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Displaying results 61 - 70 of 485 in total
  1. Target

    Aromatic-L-amino-acid decarboxylase

    go.drugbank.com/bio_entities/BE0002151
    TargetEnzymeHumans

    Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine and L-5-hydroxytryptophan to serotonin

    Polypeptides: Aromatic-L-amino-acid decarboxylase
  2. Target

    Acidic amino acid decarboxylase GADL1

    go.drugbank.com/bio_entities/BE0002163
    TargetHumans

    May catalyze the decarboxylation of L-aspartate, 3-sulfino-L-alanine (cysteine sulfinic acid), and L-cysteate to beta-alanine, hypotaurine and taurine, respectively. … Does not exhibit any decarboxylation activity toward glutamate

    Polypeptides: Acidic amino acid decarboxylase GADL1Synonyms: Cysteine sulfinic acid decarboxylase
  3. Target

    Cyclopropane mycolic acid synthase 1

    go.drugbank.com/bio_entities/BE0003738
    TargetMycobacterium tuberculosis

    Catalyzes the conversion of a double bond to a cyclopropane ring at the distal position of an alpha mycolic acid via the transfer of a methylene group from S-adenosyl-L-methionine. … Cyclopropanated mycolic acids are key factors participating in cell envelope permeability, host immunomodulation and persistence.

    Polypeptides: Cyclopropane mycolic acid synthase 1Synonyms: Cyclopropane fatty acid synthase, Mycolic acid methyltransferase
  4. Target

    Fatty acid-binding protein, liver

    go.drugbank.com/bio_entities/BE0003998
    CarrierTargetHumans

    Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport (By similarity)

    Polypeptides: Fatty acid-binding protein, liverSynonyms: Fatty acid-binding protein 1, Liver-type fatty acid-binding protein
  5. Target

    Acid-sensing ion channel 3

    go.drugbank.com/bio_entities/BE0004768
    TargetHumans

    As a neuronal acid sensor, probably contributes to mechanoreception, acid nociception, and heat nociception (By similarity). … ASIC3 is more sensitive to protons and gates between closed, open, and desensitized states faster than other ASICs (By similarity).

    Polypeptides: Acid-sensing ion channel 3
  6. Target

    Free fatty acid receptor 3

    go.drugbank.com/bio_entities/BE0010132
    TargetHumans

    May also indirectly regulate the production of LEP/Leptin, a hormone acting on the CNS to inhibit food intake, in response to the presence of short-chain fatty acids in the intestine. … In omnivorous mammals, the short chain fatty acids acetate, propionate and butyrate are produced primarily by the gut microbiome that metabolizes dietary fibers.

    Polypeptides: Free fatty acid receptor 3
  7. Target

    Polyunsaturated fatty acid lipoxygenase ALOX12

    go.drugbank.com/bio_entities/BE0012732
    TargetHumans

    Catalyzes the regio and stereo-specific incorporation of molecular oxygen into free and esterified polyunsaturated fatty acids generating lipid hydroperoxides that can be further reduced to the corresponding … Due to its role in regulating both the expression of the vascular endothelial growth factor (VEGF, an angiogenic factor involved in the survival and metastasis of solid tumors) and the expression of integrin

    Polypeptides: Polyunsaturated fatty acid lipoxygenase ALOX12
  8. Target

    Fatty-acid amide hydrolase 2

    go.drugbank.com/bio_entities/BE0015331
    EnzymeHumans

    their corresponding fatty acids, thereby regulating the signaling functions of these molecules (PubMed:17015445, PubMed:19926788). … Hydrolyzes monounsaturated substrate anandamide preferentially as compared to polyunsaturated substrates

    Polypeptides: Fatty-acid amide hydrolase 2Function: fatty acid amide hydrolase activity
  9. Target

    Cationic amino acid transporter 4

    go.drugbank.com/bio_entities/BE0000052
    TargetHumans

    Involved in the transport of the cationic amino acids (arginine, lysine and ornithine)

    Polypeptides: Cationic amino acid transporter 4Function: basic amino acid transmembrane transporter activity
  10. Target

    Cationic amino acid transporter 3

    go.drugbank.com/bio_entities/BE0000136
    TargetHumans

    Uniporter that mediates the uptake of cationic L-amino acids such as L-arginine, L-lysine and L-ornithine (PubMed:11591158). … The transport is sodium ions- and pH-independent, moderately trans-stimulated and is mediated by passive diffusion (PubMed:11591158)

    Polypeptides: Cationic amino acid transporter 3Synonyms: Cationic amino acid transporter y+