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Intermediate conductance calcium-activated potassium channel protein 4
go.drugbank.com/bio_entities/BE0000415TargetHumansIntermediate conductance calcium-activated potassium channel that mediates the voltage-independent transmembrane transfer of potassium across the cell membrane through a constitutive interaction with calmodulin … Also presents an inwardly rectifying current, thus reducing its already small outward conductance of potassium ions, which is particularly the case when the membrane potential displays positive values,
Polypeptides: Intermediate conductance calcium-activated potassium channel protein 4Function: calcium-activated potassium channel activityPotassium voltage-gated channel subfamily A member 1
go.drugbank.com/bio_entities/BE0000781TargetHumansVoltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and the central nervous system, but also in the kidney (PubMed:19903818, PubMed … Response to toxins that are selective for KCNA1, respectively for KCNA2, suggests that heteromeric potassium channels composed of both KCNA1 and KCNA2 play a role in pacemaking and regulate the output
Polypeptides: Potassium voltage-gated channel subfamily A member 1Synonyms: Voltage-gated potassium channel HBK1, Voltage-gated potassium channel subunit Kv1.1Small conductance calcium-activated potassium channel protein 3
go.drugbank.com/bio_entities/BE0004427TargetHumansAlso presents an inwardly rectifying current, thus reducing its already small outward conductance of potassium ions, which is particularly the case when the membrane potential displays positive values, … Small conductance calcium-activated potassium channel that mediates the voltage-independent transmembrane transfer of potassium across the cell membrane through a constitutive interaction with calmodulin
Polypeptides: Small conductance calcium-activated potassium channel protein 3Potassium voltage-gated channel subfamily A member 7
go.drugbank.com/bio_entities/BE0004719TargetHumansMediates the voltage-dependent potassium ion permeability of excitable membranes. … Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with
Polypeptides: Potassium voltage-gated channel subfamily A member 7Synonyms: Voltage-gated potassium channel subunit Kv1.7Potassium voltage-gated channel subfamily B member 1
go.drugbank.com/bio_entities/BE0004721TargetHumansVoltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain, but also in the pancreas and cardiovascular system. … Channel properties are also modulated by cytoplasmic ancillary beta subunits such as AMIGO1, KCNE1, KCNE2 and KCNE3, slowing activation and inactivation rate of the delayed rectifier potassium channels
Polypeptides: Potassium voltage-gated channel subfamily B member 1Synonyms: Delayed rectifier potassium channel 1, Voltage-gated potassium channel subunit Kv2.1Potassium voltage-gated channel subfamily B member 2
go.drugbank.com/bio_entities/BE0004722TargetHumansVoltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and smooth muscle cells. … Contributes to the delayed-rectifier voltage-gated potassium current in cortical pyramidal neurons and smooth muscle cells
Polypeptides: Potassium voltage-gated channel subfamily B member 2Synonyms: Voltage-gated potassium channel subunit Kv2.2Potassium voltage-gated channel subfamily E member 1
go.drugbank.com/bio_entities/BE0000489TargetHumansAncillary protein that functions as a regulatory subunit of the voltage-gated potassium (Kv) channel complex composed of pore-forming and potassium-conducting alpha subunits and of regulatory beta subunits … KCNE1 beta subunit modulates the gating kinetics and enhances stability of the channel complex (PubMed:19219384, PubMed:20533308, PubMed:9230439).
Polypeptides: Potassium voltage-gated channel subfamily E member 1Synonyms: Minimal potassium channel, Delayed rectifier potassium channel subunit IsKPotassium voltage-gated channel subfamily KQT member 1
go.drugbank.com/bio_entities/BE0000672TargetHumansPore-forming subunit of the voltage-gated potassium (Kv) channel involved in the regulation of cardiomyocyte excitability and important in normal development and functions of myocardium, inner ear, stomach … Induces a voltage-dependent current by rapidly activating and slowly deactivating potassium-selective outward current (PubMed:10646604, PubMed:11101505, PubMed:25441029, PubMed:8900283, PubMed:9108097,
Polypeptides: Potassium voltage-gated channel subfamily KQT member 1Synonyms: Voltage-gated potassium channel subunit Kv7.1, IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1Potassium voltage-gated channel subfamily KQT member 2
go.drugbank.com/bio_entities/BE0000897TargetTransporterHumansThe native M-current has a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness … M-channel association with SLC5A3/SMIT1 alters channel ion selectivity, increasing Na(+) and Cs(+) permeation relative to K(+) (PubMed:28793216).
Polypeptides: Potassium voltage-gated channel subfamily KQT member 2Synonyms: Voltage-gated potassium channel subunit Kv7.2, Neuroblastoma-specific potassium channel subunit alpha KvLQT2G protein-activated inward rectifier potassium channel 2
go.drugbank.com/bio_entities/BE0001030TargetHumansThis potassium channel may be involved in the regulation of insulin secretion by glucose and/or neurotransmitters acting through G protein-coupled receptors … Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it.
Polypeptides: G protein-activated inward rectifier potassium channel 2Synonyms: Potassium channel, inwardly rectifying subfamily J member 6