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Displaying results 601 - 610 of 1186 in total
  1. Target

    Fibroblast growth factor receptor 4

    go.drugbank.com/bio_entities/BE0001203
    TargetHumans

    FGFR4 signaling is down-regulated by receptor internalization and degradation; MMP14 promotes internalization and degradation of FGFR4. … Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of

    Polypeptides: Fibroblast growth factor receptor 4
  2. Target

    Neuropeptide Y receptor type 2

    go.drugbank.com/bio_entities/BE0002419
    TargetHumans

    Receptor activation by ligands also leads to an increase of intracellular Ca(2+) levels (PubMed:7559383, PubMed:7592910). … Receptor for neuropeptide Y (NPY) and peptide YY (PYY) (PubMed:7592910, PubMed:7559383, PubMed:35507650, PubMed:36525977, PubMed:38882210).

    Polypeptides: Neuropeptide Y receptor type 2Synonyms: Y2 receptor, NPY-Y2 receptor
  3. Target

    Atrial natriuretic peptide receptor 3

    go.drugbank.com/bio_entities/BE0002426
    TargetHumans

    May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. … Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP.

    Polypeptides: Atrial natriuretic peptide receptor 3Synonyms: Atrial natriuretic peptide receptor type C, Atrial natriuretic peptide clearance receptor
  4. Target

    Interleukin-6 receptor subunit alpha

    go.drugbank.com/bio_entities/BE0002859
    TargetHumans

    Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal (PubMed:28265003). Signal activation necessitate an association with IL6ST.

    Polypeptides: Interleukin-6 receptor subunit alphaSynonyms: IL-6 receptor subunit alpha
  5. Target

    Signal recognition particle receptor FtsY

    go.drugbank.com/bio_entities/BE0003264
    TargetThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)

    Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).

    Polypeptides: Signal recognition particle receptor FtsYSynonyms: SRP receptor
  6. Target

    Interleukin-5 receptor subunit alpha

    go.drugbank.com/bio_entities/BE0003471
    TargetHumans

    Cell surface receptor that plays an important role in the survival, differentiation, and chemotaxis of eosinophils (PubMed:9378992). … Heterodimeric receptor activation leads to JAK2 stimulation and subsequent activation of the JAK-STAT pathway (PubMed:9516124)

    Polypeptides: Interleukin-5 receptor subunit alphaSynonyms: IL-5 receptor subunit alpha
  7. Target

    Prostaglandin E2 receptor EP4 subtype

    go.drugbank.com/bio_entities/BE0003522
    TargetHumans

    Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle.

    Polypeptides: Prostaglandin E2 receptor EP4 subtypeSynonyms: PGE receptor EP4 subtype, Prostanoid EP4 receptor
  8. Target

    TGF-beta receptor type-1

    go.drugbank.com/bio_entities/BE0003782
    TargetHumans

    Transmembrane serine/threonine kinase forming with the TGF-beta type II serine/threonine kinase receptor, TGFBR2, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. … Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4.

    Polypeptides: TGF-beta receptor type-1Synonyms: TGF-beta receptor type I, TGF-beta type I receptor
  9. Target

    Ephrin type-B receptor 2

    go.drugbank.com/bio_entities/BE0004549
    TargetHumans

    Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. … The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling.

    Polypeptides: Ephrin type-B receptor 2Synonyms: Tyrosine-protein kinase receptor EPH-3
  10. Target

    Discoidin domain-containing receptor 2

    go.drugbank.com/bio_entities/BE0004741
    TargetHumans

    It functions as a cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation.

    Polypeptides: Discoidin domain-containing receptor 2Synonyms: Discoidin domain receptor 2, Receptor protein-tyrosine kinase TKT