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Agomelatine Serotonin Antagonist Action Pathway
smpdb.ca/view/SMP0126726Drug actionAgomelatine is structurally closely related to melatonin. Agomelatine is a potent agonist at melatonin receptors and an antagonist at serotonin-2C (5-HT2C) receptors and promotes dopamine and norepinephrine release. Agomelatine is indica...
Tropisetron Serotonin antagonist Action Pathway
smpdb.ca/view/SMP0126780Drug actionTropisetron is an indole derivative. Tropisetron competitively binds to and blocks the action of serotonin at 5HT3 receptors peripherally on vagus nerve terminals located in the gastrointestinal (GI) tract as well as centrally in the che...
Palonosetron Serotonin antagonist Action Pathway
smpdb.ca/view/SMP0126781Drug actionPalonosetron is a selective serotonin 5-HT3 receptor antagonist. The antiemetic activity of the drug is brought about through the inhibition of 5-HT3 receptors present both centrally (medullary chemoreceptor zone) and peripherally (GI tr...
Iloperidone Serotonin antagonist Action Pathway
smpdb.ca/view/SMP0126784Drug actionIloperidone shows high affinity and maximal receptor occupancy for dopamine D2 receptors in the caudate nucleus and putamen of the brains of schizophrenic patients. The improvement in cognition is attributed to iloperidone's high affinit...
Ethambutol Action Pathway
smpdb.ca/view/SMP0718083Drug actionEthambutol is a bacteriostatic antitubercular agent whose primary action targets the unique mycobacterial cell wall. After entering Mycobacterium tuberculosis cells, ethambutol specifically inhibits arabinosyltransferase enzymes (encoded...
Remoxipride Mechanism of Action Action Pathway
smpdb.ca/view/SMP0126480Drug actionRemoxipride is an atypical antipsychotic dopamine D2 antagonist. Chronic use upregulates the expression of D2 receptors, while downregulating the expression of D1 and D5 receptors in the prefrontal cortex. This activity may be related to...
Mesoridazine Dopamine Antagonist Action Pathway
smpdb.ca/view/SMP0126523Drug actionMesoridazine, the besylate salt of a metabolite of thioridazine, is a phenothiazine tranquilizer and a first generation typical antipsychotic. Based upon animal studies, mesoridazine, as with other phenothiazines, acts indirectly on reti...
Chlorprothixene Dopamine Antagonist Action Pathway
smpdb.ca/view/SMP0126577Drug actionChlorprothixene is a thioxanthene antipsychotic. Chlorprothixene blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; depresses the release of hypothalamic and hypophyseal hormones and is believed to depress the ...
Zuclopenthixol Dopamine Antagonist Action Pathway
smpdb.ca/view/SMP0126579Drug actionZuclopenthixol, also known as Zuclopentixol or Zuclopenthixolum, is an antipsychotic agent. Zuclopenthixol is a thioxanthene-based neuroleptic with therapeutic actions similar to the phenothiazine antipsychotics. Zuclopenthixol is a typi...
Bromopride Dopamine Antagonist Action Pathway
smpdb.ca/view/SMP0126582Drug actionBromopride is a substituted benzamide. Bromopride in indicated in the treatment of nausea and vomiting, including PONV (post-operative nausea and vomiting), gastroesophageal reflux disease (GERD/GORD), as well as endoscopy preparation an...