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Metabolism and Physiological Effects of 3-Deoxyglucosone
smpdb.ca/view/SMP0125516MetabolicIt normally is synthesized and accumulates with high serum glucose due to diabetes. 3-deoxyglucosone causes cell apoptosis and neurotoxicity. … An amino acid like arginine or lysine are combined with glucose to make a schiff base and water. The schiff base is unstable so it becomes the stable amadori product.
Metabolism and Physiological Effects of N-Acetylproline
smpdb.ca/view/SMP0126660MetabolicIn addition to the NAT enzymes and protein-based acetylation, N-acetylation of free proline can also occur. … N-acetylproline in the body can cause kidney damage and contribute to tumorigenesis, L-proline can be obtained from the diet from foods that are high in protein such as meat, fish, and dairy.
Metabolism and Physiological Effects of N-Acetylvaline
smpdb.ca/view/SMP0126701MetabolicIn addition to the NAT enzymes and protein-based acetylation, N-acetylation of free valine can also occur. … N-acetyltransferase (NAT) is an enzyme that catalyzes the transfer of acetyl groups from acetyl-CoA to arylamines, arylhydroxylamines and arylhydrazines.
Drugs: ValineMetabolism and Physiological Effects of N-Acetylmethionine
smpdb.ca/view/SMP0126707MetabolicIn addition to the NAT enzymes and protein-based acetylation, N-acetylation of free methionine can also occur. … The human NatA complex co-translationally acetylates N-termini that bear a small amino acid (A, S, T, C, and occasionally V and G).
Metabolism and Physiological Effects of N-Acetylhistidine
smpdb.ca/view/SMP0126711MetabolicIn addition to the NAT enzymes and protein-based acetylation, N-acetylation of free histidine can also occur. … The human NatA complex co-translationally acetylates N-termini that bear a small amino acid (A, S, T, C, and occasionally V and G).
Drugs: HistidineMetabolism and Physiological Effects of Beta-Alanine
smpdb.ca/view/SMP0126732MetabolicThe associated inhibition of GABA transaminase and displacement of GABA from CNS binding sites can also lead to GABAuria (high levels of GABA in the urine) and convulsions. … Cellular taurine depletion is known to reduce respiratory function and elevate mitochondrial superoxide generation, which damages mitochondria and increases oxidative stress.
Metabolism and Physiological Effects of Indolelactic Acid
smpdb.ca/view/SMP0126749MetabolicTryptophan is metabolized by two major pathways in humans, either through kynurenine or via a series of indoles, and some of its metabolites are known to be biologically active. … Indolelactic acid (CAS: 1821-52-9) is a tryptophan metabolite found in human plasma, serum, and urine.
Metabolism and Physiological Effects of 1-Methylhistidine
smpdb.ca/view/SMP0126760MetabolicOther proteins that are known to have 1MH modifications include myosin and myosin kinase. … SETD3-mediated histidine methylation appears to occur in all higher eukaryotes with actin, from plants to insects to vertebrates. Within cells, SETD3 is found in the cytoplasm and nucleus.
Metabolism and Physiological Effects of Vanillic Acid
smpdb.ca/view/SMP0126881MetabolicVanillin is toxic to the cells and hence it is subject to catabolism caused by the oxidative activity of this protein. This is undesired from the production point of view of this important compound. … Vanillic acid is a phenolic acid found in some forms of vanilla and many other plant extracts. It is a flavouring and scent agent that produces a pleasant, creamy odour.
Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
smpdb.ca/view/SMP0000320SignalingThe A2A receptor is also expressed in the brain, where it has important roles in the regulation of glutamate and dopamine release. … downstream effectors that lead to a specific cellular response.
Drugs: ATP · Adenosine · Magnesium cation · Zinc · Cyclic adenosine monophosphate · Pyrophosphoric acid