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Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1
go.drugbank.com/bio_entities/BE0018277TargetHumansIs also an important negative regulator of oligodentrocyte differentiation and axonal myelination (PubMed:15895088). … Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development (By similarity)
Polypeptides: Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1Synonyms: Leucine-rich repeat and immunoglobulin domain-containing protein 1Aquaporin Z
go.drugbank.com/bio_entities/BE0003818TargetEscherichia coli (strain K12)It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. … Channel that permits osmotically driven movement of water in both directions.
Synonyms: Water channel AqpZS-formylglutathione hydrolase
go.drugbank.com/bio_entities/BE0002283TargetEnzymeHumansSerine hydrolase involved in the detoxification of formaldehyde
Synonyms: Methylumbelliferyl-acetate deacetylaseAcetyl-coenzyme A synthetase
go.drugbank.com/bio_entities/BE0001916TargetSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. Acs undergoes a two-step reaction. … Required for acetate recapture but not for acetate excretion when this organism is grown on ethanolamine (PubMed:16272400).
Synonyms: Acetate--CoA ligaseFunction: acetate-CoA ligase activityCocaine esterase
go.drugbank.com/bio_entities/BE0004712EnzymeHumansShows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine (PubMed:9169443). … Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs (PubMed:9169443).
Synonyms: Methylumbelliferyl-acetate deacetylase 2Coproporphyrin III ferrochelatase
go.drugbank.com/bio_entities/BE0001307TargetBacillus subtilis (strain 168)Has weaker activity with 2,4 disulfonate, deuteroporphyrin and 2,4 hydroxyethyl (PubMed:12761666, PubMed:25646457).
Synonyms: Water-soluble ferrochelataseAquaporin-1
go.drugbank.com/bio_entities/BE0000880TargetTransporterHumansForms a water channel that facilitates the transport of water across cell membranes, playing a crucial role in water homeostasis in various tissues (PubMed:1373524, PubMed:23219802). … In vitro, it shows non-selective gated cation channel activity and may be permeable to cations like K(+) and Na(+) in vivo (PubMed:36949749, PubMed:8703053)
Synonyms: Urine water channelAcetyl-coenzyme A synthetase 2-like, mitochondrial
go.drugbank.com/bio_entities/BE0000746TargetHumansAcetate is the preferred substrate (PubMed:16788062). Can also utilize propionate with a much lower affinity (By similarity). … Involved in thermogenesis under ketogenic conditions, using acetate as a vital fuel when carbohydrate availability is insufficient (By similarity)
Synonyms: Acetate--CoA ligase 2Human Carboxylesterases
go.drugbank.com/bio_entities/BE0010086EnzymeTargetHumansShows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine (PubMed:9169443). … Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs (PubMed:9169443).
Synonyms: Methylumbelliferyl-acetate deacetylase 2, Methylumbelliferyl-acetate deacetylase 1Acetyl-coenzyme A synthetase, cytoplasmic
go.drugbank.com/bio_entities/BE0000350TargetEnzymeHumansAcetate is the preferred substrate (PubMed:10843999, PubMed:28003429, PubMed:38369012, PubMed:39561764). Can also utilize propionate with a much lower affinity (PubMed:38369012). … Nuclear ACSS2 promotes glucose deprivation-induced lysosomal biogenesis and autophagy, tumor cell survival and brain tumorigenesis (PubMed:28552616).
Synonyms: Acetate--CoA ligase