Chloroxylenol

Identification

Summary

Chloroxylenol is an antimicrobial used to treat cuts, bites, stings, abrasions, and used as an antiseptic hand cleaner.

Brand Names

Cortane-B

Generic Name

Chloroxylenol

DrugBank Accession Number

DB11121

Background

Chloroxylenol, or para-chloro-meta-xylenol (PCMX), is an antiseptic and disinfectant agent used for skin disinfection and surgical instruments. It is found in antibacterial soaps, wound-cleansing applications, and household antiseptics. The halophenol is shown to be most effective against Gram positive bacteria where it disrupts the cell wall due to its phenolic nature ¹. Chloroxylenol is on the World Health Organization's List of Essential Medicines.

Type

Small Molecule

Groups

Approved

Structure

Similar Structures

Weight: Average: 156.61
Monoisotopic: 156.0341926
Chemical Formula: C₈H₉ClO

Synonyms

2-chloro-5-hydroxy-1,3-dimethylbenzene
2-chloro-5-hydroxy-m-xylene
2-Chloro-m-xylenol
3,5-dimethyl-4-chlorophenol
4-chloro-1-hydroxy-3,5-dimethylbenzene
4-chloro-3,5-dimethylphenol
4-chloro-m-xylenol
chloro-xylenol
Chloroxylenol
cloroxilenol
p-chloro-3,5-xylenol
p-chloro-m-xylenol
parachlorometaxylenol
PCMX

Pharmacology

Indication

The predominant medical applications for which chloroxylenol is formally indicated for therapeutic use is as an application to the skin for use in cuts, bites, stings, abrasions, and for use as antiseptic hand cleaner ⁷.

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Associated Conditions

Skin Infections

Associated Therapies

Contraindications & Blackbox Warnings

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Pharmacodynamics

Chloroxylenol is a substituted phenol which has been widely used for many years as an ingredient of antiseptic and disinfectant products intended for external use ⁹. It is known to be bactericidal in low concentration to a wide range of Gram positive and Gram negative bacteria ⁹.

Mechanism of action

As a phenol antiseptic, it is believed that the hydroxyl -OH groups of the chloroxylenol molecule binds to certain proteins on the cell membrane of bacteria, and disrupts the membrane so as to allow the contents of the bacterial cell to leak out ¹. This allows chloroxylenol to enter the bacterial cell to bind further with more proteins and enzymes to disable the cell's functioning ¹. At particularly high concentrations of chloroxylenol, the protein and nucleic acid content of targeted bacterial cells become coagulated and cease to function, leading to rapid cell death ¹.

Absorption

No chloroxylenol was detected in the blood following the dermal administration of 2 g of p-chloroxylenol in an ethanol/olive oil vehicle in human subjects ³. After a dose of 5 g, only traces were found, after 8 g, 1 mg % (1 mg/dL) was found in the blood after 3 hours, and 4 mg % (4 mg/dL) after 24 hours ³. After a dose of 20 g, 4 mg % (4 mg/dL) was measured after half an hour, and 1 mg % (1 mg/dL) was present at 72 hours ³.

For antiseptic purposes, chloroxylenol is considered to be well-absorbed when applied to the skin ⁹.

Volume of distribution

The only data available regarding the volume of distribution of chloroxylenol is the mean Vss of 22.45 L determined after 200 mg intravenous single dose of chloroxylenol was administered to healthy mongrel dog subjects ^6,8.

Protein binding

One study determined the protein binding of chloroxylenol to be approximately 85.2% +/- 2.32% for serum albumin and 89.8% +/- 2.99% for whole human serum ².

Metabolism

Certain animal studies have shown that following dermal application of chloroxylenol, that the absorption was rapid with a Cmax = 1-2 hours, and that the administered substance was excreted via the kidney with almost complete elimination within 24 hours ⁷. The primary metabolites discovered in the excreted urine were glucuronides and sulfates ⁷. Some chloroxylenol monographs liken its pharmacokinetic profile to that of another antiseptic - triclosan - which is rapidly excreted in the urine also as a glucuronide metabolite, as observed in the human model ⁷.

Moreover, In one human subject administered 5 mg intragluteally, 14% was excreted with glucuronic acid and 17% with sulfuric acid at 3 days ⁴.

Any chloroxylenol absorbed into the body is likely extensively metabolized by the liver and rapidly excreted, mainly in the urine, as sulphate and glucuronide conjugates ⁹.

