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Displaying results 61 - 70 of 138749 in total
  1. Pathway

    Indigotindisulfonic acid Drug Metabolism

    smpdb.ca/view/SMP0130815
    Metabolic

    Indigotindisulfonic acid passes through the liver and is then excreted from the body mainly through the kidney. … Indigotindisulfonic acid is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis.

    Drugs: Indigotindisulfonic acid
  2. Pathway

    Acetylsalicylic Acid Action Pathway

    smpdb.ca/view/SMP0000083
    Drug action

    COX-1 and -2 catalyze the conversion of arachidonic acid to prostaglandin G2 and prostaglandin G2 to prostaglandin H2. … Acetylsalicylic acid, also known as ASA or aspirin, belongs to a class of drugs known as non-steroidal anti-inflammatory drugs (NSAIDs).

    Drugs: Glutamic acid · Glutathione · Dinoprostone · Acetylsalicylic acid · Calcium · Magnesium cation +5 more
  3. Pathway

    Phytanic Acid Peroxisomal Oxidation

    smpdb.ca/view/SMP0000450
    Metabolic

    Phytanic acid, a branched chain fatty acid, is an important component of fatty acid intake, occuring in meat, fish and dairy products. … Due to its methylation, it cannot be a substrate for acyl-CoA dehydrogenase and cannot enter the mitochondrial beta oxidation pathway.

    Drugs: Ascorbic acid · Succinic acid · NADH · ATP · Magnesium cation · Iron +2 more
  4. Pathway

    Salicylic Acid Action Pathway

    smpdb.ca/view/SMP0000709
    Drug action

    It can be used to reduce pain and fever. Salicylic acid can block prostaglandin synthesis by the action of inhibition of prostaglandin G/H synthase 1 and 2. … Prostaglandin G/H synthase 1 and 2 catalyze the arachidonic acid to prostaglandin G2, and also catalyze prostaglandin G2 to prostaglandin H2 in the metabolism pathway.

    Drugs: Glutamic acid · Glutathione · Dinoprostone · Salicylic acid · Calcium · Magnesium cation +5 more
  5. Pathway

    Lysophosphatidic Acid LPA5 Signalling

    smpdb.ca/view/SMP0063757
    Signaling

    Lysophosphatidic acid (LPA) is a water-soluble phospholipid derivative and a potent signalling molecule that binds to six known lysophosphatidic acid receptors (LPARs), named LPA1-LPA6. … LPC, LPE, LPS) into LPA via autotaxin (ATX/Enpp2) and (2) the conversion of phosphatidic acid (PA) into LPA via phospholipase A1 or A2 (PLA1/PLA2).

    Drugs: ATP · Calcium · Magnesium cation · Cyclic adenosine monophosphate · Pyrophosphoric acid
    Enzymes: Lysophosphatidic acid receptor 5
  6. Pathway

    Lysophosphatidic Acid LPA6 Signalling

    smpdb.ca/view/SMP0063759
    Signaling

    Lysophosphatidic acid (LPA) is a water-soluble phospholipid derivative and a potent signalling molecule that binds to six known lysophosphatidic acid receptors (LPARs), named LPA1-LPA6. … LPC, LPE, LPS) into LPA via autotaxin (ATX/Enpp2) and (2) the conversion of phosphatidic acid (PA) into LPA via phospholipase A1 or A2 (PLA1/PLA2).

    Drugs: ATP · Magnesium cation · Cyclic adenosine monophosphate · Pyrophosphoric acid
    Enzymes: Lysophosphatidic acid receptor 6
  7. Pathway

    Clorazepic Acid Action Pathway

    smpdb.ca/view/SMP0126122
    Drug action

    Clorazepic acid or clorazepate is a benzodiazepine used to treat anxiety, partial seizures, and alcohol withdrawal. … Some side effects of using clorazepic acid may include dizziness, nervousness, blurred vision, and headache.

    Drugs: Pyridoxal phosphate · Glutamic acid · ATP · Clorazepic acid · Calcium · Magnesium cation +4 more
    Enzymes: Vesicular inhibitory amino acid transporter, Gamma-aminobutyric acid type B receptor subunit 2
  8. Pathway

    Clodronic Acid Action Pathway

    smpdb.ca/view/SMP0126307
    Drug action

    Clodronic acid is a bisphosphonate used for the treatment of osteoporosis in women experiencing menopause, hypercalcemia malignancy and osteolysis. … Usually administered intravenously, it is not metabolized and is eliminated via the urine unchanged.

    Drugs: ATP · Clodronic acid · Magnesium cation · Dimethylallyl Diphosphate · Geranyl Diphosphate · Pyrophosphoric acid +3 more
    Enzymes: Acetyl-CoA acetyltransferase, mitochondrial
  9. Pathway

    Etidronic Acid Action Pathway

    smpdb.ca/view/SMP0126349
    Drug action

    Etidronic acid binds to hydroxylapatite and during bone resorption, it is released and taken up into the osteoclast by endocytosis. … Etidronic Acid is a first-generation bisphosphonate used for the treatment of osteoporosis, preventing bone resorption from osteoclast activity.

    Drugs: ATP · Etidronic acid · Magnesium cation · Dimethylallyl Diphosphate · Geranyl Diphosphate · Pyrophosphoric acid +3 more
    Enzymes: Acetyl-CoA acetyltransferase, mitochondrial
  10. Pathway

    Tiludronic Acid Action Pathway

    smpdb.ca/view/SMP0126351
    Drug action

    Tiludronic acid is a first-generation bisphosphonate used to treat Paget's disease, similar to etidronic acid and clodronic acid. … Tiludronic acid binds to hydroxylapatite in the bone, during bone resorption it is released and taken up by osteoclasts through endocytosis.

    Drugs: ATP · Tiludronic acid · Magnesium cation · Dimethylallyl Diphosphate · Geranyl Diphosphate · Pyrophosphoric acid +3 more
    Enzymes: Acetyl-CoA acetyltransferase, mitochondrial