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Aromatic-L-amino-acid decarboxylase
go.drugbank.com/bio_entities/BE0002151TargetEnzymeHumansCatalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine and L-5-hydroxytryptophan to serotonin
Polypeptides: Aromatic-L-amino-acid decarboxylaseCyclopropane mycolic acid synthase 1
go.drugbank.com/bio_entities/BE0003738TargetMycobacterium tuberculosisCyclopropanated mycolic acids are key factors participating in cell envelope permeability, host immunomodulation and persistence. … Catalyzes the conversion of a double bond to a cyclopropane ring at the distal position of an alpha mycolic acid via the transfer of a methylene group from S-adenosyl-L-methionine.
Polypeptides: Cyclopropane mycolic acid synthase 1Synonyms: Cyclopropane fatty acid synthase, Mycolic acid methyltransferaseFatty acid-binding protein, liver
go.drugbank.com/bio_entities/BE0003998CarrierTargetHumansBinds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport (By similarity)
Polypeptides: Fatty acid-binding protein, liverSynonyms: Fatty acid-binding protein 1, Liver-type fatty acid-binding proteinAcid-sensing ion channel 3
go.drugbank.com/bio_entities/BE0004768TargetHumansAs a neuronal acid sensor, probably contributes to mechanoreception, acid nociception, and heat nociception (By similarity). … ASIC3 is more sensitive to protons and gates between closed, open, and desensitized states faster than other ASICs (By similarity).
Polypeptides: Acid-sensing ion channel 3Free fatty acid receptor 3
go.drugbank.com/bio_entities/BE0010132TargetHumansIn omnivorous mammals, the short chain fatty acids acetate, propionate and butyrate are produced primarily by the gut microbiome that metabolizes dietary fibers. … G protein-coupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that plays a role in the regulation of whole-body energy homeostasis
Polypeptides: Free fatty acid receptor 3Polyunsaturated fatty acid lipoxygenase ALOX12
go.drugbank.com/bio_entities/BE0012732TargetHumansCatalyzes the regio and stereo-specific incorporation of molecular oxygen into free and esterified polyunsaturated fatty acids generating lipid hydroperoxides that can be further reduced to the corresponding … Due to its role in regulating both the expression of the vascular endothelial growth factor (VEGF, an angiogenic factor involved in the survival and metastasis of solid tumors) and the expression of integrin
Polypeptides: Polyunsaturated fatty acid lipoxygenase ALOX12Fatty-acid amide hydrolase 2
go.drugbank.com/bio_entities/BE0015331EnzymeHumansthe sleep-inducing lipid oleamide ((9Z)-octadecenamide), the endocannabinoid anandamide (N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine), as well as other fatty amides, to their corresponding fatty acids
Polypeptides: Fatty-acid amide hydrolase 2Function: fatty acid amide hydrolase activityCationic amino acid transporter 4
go.drugbank.com/bio_entities/BE0000052TargetHumansInvolved in the transport of the cationic amino acids (arginine, lysine and ornithine)
Polypeptides: Cationic amino acid transporter 4Function: basic amino acid transmembrane transporter activityCationic amino acid transporter 3
go.drugbank.com/bio_entities/BE0000136TargetHumansUniporter that mediates the uptake of cationic L-amino acids such as L-arginine, L-lysine and L-ornithine (PubMed:11591158). … The transport is sodium ions- and pH-independent, moderately trans-stimulated and is mediated by passive diffusion (PubMed:11591158)
Polypeptides: Cationic amino acid transporter 3Synonyms: Cationic amino acid transporter y+Acid-sensing ion channel 1
go.drugbank.com/bio_entities/BE0000353TargetTransporterHumansRegulates more or less directly intracellular calcium concentration and CaMKII phosphorylation, and thereby the density of dendritic spines. … Upon extracellular pH drop this channel elicits transient, fast activating, and completely desensitizing inward currents (PubMed:21036899).
Polypeptides: Acid-sensing ion channel 1