Hover over products below to view reaction partners

Chloroxylenol
- Glucuronic acid + Sulfuric acid

Route of elimination

The major route of excretion is likely in urine ^8,7, although some amounts may be found in bile and traces in exhaled air ⁶.

Half-life

One study estimated the mean terminal half-life and mean residence time after a 200 mg intravenous single dose of chloroxylenol in healthy mongrel dog subjects to be 1.7 and 1.69 hours, respectively ^6,8. Alternatively, some product monographs liken chloroxylenol to a similar liquid antiseptic, triclosan, whose calculated urinary excretion half-life in man is approximately 10 hours ⁷.

Clearance

The only data available regarding the clearance of chloroxylenol is the mean clearance rate of 13.76 L/hr following a 200 mg intravenous single dose of the substance into healthy mongrel dog subjects ^6,8.

Moreover, in another study, when 8 g of chloroxylenol was administered dermal on a human subject in an alcohol/glycerin vehicle, 11% was excreted in 48 hours ⁴.

Adverse Effects

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Toxicity

As chloroxylenol is predominantly employed as an active ingredient in various liquids or creams as cleaners, disinfectants, or antiseptics that are generally designed to be used topically, it is widely accepted that the use of such liquids - when used appropriately - is unlikely to present a sufficient volume that could be ingested to cause any medical problems ⁷. In the event of accidental eye contact, was with Luke warm water ⁷.

Chloroxylenol is known to have a low systemic toxicity, even at dosage levels many times higher that those likely to be absorbed during normal usage of the agent ⁹.

Pathways

Not Available

Pharmacogenomic Effects/ADRs

Not Available

Interactions

Drug Interactions

This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.

Drug	Interaction
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Tenofovir alafenamide	The serum concentration of Tenofovir alafenamide can be increased when it is combined with Chloroxylenol.

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Food Interactions

No interactions found.

Products

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Active Moieties

Name	Kind	UNII	CAS	InChI Key
Phenol	unknown	339NCG44TV	108-95-2	ISWSIDIOOBJBQZ-UHFFFAOYSA-N

Over the Counter Products

Name	Dosage	Strength	Route	Labeller	Marketing Start	Marketing End
1012 Antimicrobial	Soap	3 mg/1mL	Topical	ABC Compounding Co., Inc.	2013-05-01	Not applicable
986 Antiseptic Hand Soap-lot 0.5%	Lotion	0.5 %	Topical	Fuller Brush/Les Brosses Fuller	1994-12-31	1995-08-01
ACQUAINT Antibacterial Foam Handwash	Liquid	0.003 mg/1mL	Topical	GOJO Industries, Inc.	2004-09-09	Not applicable
ACQUAINT Antibacterial Foam Handwash	Liquid	.05 mg/1mL	Topical	GOJO Industries, Inc.	2019-06-15	Not applicable
Acute Kare Hand Sp.	Solution	0.5 g/100mL	Topical	Deb Canada	2017-03-01	2017-03-01
Acute-Kare Healthcare Personnel Handwash	Soap	1 g/100mL	Topical	SC Johnson Professional USA, Inc.	2018-02-01	Not applicable
Acute-Kare Healthcare Personnel Handwash	Soap	1 g/100mL	Topical	STERIS Corporation	1995-01-17	2019-03-19
adriana Gold	Liquid	0.3 g/100mL	Topical	Ostl, Inc.	2018-01-31	Not applicable
ADVANTAGE CHEMICAL Premium Antibacterial Foaming Hand So ap	Liquid	0.005 mg/1mL	Topical	Advantage Chemical, Inc.	2015-04-15	Not applicable
Aero CleansE2 Antibacterial	Liquid	2.1 mL/100mL	Topical	Deb USA, Inc.	2010-01-01	2018-04-01

