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General transcription and DNA repair factor IIH helicase/translocase subunit XPB
go.drugbank.com/bio_entities/BE0012820TargetHumansIn transcription pre-initiation complexes induces and propagates a DNA twist to open DNA (PubMed:27193682, PubMed:33902107). … In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment.
Polypeptides: General transcription and DNA repair factor IIH helicase/translocase subunit XPBPhosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
go.drugbank.com/bio_entities/BE0005530TargetHumansDLC1 and results in translocation of the PTEN-DLC1 complex to the posterior of migrating cells to promote RHOA activation (PubMed:26166433). … Meanwhile, TNS3 switches binding preference from DLC1 to p85 and the TNS3-p85 complex translocates to the leading edge of migrating cells to activate RAC1 activation (PubMed:26166433).
Polypeptides: Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTENSynonyms: Phosphatase and tensin homologHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A
go.drugbank.com/bio_entities/BE0003717TargetHumansBinding to RAF1 reduces RAF1 'Ser-259' inhibitory-phosphorylation and stimulates RAF1-dependent EGF-activated ERK-signaling (PubMed:23509299). … Protects against cell death induced by hydrogen peroxide and staurosporine (PubMed:23509299)
Polypeptides: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8ALeucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1
go.drugbank.com/bio_entities/BE0018277TargetHumansIs also an important negative regulator of oligodentrocyte differentiation and axonal myelination (PubMed:15895088). … Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development (By similarity)
Polypeptides: Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1Synonyms: Leucine-rich repeat and immunoglobulin domain-containing protein 1Multiple coagulation factor deficiency protein 2
go.drugbank.com/bio_entities/BE0002120TargetHumansThe MCFD2-LMAN1 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins. Plays a role in the secretion of coagulation factors
Synonyms: Neural stem cell-derived neuronal survival proteinTrafficking protein particle complex subunit 4
go.drugbank.com/bio_entities/BE0004278TargetHumansPlays a role in vesicular transport from endoplasmic reticulum to Golgi and autophagy (PubMed:31794024). May play a role in dendrite postsynaptic membrane trafficking (By similarity)
Synonyms: Hematopoietic stem/progenitor cell protein 172Adiponectin receptor
go.drugbank.com/bio_entities/BE0010287TargetHumansADIPOQ-binding activates a signaling cascade that leads to increased PPARA activity, and ultimately to increased fatty acid oxidation and glucose uptake. … ADIPOQ-binding activates a signaling cascade that leads to increased AMPK activity, and ultimately to increased fatty acid oxidation, increased glucose uptake and decreased gluconeogenesis.
Synonyms: Progestin and adipoQ receptor family member 1, Progestin and adipoQ receptor family member IReceptor-type tyrosine-protein kinase FLT3
go.drugbank.com/bio_entities/BE0000147TargetHumansMutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways … Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR.
Synonyms: Stem cell tyrosine kinase 1Immunoglobulin J chain
go.drugbank.com/bio_entities/BE0009083TargetHumansIn the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces dimers and/or larger polymers. … It also helps to bind these immunoglobulins to secretory component
Synonyms: Joining chain of multimeric IgA and IgMProlyl 3-hydroxylase OGFOD1
go.drugbank.com/bio_entities/BE0002210TargetHumansProlyl 3-hydroxylase that catalyzes 3-hydroxylation of 'Pro-62' of small ribosomal subunit uS12 (RPS23), thereby regulating protein translation termination efficiency. Involved in stress granule formation
Synonyms: Termination and polyadenylation 1 homolog, 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1