Search

Displaying results 6351 - 6360 of 10000 in total
  1. Target

    Apoptosis regulator Bcl-2

    go.drugbank.com/bio_entities/BE0010919
    TargetRat

    Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system...

    Polypeptides: Apoptosis regulator Bcl-2Synonyms: Bcl-2
  2. Target

    CCN family member 2

    go.drugbank.com/bio_entities/BE0013178
    TargetHumans

    Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Is involved in the stimulation of osteoblast differentiation and has a critical role in osteogenes...

    Polypeptides: CCN family member 2Synonyms: Cellular communication network factor 2
  3. Target

    Lysosome membrane protein 2

    go.drugbank.com/bio_entities/BE0014604
    TransporterHumans

    Acts as a lysosomal receptor for glucosylceramidase (GBA1) targeting

    Polypeptides: Lysosome membrane protein 2Synonyms: CD36 antigen-like 2, Scavenger receptor class B member 2
  4. Target

    Pantothenate kinase 2, mitochondrial

    go.drugbank.com/bio_entities/BE0019249
    EnzymeHumans

    Mitochondrial isoform that catalyzes the phosphorylation of pantothenate to generate 4'-phosphopantothenate in the first and rate-determining step of coenzyme A (CoA) synthesis (PubMed:15659606, PubMed:16272150, PubMed:17242360, PubMed:1...

    Polypeptides: Pantothenate kinase 2, mitochondrialSynonyms: Pantothenic acid kinase 2
  5. Target

    Inositol-pentakisphosphate 2-kinase

    go.drugbank.com/bio_entities/BE0019971
    EnzymeHumans

    Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).

    Polypeptides: Inositol-pentakisphosphate 2-kinaseSynonyms: InsP5 2-kinase, Ins(1,3,4,5,6)P5 2-kinase
  6. Target

    rRNA methyltransferase 2, mitochondrial

    go.drugbank.com/bio_entities/BE0020789
    TargetHumans

    S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methyluridine at position 1369 (Um1369) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU … This activity may require prior 2'-O-methylguanosine modification at position 1370 (Gm1370) by MRM3 (PubMed:35177605).

    Polypeptides: rRNA methyltransferase 2, mitochondrialSynonyms: Protein ftsJ homolog 2, 16S rRNA [Um1369] 2'-O-methyltransferase
  7. Target

    Insulin receptor substrate 2

    go.drugbank.com/bio_entities/BE0021286
    TargetHumans

    Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:25879670). Plays therefore an important ro...

    Polypeptides: Insulin receptor substrate 2Synonyms: IRS-2
  8. Drug

    Aflibercept

    go.drugbank.com/drugs/DB08885
    ApprovedInvestigational

    [A261281,A261286] Due to the 2 fused VEGFR, aflibercept has a higher affinity to the cognate ligands than the endogenous individual receptor. … gamma 1 (IgG1).

    Products: ZALTRAP CONCENTRATE FOR SOLUTION FOR INFUSION 25 MG/ML, EYLEA 40 MG/ML INTRAVITREAL ENJEKSIYON ICIN COZELTI ICEREN FLAKON, 1 ADET
  9. Pathway

    Acylcarnitine (5Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(1E,3S)-3-hydroxy-5-phenylpent-1-en-1-yl]-5-oxocyclopentyl]hept-5-enoylcarnitine

    smpdb.ca/view/SMP0123487
    Metabolic

    hydroxy-2-[(1E,3S)-3-hydroxy-5-phenylpent-1-en-1-yl]-5-oxocyclopentyl]hept-5-enoylcarnitine. … (5Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(1E,3S)-3-hydroxy-5-phenylpent-1-en-1-yl]-5-oxocyclopentyl]hept-5-enoylcarnitine is an acylcarnitine.

    Drugs: Biotin · Adenosine phosphate · ATP · Levocarnitine · Magnesium cation · Pyrophosphoric acid +1 more
    Enzymes: Solute carrier family 22 member 5, Carnitine O-palmitoyltransferase 2, mitochondrial
  10. Drug

    Pembrolizumab

    go.drugbank.com/drugs/DB09037
    ApprovedInvestigational

    It was generated by grafting the variable sequences of a very high-affinity mouse antihuman PD-1 antibody onto a human IgG4-kappa isotype containing a stabilizing S228P Fc mutation. … Pembrolizumab is a highly selective IgG4-kappa humanized monoclonal antibody against PD-1 receptors.

    Categories: PD-1/PD-L1 (Programmed cell death protein 1/death ligand 1) inhibitors, PD-1/PDL-1 (Programmed cell death protein 1/death ligand 1) inhibitorsProducts: KEYTRUDA® 100 MG, KEYTRUDA 100 MG/4 ML IV INFUZYONLUK COZELTI İÇEREN FLAKON, 1 ADET