Mixture Products

Name	Ingredients	Dosage	Route	Labeller	Marketing Start	Marketing End
4246 First Aid Kit	Chloroxylenol (0.1 g/100g) + Acetaminophen (325 mg/1) + Acetylsalicylic acid (325 mg/1) + Ammonia (0.045 g/0.3mL) + Benzocaine (5 g/100g) + Hydrocortisone acetate (1 g/100g) + Hydrocortisone acetate (1 g/100g) + Isopropyl alcohol (0.7 mL/1mL) + Lidocaine hydrochloride (24.64 mg/1mL) + Lidocaine hydrochloride (2 g/100g) + Povidone-iodine (10 mg/1mL) + Water (98.6 mL/100mL)	Kit	Ophthalmic; Oral; Respiratory (inhalation); Topical	Honeywell Safety Products USA, Inc	2018-10-18	Not applicable
4334 First Aid Kit	Chloroxylenol (0.1 g/100g) + Acetaminophen (500 mg/1) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Benzocaine (5 g/100g) + Ethanol (0.5 mL/1mL) + Isopropyl alcohol (0.7 mL/1mL) + Lidocaine hydrochloride (20 mg/1mL) + Lidocaine hydrochloride (2 g/100g) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g) + Povidone-iodine (10 mg/1mL)	Gel; Kit; Liquid; Ointment; Swab; Tablet	Oral; Topical	Honeywell Safety Products USA, Inc	2018-10-18	Not applicable
4357 First Aid Kit	Chloroxylenol (0.1 g/100g) + Bacitracin zinc (400 [iU]/1g) + Benzethonium chloride (0.2 g/100g) + Benzocaine (10 g/100g) + Benzocaine (5 g/100g) + Hydrocortisone acetate (1 g/100g) + Hydrocortisone acetate (1 g/100g) + Isopropyl alcohol (0.7 mL/1mL) + Lidocaine hydrochloride (2 g/100g) + Menthol (0.33 g/100g) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g) + Water (98.6 mL/100mL)	Cream; Gel; Kit; Liquid; Ointment; Spray; Swab	Ophthalmic; Topical	Honeywell Safety Products USA, Inc	2018-10-18	Not applicable
4358 First Aid Kit	Chloroxylenol (0.1 g/100g) + Ammonia (0.045 g/0.3mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Benzocaine (5 g/100g) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g) + Povidone-iodine (10 mg/1mL) + Water (98.6 mL/100mL)	Kit	Ophthalmic; Respiratory (inhalation); Topical	Honeywell Safety Products USA, Inc	2018-10-18	Not applicable
4367 First Aid Kit	Chloroxylenol (0.1 g/100g) + Ammonia (0.045 g/0.3mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Benzocaine (5 g/100g) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g) + Povidone-iodine (10 mg/1mL) + Water (98.6 mL/100mL)	Kit	Ophthalmic; Respiratory (inhalation); Topical	Honeywell Safety Products USA, Inc	2018-10-18	Not applicable
4379 First Aid Kit	Chloroxylenol (0.1 g/100g) + Acetaminophen (500 mg/1) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Benzocaine (5 g/100g) + Ethanol (0.5 mL/1mL) + Isopropyl alcohol (0.7 mL/1mL) + Lidocaine hydrochloride (2 g/100g) + Lidocaine hydrochloride (20 mg/1mL) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g) + Povidone-iodine (10 mg/1mL)	Gel; Kit; Liquid; Ointment; Swab; Tablet	Oral; Topical	Honeywell Safety Products USA, Inc	2018-10-18	Not applicable
Absorbine Jr Extra Strength Liniment	Chloroxylenol (0.5 %) + Levomenthol (4.0 %)	Liquid	Topical	Bridges Consumer Healthcare Llc	1992-12-31	Not applicable
Absorbine Jr Liniment	Chloroxylenol (0.5 %) + Levomenthol (1.25 %)	Solution	Topical	Bridges Consumer Healthcare Llc	1993-12-31	Not applicable
Absorbine Power Gel	Chloroxylenol (.5 %) + Levomenthol (4 %)	Gel	Topical	W.F. Young, Inc.	1993-12-31	Not applicable
Acne Aid Gel	Chloroxylenol (.375 %) + Octasulfur (2.5 %) + Resorcinol (1.25 %)	Gel	Topical	Stiefel Laboratories, Inc.	1966-12-31	1998-07-09

