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Displaying results 751 - 760 of 10000 in total
  1. Target

    Cytosol aminopeptidase

    go.drugbank.com/bio_entities/BE0003882
    TargetHumans

    For instance, in the presence of Mn(2+), it displays a specific Cys-Gly hydrolyzing activity of Cys-Gly-S-conjugates. … Involved in the metabolism of glutathione and in the degradation of glutathione S-conjugates, which may play a role in the control of the cell redox status

    Synonyms: Peptidase S, Cysteinylglycine-S-conjugate dipeptidase
  2. Target

    Complement C1s subcomponent

    go.drugbank.com/bio_entities/BE0001529
    TargetEnzymeHumans

    Component of the complement C1 complex, a multiprotein complex that initiates the classical pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the ...

    Synonyms: Complement component 1 subcomponent s
  3. Target

    Glyceraldehyde-3-phosphate dehydrogenase

    go.drugbank.com/bio_entities/BE0000542
    TargetHumans

    Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC (By similarity)

    Synonyms: Peptidyl-cysteine S-nitrosylase GAPDH
  4. Drug

    Chloroxylenol

    go.drugbank.com/drugs/DB11121
    Approved

    Chloroxylenol is on the World Health Organization's List of Essential Medicines. … It is found in antibacterial soaps, wound-cleansing applications, and household antiseptics.

    Synonyms: 2-chloro-5-hydroxy-m-xylene, 2-Chloro-m-xylenolMixtures: Cortane-B, Cortaine -B Aqueous
  5. Drug

    Paclitaxel

    go.drugbank.com/drugs/DB01229
    ApprovedInvestigationalVet approved

    Paclitaxel is a chemotherapeutic agent marketed under the brand name Taxol among others. … Used as a treatment for various cancers, paclitaxel is a mitotic inhibitor that was first isolated in 1971 from the bark of the Pacific yew tree which contains endophytic fungi that synthesize paclitaxel

    Synonyms: 5beta,20-Epoxy-1,2-alpha,4,7beta,10beta,13alpha-hexahydroxytax-11-en-9-one 4,10-diacetate 2-benzoate 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine, Taxol ACategories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP2C8 Substrates with a Narrow Therapeutic Index
  6. Target

    Adenosylhomocysteinase

    go.drugbank.com/bio_entities/BE0009225
    TargetPlasmodium falciparum (isolate 3D7)

    Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via

    Synonyms: S-adenosyl-L-homocysteine hydrolase
  7. Target

    Maleylacetoacetate isomerase

    go.drugbank.com/bio_entities/BE0000819
    TargetEnzymeHumans

    Bifunctional enzyme showing minimal glutathione-conjugating activity with ethacrynic acid and 7-chloro-4-nitrobenz-2-oxa-1,3-diazole and maleylacetoacetate isomerase activity. Also has low glutathione peroxidase activity with T-butyl and...

    Synonyms: Glutathione S-transferase zeta 1
  8. Target

    Adenosylhomocysteinase

    go.drugbank.com/bio_entities/BE0003776
    TargetMycobacterium tuberculosis

    May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

    Synonyms: S-adenosyl-L-homocysteine hydrolase
  9. Target

    Adenosine deaminase

    go.drugbank.com/bio_entities/BE0009226
    TargetPlasmodium falciparum (isolate 3D7)

    Catalyzes the hydrolytic deamination of adenosine to produce inosine (PubMed:19728741, PubMed:31002765). Unlike mammalian adenosine deaminases, also catalyzes the deamination of 5'-methylthioadenosine (MTA), a by-product of polyamine bio...

    Synonyms: S-methyl-5'-thioadenosine deaminase
  10. Drug

    Dimenhydrinate

    go.drugbank.com/drugs/DB00985
    ApprovedInvestigational

    [L32980,L32985,L32995] Dimenhydrinate is a combination of [Diphenhydramine] and [8-chlorotheophylline] in a salt form, with 53%-55.5% dried diphenhydramine, and 44%-47% died 8-chlorotheophylline. … [A233130] Dimenhydrinate, also known as B-dimethylaminoethyl benzohydrol ether 8-chlorotheophyllinate, is indicated to prevent nausea, vomiting, and dizziness caused by motion sickness.

    Synonyms: 8-chloro-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione - 2-(diphenylmethoxy)-N,N-dimethylethanamine (1:1), N,N-dimethyl-2-diphenylmethoxyethylamine 8-chlorotheophyllinateInternational brands: Vomex A