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Alpha-2A adrenergic receptor
go.drugbank.com/bio_entities/BE0000289TargetHumansAlpha-2 adrenergic receptors are G protein-coupled receptors for catecholamines that activate the G(i/o) protein pathway, thereby promoting adenylyl cyclase inhibition, ERK1/2 stimulation, and voltage-gated calcium channels suppression (...
Polypeptides: Alpha-2A adrenergic receptorSynonyms: Alpha-2 adrenergic receptor subtype C10Melatonin receptor type 1B
go.drugbank.com/bio_entities/BE0000327TargetHumansHigh affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. … The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity
Polypeptides: Melatonin receptor type 1BSynonyms: Mel1b receptorALK tyrosine kinase receptor
go.drugbank.com/bio_entities/BE0000359TargetHumansNeuronal receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation … MDK-binding induces phosphorylation of the ALK target insulin receptor substrate (IRS1), activates mitogen-activated protein kinases (MAPKs) and PI3-kinase, resulting also in cell proliferation induction
Polypeptides: ALK tyrosine kinase receptorCholecystokinin receptor type A
go.drugbank.com/bio_entities/BE0000402TargetHumansReceptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. … This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system
Polypeptides: Cholecystokinin receptor type ASynonyms: CCK-A receptor, Cholecystokinin-1 receptorInterferon gamma receptor 2
go.drugbank.com/bio_entities/BE0000467TargetHumansRequired for signal transduction in contrast to other receptor subunit responsible for ligand binding (PubMed:7673114) … Associates with IFNGR1 to form a receptor for the cytokine interferon gamma (IFNG) (PubMed:7615558, PubMed:7673114, PubMed:8124716).
Polypeptides: Interferon gamma receptor 2Synonyms: IFN-gamma receptor 2, Interferon gamma receptor beta-chainAlpha-1A adrenergic receptor
go.drugbank.com/bio_entities/BE0000501TargetHumansAlpha-1 adrenergic receptors are G protein-coupled receptors for catecholamines that signal through the G(q) family of G proteins, including G(q) and G(11). Upon activation, they stimulate the phosphatidylinositol-calcium second messenge...
Polypeptides: Alpha-1A adrenergic receptorSynonyms: Alpha-1C adrenergic receptor, Alpha-adrenergic receptor 1cKappa-type opioid receptor
go.drugbank.com/bio_entities/BE0000632TargetHumansG protein-coupled opioid receptor that functions as a receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. … Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase.
Polypeptides: Kappa-type opioid receptorFunction: dynorphin receptor activityActivin receptor type-1B
go.drugbank.com/bio_entities/BE0000665TargetHumansActivin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor. ACVR1B also phosphorylates TDP2 … Transmembrane serine/threonine kinase activin type-1 receptor forming an activin receptor complex with activin receptor type-2 (ACVR2A or ACVR2B).
Polypeptides: Activin receptor type-1BSynonyms: Activin receptor type IB, Activin receptor-like kinase 4Alpha-1D adrenergic receptor
go.drugbank.com/bio_entities/BE0000715TargetHumansAlpha-1 adrenergic receptors are G protein-coupled receptors for catecholamines that signal through the G(q) family of G proteins, including G(q) and G(11). Upon activation, they stimulate the phosphatidylinositol-calcium second messenge...
Polypeptides: Alpha-1D adrenergic receptorSynonyms: Alpha-1A adrenergic receptor, Alpha-adrenergic receptor 1aMetabotropic glutamate receptor 2
go.drugbank.com/bio_entities/BE0000974TargetHumansDimeric G protein-coupled receptor which is activated by the excitatory neurotransmitter L-glutamate (PubMed:37286794). … Mechanistically, ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate
Polypeptides: Metabotropic glutamate receptor 2