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Displaying results 61 - 70 of 259 in total
  1. Target

    Sodium channel protein type 4 subunit alpha

    go.drugbank.com/bio_entities/BE0002083
    TargetTransporterHumans

    Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across … Pore-forming subunit of Nav1.4, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes.

    Polypeptides: Sodium channel protein type 4 subunit alphaSynonyms: Sodium channel protein type IV subunit alpha, Sodium channel protein skeletal muscle subunit alpha
  2. Target

    Sodium/potassium-transporting ATPase subunit beta-2

    go.drugbank.com/bio_entities/BE0005018
    TransporterTargetHumans

    This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane.

    Polypeptides: Sodium/potassium-transporting ATPase subunit beta-2Synonyms: Sodium/potassium-dependent ATPase subunit beta-2
  3. Target

    Sodium/potassium-transporting ATPase subunit alpha-1

    go.drugbank.com/bio_entities/BE0000732
    TargetEnzymeTransporterHumans

    Could also be part of an osmosensory signaling pathway that senses body-fluid sodium levels and controls salt intake behavior as well as voluntary water intake to regulate sodium homeostasis (By similarity … This process maintains essential Na(+) and K(+) gradients for membrane potential and cellular function.

    Polypeptides: Sodium/potassium-transporting ATPase subunit alpha-1Synonyms: Sodium pump subunit alpha-1
  4. Target

    ATP synthase subunit c, sodium ion specific

    go.drugbank.com/bio_entities/BE0001846
    TargetPropionigenium modestum

    F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane sodium channel, linked together by a central stalk and a peripheral … F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient.

    Polypeptides: ATP synthase subunit c, sodium ion specific
  5. Target

    Sodium channel protein type 8 subunit alpha

    go.drugbank.com/bio_entities/BE0002084
    TargetHumans

    Pore-forming subunit of a voltage-gated sodium channel complex assuming opened or closed conformations in response to the voltage difference across membranes and through which sodium ions selectively pass … Contributes to neuronal excitability by regulating action potential threshold and propagation (PubMed:24874546, PubMed:25239001, PubMed:25725044, PubMed:26900580, PubMed:29726066, PubMed:33245860, PubMed

    Polypeptides: Sodium channel protein type 8 subunit alphaSynonyms: Sodium channel protein type VIII subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.6
  6. Target

    Sodium/potassium-transporting ATPase subunit alpha-4

    go.drugbank.com/bio_entities/BE0005031
    TransporterHumans

    Plays an essential for sperm motility, capacitation, and male fertility by maintaining ionic gradients required for flagellar function and signaling (By similarity) … Transports 3 Na(+) ions out of the cell and 2 K(+) ions into the cell for each ATP hydrolyze (PubMed:16861705).

    Polypeptides: Sodium/potassium-transporting ATPase subunit alpha-4Synonyms: Sodium pump subunit alpha-4
  7. Target

    Sodium channel protein type 7 subunit alpha

    go.drugbank.com/bio_entities/BE0009590
    TargetHumans

    Sodium leak channel functioning as an osmosensor regulating sodium ion levels in various tissues and organs. … While most sodium channels are voltage-gated, SCN7A is not and lets sodium flow through membrane along its concentration gradient (PubMed:26537257, PubMed:35301303).

    Polypeptides: Sodium channel protein type 7 subunit alphaSynonyms: Atypical sodium channel Nav2.1, Sodium channel protein type VII subunit alpha
  8. Target

    Sodium channel protein type 1 subunit alpha

    go.drugbank.com/bio_entities/BE0000141
    TargetHumans

    Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across … Pore-forming subunit of Nav1.1, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes.

    Polypeptides: Sodium channel protein type 1 subunit alphaSynonyms: Sodium channel protein brain I subunit alpha, Sodium channel protein type I subunit alpha
  9. Target

    Sodium channel protein type 10 subunit alpha

    go.drugbank.com/bio_entities/BE0000177
    TargetHumans

    Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their … Tetrodotoxin-resistant channel that mediates the voltage-dependent sodium ion permeability of excitable membranes.

    Polypeptides: Sodium channel protein type 10 subunit alphaSynonyms: Peripheral nerve sodium channel 3, Sodium channel protein type X subunit alpha
  10. Target

    Sodium channel protein type 5 subunit alpha

    go.drugbank.com/bio_entities/BE0000197
    TargetHumans

    Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across … Nav1.5 is the predominant sodium channel expressed in myocardial cells and it is responsible for the initial upstroke of the action potential in cardiac myocytes, thereby initiating the heartbeat (PubMed

    Polypeptides: Sodium channel protein type 5 subunit alphaSynonyms: Sodium channel protein type V subunit alpha, Sodium channel protein cardiac muscle subunit alpha