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Sphingosine 1-phosphate receptor 1
go.drugbank.com/bio_entities/BE0008652TargetHumansG protein-coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. … Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the
Polypeptides: Sphingosine 1-phosphate receptor 1Synonyms: S1P receptor 1, S1P receptor Edg-1G protein-coupled receptor 12
go.drugbank.com/bio_entities/BE0009153TargetHumansFunctions as a receptor with constitutive G(s)-mediated signaling activity that stimulates cyclic AMP (cAMP) production (PubMed:36593162). … Brain-specific G protein-coupled receptor involved in regulating diverse physiological processes including neurite outgrowth, meiotic arrest, and lipid and carbohydrate metabolism (By similarity).
Polypeptides: G protein-coupled receptor 12Function: G protein-coupled receptor activityTyrosine-protein kinase receptor TYRO3
go.drugbank.com/bio_entities/BE0009404TargetHumansReceptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6.
Polypeptides: Tyrosine-protein kinase receptor TYRO3Ephrin type-A receptor 1
go.drugbank.com/bio_entities/BE0009436TargetHumansThe signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. … Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells.
Polypeptides: Ephrin type-A receptor 1Synonyms: Tyrosine-protein kinase receptor EPH, Erythropoietin-producing hepatoma receptorEphrin type-A receptor 8
go.drugbank.com/bio_entities/BE0009440TargetHumansReceptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. … The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling.
Polypeptides: Ephrin type-A receptor 8Synonyms: Tyrosine-protein kinase receptor EEKEphrin type-B receptor 1
go.drugbank.com/bio_entities/BE0009441TargetHumansCognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3. … Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells.
Polypeptides: Ephrin type-B receptor 1Synonyms: Tyrosine-protein kinase receptor EPH-2NT-3 growth factor receptor
go.drugbank.com/bio_entities/BE0009501TargetHumansReceptor tyrosine kinase involved in nervous system and probably heart development.
Polypeptides: NT-3 growth factor receptorSynonyms: Neurotrophic tyrosine kinase receptor type 3Receptor for retinol uptake STRA6
go.drugbank.com/bio_entities/BE0009879TransporterHumansFunctions as a retinol transporter. Accepts all-trans retinol from the extracellular retinol-binding protein RBP4, facilitates retinol transport across the cell membrane, and then transfers retinol to the cytoplasmic retinol-binding prot...
Polypeptides: Receptor for retinol uptake STRA6Synonyms: Retinol-binding protein receptor STRA6Sphingosine 1-phosphate receptor 4
go.drugbank.com/bio_entities/BE0009882TargetHumansFunctions as a receptor for the lysosphingolipid sphingosine-1-phosphate (S1P). … G protein-coupled receptor highly expressed in immune cells, where it regulates immune response and cytokine production.
Polypeptides: Sphingosine 1-phosphate receptor 4Synonyms: S1P receptor 4, S1P receptor Edg-6C5a anaphylatoxin chemotactic receptor 1
go.drugbank.com/bio_entities/BE0010095TargetHumansLigand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed … Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a, stimulating chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (PubMed:10636859,
Polypeptides: C5a anaphylatoxin chemotactic receptor 1Synonyms: C5a anaphylatoxin chemotactic receptor