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Remifentanil Action Pathway
smpdb.ca/view/SMP0000416Drug actionand decrease in cAMP production. … Analgesia, anesthesia, and respiratory depression are a function of remifentanial’s action on these mu-type opioid receptors.
Enzymes: Sodium channel subunit beta-1, Sodium-dependent serotonin transporterTramadol Action Action Pathway
smpdb.ca/view/SMP0000671Drug actionTramadol is an analgesic drug consisting of two enantiomer forms (+)-Tramadol and (-)-Tramadol. … Although tramadol is structurally related to codeine and morphine, it’s affinity for the mu receptor compared to other opioids is significantly less.
Enzymes: Sodium channel subunit beta-1, Sodium-dependent serotonin transporterDiphenoxylate Action Pathway
smpdb.ca/view/SMP0000675Drug actionThe binding of diphenoxylate will eventually lead to reduced pain because of decreased nerve conduction and release of neurotransmitter. … Hyperpolarization of neuron is caused by inactivation of calcium channels and activation of potassium channels via facilitated by G-protein.
Enzymes: Sodium channel subunit beta-1, Sodium-dependent serotonin transporterLevomethadyl Acetate Action Action Pathway
smpdb.ca/view/SMP0000677Drug actionHowever, levomethadyl acetate is more active and more toxic than morphine. … The binding of levomethadyl acetate will eventually lead to reduced pain because of decreased nerve conduction and release of neurotransmitter.
Enzymes: Sodium channel subunit beta-1, Sodium-dependent serotonin transporter3-Methylthiofentanyl Action Pathway
smpdb.ca/view/SMP0000679Drug actionThe binding of methadyl acetate will eventually lead to reduced pain because of decreased nerve conduction and release of neurotransmitter. … Hyperpolarization of neuron is caused by inactivation of calcium channels and activation of potassium channels via facilitated by G-protein.
Enzymes: Sodium channel subunit beta-1, Sodium-dependent serotonin transporterDimethylthiambutene Action Pathway
smpdb.ca/view/SMP0000680Drug actionG(i) protein can also open potassium channels and close calcium channels to result in hyperpolarize on neuron. … Dimethylthiambutene (also known as Ohton or Aminobutene) is an opioid analgesic and substrate for mu-type opioid receptor which can be used for relieving pain.
Enzymes: Sodium channel subunit beta-1, Sodium-dependent serotonin transporterNaloxone Action Pathway
smpdb.ca/view/SMP0000688Drug actionIn recent study, naloxone shows that it can also bind to kappa and gamma-opioid receptors.
Enzymes: Sodium channel subunit beta-1, Sodium-dependent serotonin transporterHydromorphone Action Pathway
smpdb.ca/view/SMP0000410Drug actionThe binding of hydromorphone will eventually lead to reduced pain because of decreased nerve conduction and release of neurotransmitter. … Hyperpolarization of neuron is caused by inactivation of calcium channels and activation of potassium channels via facilitated by G-protein.
Enzymes: Sodium channel subunit beta-1, Sodium-dependent serotonin transporterHydrocodone Action Pathway
smpdb.ca/view/SMP0000411Drug actionThe binding of hydrocodone will eventually lead to reduced pain because of decreased nerve conduction and release of neurotransmitter. … Hyperpolarization of neuron is caused by inactivation of calcium channels and activation of potassium channels via facilitated by G-protein.
Enzymes: Sodium channel subunit beta-1, Sodium-dependent serotonin transporterAlfentanil Action Pathway
smpdb.ca/view/SMP0000413Drug actionThe binding of alfentanil will eventually lead to reduced pain because of decreased nerve conduction and release of neurotransmitter. … Hyperpolarization of neuron is caused by inactivation of calcium channels and activation of potassium channels via facilitated by G-protein.
Enzymes: Sodium channel subunit beta-1, Sodium-dependent serotonin transporter