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Displaying results 611 - 620 of 3730 in total
  1. Target

    Alpha-2B adrenergic receptor

    go.drugbank.com/bio_entities/BE0000572
    TargetHumans

    Alpha-2 adrenergic receptors are G protein-coupled receptors for catecholamines that activate G(i/o) protein pathway, thereby promoting adenylyl cyclase inhibition, ERK1/2 stimulation, and voltage-gated calcium channels suppression (PubM...

    Polypeptides: Alpha-2B adrenergic receptorSynonyms: Alpha-2 adrenergic receptor subtype C2
  2. Target

    Hydroxycarboxylic acid receptor 2

    go.drugbank.com/bio_entities/BE0000635
    TargetHumans

    Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated … Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis

    Polypeptides: Hydroxycarboxylic acid receptor 2Synonyms: Niacin receptor 1, Nicotinic acid receptor
  3. Target

    5-hydroxytryptamine receptor 1D

    go.drugbank.com/bio_entities/BE0000659
    TargetHumans

    G protein-coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:10452531, PubMed:1565658, PubMed:1652050, PubMed:33762731). … Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed

    Polypeptides: 5-hydroxytryptamine receptor 1DSynonyms: Serotonin receptor 1D, Serotonin 1D alpha receptor
  4. Target

    Retinoic acid receptor alpha

    go.drugbank.com/bio_entities/BE0000663
    TargetHumans

    Receptor for retinoic acid (PubMed:16417524, PubMed:19850744, PubMed:20215566, PubMed:21152046, PubMed:37478846).

    Polypeptides: Retinoic acid receptor alphaSynonyms: Nuclear receptor subfamily 1 group B member 1
  5. Target

    Thyroid hormone receptor alpha

    go.drugbank.com/bio_entities/BE0000687
    TargetHumans

    Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine

    Polypeptides: Thyroid hormone receptor alphaSynonyms: Nuclear receptor subfamily 1 group A member 1
  6. Target

    Cysteinyl leukotriene receptor 1

    go.drugbank.com/bio_entities/BE0000705
    TargetHumans

    Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma. … This response is mediated via a G protein that activates a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTD4 >> LTE4 = LTC4 >> LTB4

    Polypeptides: Cysteinyl leukotriene receptor 1Synonyms: LTD4 receptor, G protein-coupled receptor HG55
  7. Target

    Epidermal growth factor receptor

    go.drugbank.com/bio_entities/BE0000767
    TargetEnzymeHumans

    Positively regulates cell migration via interaction with CCDC88A/GIV which retains EGFR at the cell membrane following ligand stimulation, promoting EGFR signaling which triggers cell migration (PubMed … Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling (PubMed:11602604).

    Polypeptides: Epidermal growth factor receptorSynonyms: Receptor tyrosine-protein kinase erbB-1
  8. Target

    Metabotropic glutamate receptor 1

    go.drugbank.com/bio_entities/BE0000824
    TargetHumans

    G protein-coupled receptor for glutamate. … Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors.

    Polypeptides: Metabotropic glutamate receptor 1Function: adenylate cyclase inhibiting G protein-coupled glutamate receptor activity
  9. Target

    Metabotropic glutamate receptor 4

    go.drugbank.com/bio_entities/BE0000833
    TargetHumans

    G protein-coupled receptor for glutamate. … Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors.

    Polypeptides: Metabotropic glutamate receptor 4Function: adenylate cyclase inhibiting G protein-coupled glutamate receptor activity
  10. Target

    Metabotropic glutamate receptor 8

    go.drugbank.com/bio_entities/BE0000835
    TargetHumans

    G protein-coupled receptor for glutamate. … Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase.

    Polypeptides: Metabotropic glutamate receptor 8Function: G protein-coupled receptor activity