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Cell growth-regulating nucleolar protein
go.drugbank.com/bio_entities/BE0008958TargetMousePlays a role in the maintenance of the appropriate processing of 47S/45S pre-rRNA to 32S/30S pre-rRNAs and their subsequent processing to produce 18S and 28S rRNAs (By similarity). … Negatively regulates the antiviral innate immune response by targeting IRF3 and impairing its DNA-binding activity (By similarity).
Synonyms: Protein expressed in male leptotene and zygotene spermatocytes 264Zinc transporter ZIP5
go.drugbank.com/bio_entities/BE0009888TransporterHumansUniporter that transports zinc(2+) into polarized cells of enterocytes, pancreatic acinar and endoderm cells across the basolateral membrane and participates, notably, in zinc excretion from the intestine … The transport mechanism is temperature- and concentration-dependent and saturable (By similarity). In addition, is also a high affinity copper transporter in vitro (PubMed:36454509).
Synonyms: Zrt- and Irt-like protein 5Stabilin-2
go.drugbank.com/bio_entities/BE0004948TargetHumansBinds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. … Hyaluronan receptor that binds to and mediates endocytosis of hyaluronic acid (HA).
Synonyms: FAS1 EGF-like and X-link domain-containing adhesion molecule 2, Fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavenger receptor 2Prolyl 3-hydroxylase 1
go.drugbank.com/bio_entities/BE0002202TargetEnzymeHumansHas prolyl 3-hydroxylase activity and catalyzes the post-translational formation of 3-hydroxyproline in -Xaa-Pro-Gly- sequences in pro-collagen chains, a critical step for the formation of mature collagen
Synonyms: Leucine- and proline-enriched proteoglycan 1Zinc transporter ZIP11
go.drugbank.com/bio_entities/BE0009906TransporterHumansThe transport mechanism remains to be elucidated
Synonyms: Zrt- and Irt-like protein 11Protein phosphatase 1 regulatory subunit 15A
go.drugbank.com/bio_entities/BE0011888TargetHumansPlays an essential role in autophagy by tuning translation during starvation, thus enabling lysosomal biogenesis and a sustained autophagic flux (PubMed:32978159). … by stress-inducible kinases and facilitating recovery of cells from stress (PubMed:26095357, PubMed:26742780).
Synonyms: Growth arrest and DNA damage-inducible protein GADD34Alpha-2-macroglobulin
go.drugbank.com/bio_entities/BE0000910TargetCarrierHumansFollowing cleavage in the bait region, a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase … Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism.
Synonyms: C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1
go.drugbank.com/bio_entities/BE0000931TargetHumansHas ADP-ribosyltransferase activity toward GLP1R
Synonyms: ADP-ribosyltransferase C2 and C3 toxin-like 1SPARC
go.drugbank.com/bio_entities/BE0002145TargetHumansAppears to regulate cell growth through interactions with the extracellular matrix and cytokines. … There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity
Synonyms: Secreted protein acidic and rich in cysteineZinc transporter ZIP4
go.drugbank.com/bio_entities/BE0009894TransporterHumansAlso exhibits polyspecific binding and transport of Cu(2+), Cd(2+) and possibly Ni(2+) but at higher concentrations (PubMed:22242765, PubMed:31914589) … Plays an essential role for dietary zinc uptake from small intestine (By similarity). The Zn(2+) uniporter activity is regulated by zinc availability (PubMed:17202136, PubMed:32348750).
Synonyms: Zrt- and Irt-like protein 4