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Sphingosine 1-phosphate receptor 5
go.drugbank.com/bio_entities/BE0002432TargetHumansReceptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues.
Polypeptides: Sphingosine 1-phosphate receptor 5Synonyms: S1P receptor 5, S1P receptor Edg-8Neuropeptide Y receptor type 5
go.drugbank.com/bio_entities/BE0002452TargetHumansReceptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake.
Polypeptides: Neuropeptide Y receptor type 5Synonyms: Y5 receptor, NPY-Y5 receptorEphrin type-B receptor 4
go.drugbank.com/bio_entities/BE0002453TargetHumansThe signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. … Receptor tyrosine kinase which binds promiscuously to transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells.
Polypeptides: Ephrin type-B receptor 4Free fatty acid receptor 4
go.drugbank.com/bio_entities/BE0003399TargetHumansActs as a receptor for omega-3 polyunsaturated fatty acids (PUFAs) at primary cilium of perivascular preadipocytes, initiating an adipogenic program via cAMP and CTCF-dependent chromatin remodeling that … After LCFAs binding, associates with beta-arrestin ARRB2 that acts as an adapter protein coupling the receptor to specific downstream signaling pathways, as well as mediating receptor endocytosis (PubMed
Polypeptides: Free fatty acid receptor 4Synonyms: G protein-coupled receptor 120, G protein-coupled receptor 129Melanin-concentrating hormone receptor 1
go.drugbank.com/bio_entities/BE0003478TargetHumansG protein-coupled receptor for melanin-concentrating hormone (MCH) that signals primarily through G(i/o) to inhibit adenylyl cyclase, and can additionally couple to G(q/11) to stimulate phospholipase C
Polypeptides: Melanin-concentrating hormone receptor 1Synonyms: MCH receptor 1, G protein-coupled receptor 24Nuclear receptor-interacting protein 1
go.drugbank.com/bio_entities/BE0003742TargetHumansModulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1. Also modulates transcriptional repression by nuclear hormone receptors. Positive regulator of the circadian clock gene expression: stimulates transc...
Polypeptides: Nuclear receptor-interacting protein 1Synonyms: Receptor-interacting protein 140Very low-density lipoprotein receptor
go.drugbank.com/bio_entities/BE0004020TargetCarrierHumansLater, mediates a stop signal for migrating neurons, preventing them from entering the marginal zone (By similarity) … Multifunctional cell surface receptor that binds VLDL and transports it into cells by endocytosis and therefore plays an important role in energy metabolism.
Polypeptides: Very low-density lipoprotein receptorSynonyms: VLDL receptorEphrin type-A receptor 7
go.drugbank.com/bio_entities/BE0004140TargetHumansReceptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. … The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling.
Polypeptides: Ephrin type-A receptor 7Interleukin-1 receptor antagonist protein
go.drugbank.com/bio_entities/BE0004735TargetHumansAnti-inflammatory antagonist of interleukin-1 family of proinflammatory cytokines such as interleukin-1beta/IL1B and interleukin-1alpha/IL1A. Protects from immune dysregulation and uncontrolled systemic inflammation triggered by IL1 for ...
Polypeptides: Interleukin-1 receptor antagonist proteinG protein-coupled receptor 35
go.drugbank.com/bio_entities/BE0005562TargetHumansG protein-coupled receptor that binds to several ligands including the tryptophan metabolite kynurenic acid (KYNA), lysophosphatidic acid (LPA) or 5-hydroxyindoleacetic acid (5-HIAA) with high affinity … Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed
Polypeptides: G protein-coupled receptor 35Synonyms: KYNA receptor, Kynurenic acid receptor