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Displaying results 661 - 670 of 3730 in total
  1. Target

    5-hydroxytryptamine receptor 1F

    go.drugbank.com/bio_entities/BE0000460
    TargetHumans

    Receptor for lasmiditan, a drug for the treatment of acute migraine (PubMed:34239069). … Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed

    Polypeptides: 5-hydroxytryptamine receptor 1FSynonyms: Serotonin receptor 1F
  2. Target

    5-hydroxytryptamine receptor 1E

    go.drugbank.com/bio_entities/BE0000476
    TargetHumans

    Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed … G protein-coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:14744596, PubMed:1513320, PubMed:1608964, PubMed:1733778, PubMed:21422162, PubMed:33762731).

    Polypeptides: 5-hydroxytryptamine receptor 1ESynonyms: Serotonin receptor 1E
  3. Target

    Low-density lipoprotein receptor

    go.drugbank.com/bio_entities/BE0000499
    TargetCarrierHumans

    In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits.

    Polypeptides: Low-density lipoprotein receptorSynonyms: LDL receptor
  4. Target

    Extracellular calcium-sensing receptor

    go.drugbank.com/bio_entities/BE0000509
    TargetHumans

    Acts as an activator of the NLRP3 inflammasome via G(i)/G(o)-mediated signaling: down-regulation of cyclic AMP (cAMP) relieving NLRP3 inhibition by cAMP (PubMed:32843625). … full receptor activation (PubMed:27386547, PubMed:27434672, PubMed:32817431, PubMed:33603117, PubMed:34194040).

    Polypeptides: Extracellular calcium-sensing receptorSynonyms: Parathyroid cell calcium-sensing receptor 1
  5. Target

    5-hydroxytryptamine receptor 2C

    go.drugbank.com/bio_entities/BE0000533
    TargetHumans

    Regulates neuronal activity via the activation of short transient receptor potential calcium channels in the brain, and thereby modulates the activation of pro-opiomelanocortin neurons and the release … G protein-coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:12970106, PubMed:18703043, PubMed:19057895, PubMed:29398112, PubMed:7895773).

    Polypeptides: 5-hydroxytryptamine receptor 2CSynonyms: Serotonin receptor 2C, 5-hydroxytryptamine receptor 1C
  6. Target

    Alpha-1B adrenergic receptor

    go.drugbank.com/bio_entities/BE0000575
    TargetHumans

    Alpha-1 adrenergic receptors are G protein-coupled receptors for catecholamines that signal through the G(q) family of G proteins, including G(q) and G(11). Upon activation, they stimulate the phosphatidylinositol-calcium second messenge...

    Polypeptides: Alpha-1B adrenergic receptorFunction: alpha1-adrenergic receptor activity
  7. Target

    Prostaglandin F2-alpha receptor

    go.drugbank.com/bio_entities/BE0000610
    TargetHumans

    Receptor for prostaglandin F2-alpha (PGF2-alpha). The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. … Isoforms 2 to 7 do not bind PGF2-alpha but are proposed to modulate signaling by participating in variant receptor complexes; heterodimers between isoform 1 and isoform 5 are proposed to be a receptor

    Polypeptides: Prostaglandin F2-alpha receptorSynonyms: PGF receptor, PGF2-alpha receptor
  8. Target

    5-hydroxytryptamine receptor 7

    go.drugbank.com/bio_entities/BE0000650
    TargetHumans

    G protein-coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen (PubMed:35714614, PubMed:8226867). … Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (PubMed:35714614, PubMed:8226867

    Polypeptides: 5-hydroxytryptamine receptor 7Synonyms: Serotonin receptor 7
  9. Target

    Beta-2 adrenergic receptor

    go.drugbank.com/bio_entities/BE0000694
    TargetHumans

    G protein-coupled receptor for catecholamines that couples to both G(s) and G(i) proteins, activating bifurcated signaling pathways (PubMed:2831218, PubMed:7915137).

    Polypeptides: Beta-2 adrenergic receptor
  10. Target

    Interferon gamma receptor 1

    go.drugbank.com/bio_entities/BE0000711
    TargetHumans

    Associates with transmembrane accessory factor IFNGR2 to form a functional receptor (PubMed:10986460, PubMed:2971451, PubMed:7615558, PubMed:7617032, PubMed:7673114). … Receptor subunit for interferon gamma/INFG that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation (PubMed:20015550

    Polypeptides: Interferon gamma receptor 1Synonyms: IFN-gamma receptor 1, Interferon gamma receptor alpha-chain