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Metabolism and Physiological Effects of 3-Deoxyglucosone
smpdb.ca/view/SMP0125516MetabolicIt normally is synthesized and accumulates with high serum glucose due to diabetes. 3-deoxyglucosone causes cell apoptosis and neurotoxicity. … An amino acid like arginine or lysine are combined with glucose to make a schiff base and water. The schiff base is unstable so it becomes the stable amadori product.
Metabolism and Physiological Effects of N-Acetylproline
smpdb.ca/view/SMP0126660MetabolicN-terminal acetylation of proteins is a widespread and highly conserved process in eukaryotes that is involved in protection and stability of proteins. … N-acetylproline in the body can cause kidney damage and contribute to tumorigenesis, L-proline can be obtained from the diet from foods that are high in protein such as meat, fish, and dairy.
Metabolism and Physiological Effects of N-Acetylvaline
smpdb.ca/view/SMP0126701MetabolicThe human NatA complex co-translationally acetylates N-termini that bear a small amino acid (A, S, T, C, and occasionally V and G). … N-terminal acetylation of proteins is a widespread and highly conserved process in eukaryotes that is involved in protection and stability of proteins.
Drugs: ValineMetabolism and Physiological Effects of N-Acetylmethionine
smpdb.ca/view/SMP0126707MetabolicThe human NatA complex co-translationally acetylates N-termini that bear a small amino acid (A, S, T, C, and occasionally V and G). … N-terminal acetylation of proteins is a widespread and highly conserved process in eukaryotes that is involved in protection and stability of proteins.
Metabolism and Physiological Effects of N-Acetylhistidine
smpdb.ca/view/SMP0126711MetabolicThe human NatA complex co-translationally acetylates N-termini that bear a small amino acid (A, S, T, C, and occasionally V and G). … N-terminal acetylation of proteins is a widespread and highly conserved process in eukaryotes that is involved in protection and stability of proteins.
Drugs: HistidineMetabolism and Physiological Effects of Beta-Alanine
smpdb.ca/view/SMP0126732MetabolicIt is a component of the naturally occurring peptides carnosine and anserine and also of pantothenic acid (vitamin B-5), which itself is a component of coenzyme A. … It is formed in vivo by the degradation of dihydrouracil and carnosine.
Metabolism and Physiological Effects of Indolelactic Acid
smpdb.ca/view/SMP0126749MetabolicIndolelactic acid (CAS: 1821-52-9) is a tryptophan metabolite found in human plasma, serum, and urine. … Tryptophan is metabolized by two major pathways in humans, either through kynurenine or via a series of indoles, and some of its metabolites are known to be biologically active.
Metabolism and Physiological Effects of 1-Methylhistidine
smpdb.ca/view/SMP0126760MetabolicWithin cells, SETD3 is found in the cytoplasm and nucleus. Other proteins that are known to have 1MH modifications include myosin and myosin kinase. … histidine-containing peptides (such as anserine and ophidine/balenine).
Metabolism and Physiological Effects of Vanillic Acid
smpdb.ca/view/SMP0126881MetabolicVanillic acid is a phenolic acid found in some forms of vanilla and many other plant extracts. It is a flavouring and scent agent that produces a pleasant, creamy odour. … Vanillic acid selectively and specifically inhibits 5'nucleotidase activity. Vanillic acid is a microbial metabolite found in Amycolatopsis, Delftia, and Pseudomonas.
Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
smpdb.ca/view/SMP0000320SignalingThe A2A receptor is also expressed in the brain, where it has important roles in the regulation of glutamate and dopamine release.
Drugs: ATP · Adenosine · Magnesium cation · Zinc · Cyclic adenosine monophosphate · Pyrophosphoric acid