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Displaying results 61 - 70 of 605 in total
  1. Target

    Trefoil factor 1

    go.drugbank.com/bio_entities/BE0008981
    TargetHumans

    Stabilizer of the mucous gel overlying the gastrointestinal mucosa that provides a physical barrier against various noxious agents. May inhibit the growth of calcium oxalate crystals in urine

    Polypeptides: Trefoil factor 1
  2. Target

    Complement factor H

    go.drugbank.com/bio_entities/BE0009053
    TargetHumans

    For example, interacts with CR3/ITGAM receptor and thereby mediates the adhesion of human neutrophils to different pathogens. … As a cofactor of the serine protease factor I, CFH also regulates proteolytic degradation of already-deposited C3b (PubMed:18252712, PubMed:23332154, PubMed:28671664).

    Polypeptides: Complement factor HSynonyms: H factor 1
  3. Target

    Splicing factor 1

    go.drugbank.com/bio_entities/BE0009118
    TargetHumans

    Necessary for the ATP-dependent first step of spliceosome assembly. Binds to the intron branch point sequence (BPS) 5'-UACUAAC-3' of the pre-mRNA. May act as transcription repressor

    Polypeptides: Splicing factor 1Synonyms: Transcription factor ZFM1
  4. Target

    Transcription factor Sp1

    go.drugbank.com/bio_entities/BE0010335
    TargetHumans

    Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. … Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses

    Polypeptides: Transcription factor Sp1Function: bHLH transcription factor binding
  5. Target

    Transcription factor RelB

    go.drugbank.com/bio_entities/BE0013795
    TargetHumans

    NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis … and apoptosis.

    Polypeptides: Transcription factor RelBFunction: DNA-binding transcription factor activity, RNA polymerase II-specific
  6. Target

    Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)

    go.drugbank.com/bio_entities/BE0000423
    TargetTransporterHumans

    Transports non-alpha-amino acids such as beta-alanine with low affinity, and has a higher affinity for dipolar and cationic amino acids such as leucine and lysine (PubMed:18599538). … Can also transport carnitine, butirylcarnitine and propionylcarnitine coupled to the transmembrane gradients of Na(+) and Cl(-) (PubMed:17855766)

    Polypeptides: Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)
  7. Target

    B- and T-lymphocyte attenuator

    go.drugbank.com/bio_entities/BE0010629
    TargetHumans

    Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:12796776, PubMed:14652006, PubMed:15568026, PubMed:18193050). … In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state.

    Polypeptides: B- and T-lymphocyte attenuatorSynonyms: B- and T-lymphocyte-associated protein
  8. Target

    Fibroblast growth factor 1

    go.drugbank.com/bio_entities/BE0000689
    TargetHumans

    Acts as a ligand for FGFR1 and integrins. … Its binding to integrin, subsequent ternary complex formation with integrin and FGFR1, and the recruitment of PTPN11 to the complex are essential for FGF1 signaling.

    Polypeptides: Fibroblast growth factor 1Synonyms: Acidic fibroblast growth factor, Endothelial cell growth factor
  9. Target

    Tissue factor pathway inhibitor

    go.drugbank.com/bio_entities/BE0000967
    TargetHumans

    Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. … It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma

    Polypeptides: Tissue factor pathway inhibitorSynonyms: Lipoprotein-associated coagulation inhibitor
  10. Target

    Platelet-activating factor acetylhydrolase

    go.drugbank.com/bio_entities/BE0002409
    TargetHumans

    Hydrolyzes and inactivates platelet-activating factor (PAF, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine), a potent pro-inflammatory signaling lipid that acts through PTAFR on various innate immune cells … Hydrolyzes oxidatively truncated phospholipids carrying an aldehyde group at omega position, preventing their accumulation in low-density lipoprotein (LDL) particles and uncontrolled pro-inflammatory effects

    Polypeptides: Platelet-activating factor acetylhydrolase