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NADH-ubiquinone oxidoreductase chain 2
go.drugbank.com/bio_entities/BE0000655TargetHumansCore subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed:16996290). Essential ...
Polypeptides: NADH-ubiquinone oxidoreductase chain 2Synonyms: NADH dehydrogenase subunit 2Acid-sensing ion channel 2
go.drugbank.com/bio_entities/BE0000678TargetHumansForms pH-gated trimeric sodium channels that act as postsynaptic excitatory sensors in the nervous system (PubMed:10842183, PubMed:23034652, PubMed:8626462, PubMed:8631835). Upon extracellular acidification, these channels generate rapid...
Polypeptides: Acid-sensing ion channel 2Fibroblast growth factor receptor 2
go.drugbank.com/bio_entities/BE0000748TargetHumansTyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic ...
Polypeptides: Fibroblast growth factor receptor 2Synonyms: FGFR-2Glutamate receptor ionotropic, kainate 2
go.drugbank.com/bio_entities/BE0000826TargetHumansIonotropic glutamate receptor that functions as a cation-permeable ligand-gated ion channel, gated by L-glutamate and the glutamatergic agonist kainic acid (PubMed:7536611, PubMed:8730589, PubMed:14511640). L-glutamate acts as an excitat...
Polypeptides: Glutamate receptor ionotropic, kainate 2Excitatory amino acid transporter 2
go.drugbank.com/bio_entities/BE0000884TargetTransporterHumansSodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:14506254, PubMed:15265858, PubMed:26690923, PubMed:7521911). Functions as a symporter that transp...
Polypeptides: Excitatory amino acid transporter 2Synonyms: Solute carrier family 1 member 2, Sodium-dependent glutamate/aspartate transporter 2Atrial natriuretic peptide receptor 2
go.drugbank.com/bio_entities/BE0000997TargetHumansReceptor for the C-type natriuretic peptide NPPC/CNP hormone. Has guanylate cyclase activity upon binding of its ligand. May play a role in the regulation of skeletal growth
Polypeptides: Atrial natriuretic peptide receptor 2Protein-glutamine gamma-glutamyltransferase 2
go.drugbank.com/bio_entities/BE0001035TargetEnzymeHumansCatalyzes serotonylation of 'Gln-5' of histone H3 (H3Q5ser) during serotonergic neuron differentiation, thereby facilitating transcription (PubMed:30867594). … Under physiological conditions, the protein cross-linking activity is inhibited by GTP; inhibition is relieved by Ca(2+) in response to various stresses (PubMed:18092889, PubMed:7592956, PubMed:7649299
Polypeptides: Protein-glutamine gamma-glutamyltransferase 2Synonyms: TGase-2, Transglutaminase-2Cyclopropane mycolic acid synthase 2
go.drugbank.com/bio_entities/BE0001211TargetMycobacterium tuberculosisCatalyzes the formation of trans cyclopropanated ketomycolate or methoxymycolate through the conversion of a double bond to a cyclopropane ring at the proximal position of an oxygenated mycolic acid via the transfer of a methylene group ...
Polypeptides: Cyclopropane mycolic acid synthase 2Synonyms: CMAS-2Metallo-beta-lactamase type 2
go.drugbank.com/bio_entities/BE0001212TargetEnzymeBacteroides fragilisConfers resistance to the different beta-lactams antibiotics (penicillin, cephalosporin and carbapenem) via the hydrolysis of the beta-lactam ring.
Polypeptides: Metallo-beta-lactamase type 22-dehydro-3-deoxyphosphooctonate aldolase
go.drugbank.com/bio_entities/BE0001253TargetAquifex aeolicus (strain VF5)Polypeptides: 2-dehydro-3-deoxyphosphooctonate aldolaseSynonyms: Phospho-2-dehydro-3-deoxyoctonate aldolase