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Metabolism and Physiological Effects of Indoxyl glucuronide
smpdb.ca/view/SMP0123239MetabolicIndoxyl glucuronide is an indole compound that is formed through gut microbial metabolism from dietary tryptophan and a glucuronidation reaction in liver hepatic cells. … After being transported into gut microbes, tryptophan undergoes a reaction with the enzyme tryptophanase to form indole.
Metabolsim and Physiological Effects of 4-Ethylphenylsulfate
smpdb.ca/view/SMP0125541Metabolicacid. … It has also been found to be related to cardiovascular mortality and to cause cell apoptosis.
Drugs: Pyridoxal phosphate · Phenylalanine · Tyrosine · Iron · Oxogluric acid · Propanoic acid +3 moreEnzymes: Aromatic-amino-acid aminotransferaseMetabolism and Physiological Effects of N-Acetylphenylalanine
smpdb.ca/view/SMP0126720MetabolicTechnically, N-Acetyl-L-phenylalanine is a biologically available N-terminal capped form of the proteinogenic alpha amino acid L-phenylalanine. … N-Acetyl-L-phenylalanine can also be classified as an alpha amino acid or a derivatized alpha amino acid.
Drugs: PhenylalanineMetabolism and Physiological Effects of Phenol sulphate
smpdb.ca/view/SMP0126844MetabolicIn experimental models of diabetes, phenol sulphate administration has been shown to induce albuminuria and podocyte damage. … Phenol sulphate can be found in most mammals (mice, rats, sheep, dogs, humans) and likely most animals. Phenol sulphate is a uremic toxin.
Metabolism and Physiological Effects of Androsterone sulfate
smpdb.ca/view/SMP0127012MetabolicSubsequently, 3α-androstanediol and 3α-etiocholanediol are converted by 17β-HSD into androsterone and etiocholanolone, which is followed by their conjugation and excretion. … Then, 5α-DHT and 5β-DHT are converted by 3α-HSD into 3α-androstanediol and 3α-etiocholanediol, respectively.
Drugs: TestosteroneIntracellular Signalling Through Prostacyclin Receptor and Prostacyclin
smpdb.ca/view/SMP0000354SignalingProstacyclin binding to its receptor increases vasodilation and decreases platelet aggregation. … The receptor is a G-protein coupled receptor, upon its binding it activates G proteins causing the activation of adenylyl cyclase and production of cAMP messenger molecules. cAMP activates PKA (protein
Metabolism and Physiological Effects of Phenyl sulfate
smpdb.ca/view/SMP0123213MetabolicPhenyl sulphate is shown to cause albuminuria and diabetic kidney disease. … Phenyl sulphate is a phenolic compound that is formed through gut microbial metabolism from dietary tyrosine and a sulfation reaction in liver hepatic cells.
Metabolism and Physiological Effects of Para-cresol
smpdb.ca/view/SMP0123214MetabolicAfter being transported into gut microbes, tyrosine undergoes reactions with the enzymes tyrosine transaminase, 4-hydroxyphenylpyruvate oxidase and 4-hydroxylphenylacetate decarboxylase to form para-cresol … Para-cresol(P-cresol) is a phenolic compound that is formed through gut microbial metabolism from the amino acid tyrosine which is acquired from foods that are high in protein.
Metabolism and Physiological Effects of Indoxyl Sulfate
smpdb.ca/view/SMP0123237MetabolicIt is also shown to cause vascular calcification and disrupt the electron transport chain and oxidative phosphorylation causing muscle atrophy … Indoxyl sulfate is an indole compound that is formed through gut microbial metabolism from dietary tryptophan and a sulfation reaction in liver hepatic cells.
Metabolism and Physiological Effects of N-Acetylserine
smpdb.ca/view/SMP0126556MetabolicTechnically, N-Acetylserine is a biologically available N-terminal capped form of the proteinogenic alpha amino acid L-serine. … N-Acetylserine can also be classified as an alpha amino acid or a derivatized alpha amino acid.