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Displaying results 51 - 60 of 178 in total
  1. Target

    Glycogen synthase kinase-3 beta

    go.drugbank.com/bio_entities/BE0001065
    TargetHumans

    May also mediate the development of insulin resistance by regulating activation of transcription factors (PubMed:8397507). … In skeletal muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis (PubMed:8397507).

  2. Target

    Cyclin-dependent kinase 2

    go.drugbank.com/bio_entities/BE0001072
    TargetHumans

    CTNNB1 phosphorylation regulates insulin internalization (PubMed:21262353). Phosphorylates FOXP3 and negatively regulates its transcriptional activity and protein stability (By similarity).

  3. Target

    Mitochondrial glutamate carrier 1

    go.drugbank.com/bio_entities/BE0002276
    TransporterHumans

    Plays a role in the control of glucose-stimulated insulin secretion (By similarity)

  4. Target

    Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

    go.drugbank.com/bio_entities/BE0002379
    TargetHumans

    Involved in the activation of AKT1 upon stimulation by receptor tyrosine kinases ligands such as EGF, insulin, IGF1, VEGFA and PDGF. … Involved in signaling via insulin-receptor substrate (IRS) proteins. Essential in endothelial cell migration during vascular development through VEGFA signaling, possibly by regulating RhoA activity.

  5. Target

    Phosphatidylinositol 3-kinase regulatory subunit beta

    go.drugbank.com/bio_entities/BE0002383
    TargetHumans

    Promotes nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (By similarity

  6. Target

    Phosphatidylinositol 3-kinase regulatory subunit gamma

    go.drugbank.com/bio_entities/BE0002384
    TargetHumans

    During insulin stimulation, it also binds to IRS-1

  7. Target

    NAD-dependent protein deacetylase sirtuin-1

    go.drugbank.com/bio_entities/BE0002461
    TargetHumans

    Proposed to deacetylate IRS2 thereby facilitating its insulin-induced tyrosine phosphorylation. … Involved in positive regulation of insulin secretion in pancreatic beta cells in response to glucose; the function seems to imply transcriptional repression of UCP2.

  8. Target

    Pituitary adenylate cyclase-activating polypeptide

    go.drugbank.com/bio_entities/BE0003199
    TargetHumans

    Involved in the control of glucose homeostasis, induces insulin secretion by pancreatic beta cells (By similarity).

  9. Target

    Transitional endoplasmic reticulum ATPase

    go.drugbank.com/bio_entities/BE0004572
    TargetHumans

    By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333)

  10. Target

    Potassium voltage-gated channel subfamily B member 1

    go.drugbank.com/bio_entities/BE0004721
    TargetHumans

    Contributes to the regulation of glucose-induced action potential amplitude and duration in pancreatic beta cells, hence limiting calcium influx and insulin secretion (PubMed:23161216). … May confer neuroprotection in response to hypoxia/ischemic insults by suppressing pyramidal neurons hyperexcitability in hippocampal and cortical regions (By similarity).