Unapproved/Other Products

Name	Ingredients	Dosage	Route	Labeller	Marketing Start	Marketing End
4246 First Aid Kit	Chloroxylenol (0.1 g/100g) + Acetaminophen (325 mg/1) + Acetylsalicylic acid (325 mg/1) + Ammonia (0.045 g/0.3mL) + Benzocaine (5 g/100g) + Hydrocortisone acetate (1 g/100g) + Hydrocortisone acetate (1 g/100g) + Isopropyl alcohol (0.7 mL/1mL) + Lidocaine hydrochloride (24.64 mg/1mL) + Lidocaine hydrochloride (2 g/100g) + Povidone-iodine (10 mg/1mL) + Water (98.6 mL/100mL)	Kit	Ophthalmic; Oral; Respiratory (inhalation); Topical	Honeywell Safety Products USA, Inc	2018-10-18	Not applicable
4334 First Aid Kit	Chloroxylenol (0.1 g/100g) + Acetaminophen (500 mg/1) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Benzocaine (5 g/100g) + Ethanol (0.5 mL/1mL) + Isopropyl alcohol (0.7 mL/1mL) + Lidocaine hydrochloride (20 mg/1mL) + Lidocaine hydrochloride (2 g/100g) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g) + Povidone-iodine (10 mg/1mL)	Gel; Kit; Liquid; Ointment; Swab; Tablet	Oral; Topical	Honeywell Safety Products USA, Inc	2018-10-18	Not applicable
4357 First Aid Kit	Chloroxylenol (0.1 g/100g) + Bacitracin zinc (400 [iU]/1g) + Benzethonium chloride (0.2 g/100g) + Benzocaine (10 g/100g) + Benzocaine (5 g/100g) + Hydrocortisone acetate (1 g/100g) + Hydrocortisone acetate (1 g/100g) + Isopropyl alcohol (0.7 mL/1mL) + Lidocaine hydrochloride (2 g/100g) + Menthol (0.33 g/100g) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g) + Water (98.6 mL/100mL)	Cream; Gel; Kit; Liquid; Ointment; Spray; Swab	Ophthalmic; Topical	Honeywell Safety Products USA, Inc	2018-10-18	Not applicable
4358 First Aid Kit	Chloroxylenol (0.1 g/100g) + Ammonia (0.045 g/0.3mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Benzocaine (5 g/100g) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g) + Povidone-iodine (10 mg/1mL) + Water (98.6 mL/100mL)	Kit	Ophthalmic; Respiratory (inhalation); Topical	Honeywell Safety Products USA, Inc	2018-10-18	Not applicable
4367 First Aid Kit	Chloroxylenol (0.1 g/100g) + Ammonia (0.045 g/0.3mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Benzocaine (5 g/100g) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g) + Povidone-iodine (10 mg/1mL) + Water (98.6 mL/100mL)	Kit	Ophthalmic; Respiratory (inhalation); Topical	Honeywell Safety Products USA, Inc	2018-10-18	Not applicable
4379 First Aid Kit	Chloroxylenol (0.1 g/100g) + Acetaminophen (500 mg/1) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Benzocaine (5 g/100g) + Ethanol (0.5 mL/1mL) + Isopropyl alcohol (0.7 mL/1mL) + Lidocaine hydrochloride (2 g/100g) + Lidocaine hydrochloride (20 mg/1mL) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g) + Povidone-iodine (10 mg/1mL)	Gel; Kit; Liquid; Ointment; Swab; Tablet	Oral; Topical	Honeywell Safety Products USA, Inc	2018-10-18	Not applicable
Antibacterial Foam	Chloroxylenol (5 mL/1000mL)	Soap	Topical	Sanihealth Products Corporation	2010-05-18	Not applicable
Champion Ultra Clean	Chloroxylenol (13 kg/100kg)	Liquid	Topical	Morgan Gallacher Inc. Dba Custom Chemical Formulators Inc.	2020-02-06	Not applicable
Champion Ultra Clean	Chloroxylenol (13 kg/100kg)	Liquid	Topical	Maintex	2020-02-06	Not applicable
Champion Ultra Clean Fragrance and Dye Free	Chloroxylenol (13 kg/100kg)	Liquid	Topical	Maintex	2020-02-06	Not applicable

Chemical Identifiers

UNII: 0F32U78V2Q
CAS number: 88-04-0
InChI Key: OSDLLIBGSJNGJE-UHFFFAOYSA-N
InChI: InChI=1S/C8H9ClO/c1-5-3-7(10)4-6(2)8(5)9/h3-4,10H,1-2H3
IUPAC Name: 4-chloro-3,5-dimethylphenol
SMILES: CC1=CC(O)=CC(C)=C1Cl

References

General References

McDonnell G, Russell AD: Antiseptics and disinfectants: activity, action, and resistance. Clin Microbiol Rev. 1999 Jan;12(1):147-79. [Article]
Judis J: Binding of selected phenol derivatives to human serum proteins. J Pharm Sci. 1982 Oct;71(10):1145-7. [Article]
ZONDEK B, FINKELSTEIN M: Blood concentration of P-chloro-xylenol in man following parenteral, percutaneous and rectal application. Proc Soc Exp Biol Med. 1946 Feb;61:200-2. [Article]
Zondek B, Shapiro B: Fate of halogenated phenols in the organism. Biochem J. 1943;37(5):592-5. [Article]
US EPA Reregistration Eligibility Decision (RED): Chloroxylenol [Link]
Exponent FDA Consumer Antispetics Rule: FDA Request for Data on Safety and Efficacy of Chloroxylenol [Link]
Electronic Medicines Compendium: Dettol (Chloroxylenol) Antiseptic Cream Monograph [Link]
NLM Toxnet: Chloroxylenol [Link]
Electronic Medicines Compendium: Dettol (chloroxylenol) Liquid Monograph [Link]

