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Hydroxycarboxylic acid receptor 2
go.drugbank.com/bio_entities/BE0000635TargetHumansActs as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated … Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis
Polypeptides: Hydroxycarboxylic acid receptor 2Synonyms: Niacin receptor 1, Nicotinic acid receptor5-hydroxytryptamine receptor 1D
go.drugbank.com/bio_entities/BE0000659TargetHumansG protein-coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:10452531, PubMed:1565658, PubMed:1652050, PubMed:33762731). … Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances (PubMed:10452531, PubMed:1565658, PubMed:1652050, PubMed:33762731
Polypeptides: 5-hydroxytryptamine receptor 1DSynonyms: Serotonin receptor 1D, Serotonin 1D alpha receptorRetinoic acid receptor alpha
go.drugbank.com/bio_entities/BE0000663TargetHumansReceptor for retinoic acid (PubMed:16417524, PubMed:19850744, PubMed:20215566, PubMed:21152046, PubMed:37478846).
Polypeptides: Retinoic acid receptor alphaSynonyms: Nuclear receptor subfamily 1 group B member 1Thyroid hormone receptor alpha
go.drugbank.com/bio_entities/BE0000687TargetHumansNuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine
Polypeptides: Thyroid hormone receptor alphaSynonyms: Nuclear receptor subfamily 1 group A member 1Cysteinyl leukotriene receptor 1
go.drugbank.com/bio_entities/BE0000705TargetHumansReceptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma.
Polypeptides: Cysteinyl leukotriene receptor 1Synonyms: LTD4 receptor, G protein-coupled receptor HG55Epidermal growth factor receptor
go.drugbank.com/bio_entities/BE0000767TargetEnzymeHumansActivates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules (PubMed:27153536). … Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling (PubMed:11602604).
Polypeptides: Epidermal growth factor receptorSynonyms: Receptor tyrosine-protein kinase erbB-1Metabotropic glutamate receptor 1
go.drugbank.com/bio_entities/BE0000824TargetHumansG protein-coupled receptor for glutamate.
Polypeptides: Metabotropic glutamate receptor 1Function: adenylate cyclase inhibiting G protein-coupled glutamate receptor activityMetabotropic glutamate receptor 4
go.drugbank.com/bio_entities/BE0000833TargetHumansG protein-coupled receptor for glutamate.
Polypeptides: Metabotropic glutamate receptor 4Function: adenylate cyclase inhibiting G protein-coupled glutamate receptor activityMetabotropic glutamate receptor 8
go.drugbank.com/bio_entities/BE0000835TargetHumansG protein-coupled receptor for glutamate.
Polypeptides: Metabotropic glutamate receptor 8Function: G protein-coupled receptor activityHepatocyte growth factor receptor
go.drugbank.com/bio_entities/BE0000915TargetHumansReceptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. … Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules.
Polypeptides: Hepatocyte growth factor receptorSynonyms: Proto-oncogene c-Met, Tyrosine-protein kinase Met