39914456, PubMed:39814882, PubMed:6554279)

    Synonyms: C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4
  6. Target

    Complement C3

    go.drugbank.com/bio_entities/BE0003455
    TargetHumans

    Precursor of non-enzymatic components of the classical, alternative, lectin and GZMK complement pathways, which consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and

    Synonyms: C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1
  7. Target

    Pregnancy zone protein

    go.drugbank.com/bio_entities/BE0009089
    TargetHumans

    Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase

    Synonyms: C3 and PZP-like alpha-2-macroglobulin domain-containing protein 6
  8. Target

    Serine/threonine-protein kinase ATR

    go.drugbank.com/bio_entities/BE0010060
    TargetHumans

    Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RBBP8, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis (PubMed:11114888, PubMed … Involved in the inflammatory response to genome instability and double-stranded DNA breaks: acts by localizing to micronuclei arising from genome instability and catalyzing phosphorylation of LMNA at '

    Synonyms: Ataxia telangiectasia and Rad3-related protein
  9. Target

    Potassium channel subfamily T member 1

    go.drugbank.com/bio_entities/BE0015369
    TargetHumans

    Contributes to synaptic development and plasticity (By similarity) … Acts as an important mediator of neuronal membrane excitability (PubMed:37494189). Contributes to the delayed outward currents (By similarity).

    Synonyms: Sodium and chloride-activated ATP-sensitive potassium channel Slo2.2
  10. Target

    Spermidine/spermine N(1)-acetyltransferase

    go.drugbank.com/bio_entities/BE0001716
    TargetBacillus subtilis (strain 168)

    Catalyzes the transfer of an acetyl group from acetyl coenzyme A (AcCoA) to an acceptor substrate and releases both CoA and the acetylated product. … Could also be involved in the negative control of sporulation as well as production of degradative enzymes such as alpha-amylase, levansucrase and alkaline phosphatase.

    Synonyms: Protease synthase and sporulation negative regulatory protein PAI 1