External Links

KEGG Drug: D03473
KEGG Compound: C14715
PubChem Compound: 2723
PubChem Substance: 347827904
ChemSpider: 21106017
BindingDB: 50238619
RxNav: 20877
ChEBI: 34393
ChEMBL: CHEMBL398440
ZINC: ZINC000000001132
Wikipedia: Chloroxylenol

MSDS

Download (47.9 KB)

Clinical Trials

Clinical Trials

Phase	Status	Purpose	Conditions	Count
4	Completed	Prevention	Skin Health	1
2	Completed	Treatment	Cystic Fibrosis (CF)	1
Not Available	Unknown Status	Prevention	Arthroscopic Rotator Cuff Repair / Cutibacterium Acnes	1

Pharmacoeconomics

Manufacturers

Not Available

Packagers

Not Available

Dosage Forms

Form	Route	Strength
Kit	Ophthalmic; Oral; Respiratory (inhalation); Topical
Cream; gel; kit; liquid; ointment; spray; swab	Ophthalmic; Topical
Kit	Ophthalmic; Respiratory (inhalation); Topical
Gel; kit; liquid; ointment; swab; tablet	Oral; Topical
Jelly	Topical
Soap	Topical	1 g/100mL
Liquid	Topical	2.1 mL/100mL
Liquid	Topical	1.49 %
Lotion	Topical	1.0 %
Soap	Topical	0.005 mL/1mL
Liquid	Topical	15 mg/1mL
Soap	Topical	15 g/1000mL
Solution	Topical	1.5 g/100mL
Gel	Topical	0.01 mg/1mL
Liquid	Topical	.3 mg/1mL
Liquid	Topical	0.5 %
Liquid	Topical	3.09 mg/1mL
Liquid	Topical	6.046 g/1L
Soap	Topical	40 g/1kg
Soap	Topical	.3 g/100g
Soap	Topical	5 mL/1000mL
Gel	Topical	1.0 % w/w
Soap	Topical	6.10 g/1L
Soap	Topical	4 g/1000mL
Liquid	Topical
Liquid	Topical	2.5 mg/1mL
Emulsion	Topical	0.5 % v/v
Gel	Topical	10 mg/1mL
Gel	Topical	0.3 g/100mL
Gel	Topical	4 mL/800mL
Lotion	Topical	3.6 mg/800mL
Soap	Topical	6.0 mg/1000mL
Liquid; soap	Topical	.6 %
Gel	Topical	0.75 g/100mL
Soap	Topical	0.45 g/100mL
Soap	Topical	10.11 g/1L
Lotion	Topical	0.6 %
Ointment	Topical	1.5 mg / g
Lotion	Topical	0.5 % w/w
Liquid	Topical	0.5 g/100mL
Soap	Topical	0.3 mg/100mL
Soap	Topical	25 g/100g
Ointment	Topical	8 mg / mL
Solution	Topical	30 mg/1mL
Solution	Topical	3.0 %
Solution	Topical	4.8 % w/v
Liquid	Topical	1.25 g/500mL
Cream	Topical	.25 %
Soap	Cutaneous	0.1 g/100g
Soap	Topical	0.282 mg/100mL
Liquid	Cutaneous; Topical	0.2 g/100g
Liquid	Topical	13 kg/100kg
Liquid	Topical	0.3 mg/1mL
Soap	Topical	0.10 g/100mL
Soap	Topical	0.1 g/100mL
Soap	Topical	15 g/1L
Liquid	Topical	3.0 mg/1mL
Solution	Topical	0.6 mg/100mL
Soap	Topical	10.1 mg/1mL
Soap	Topical	5 mg/0.001L
Liquid	Topical	0.507 g/100mL
Soap	Topical	5 mg/1mL
Liquid	Topical	0.75 mg/100mL
Liquid	Topical	7.5 mg/1mL
Soap	Topical	0.003 g/1mL
Liquid	Topical	3 kg/100kg
Liquid	Topical	5 %
Lotion	Topical
Liquid	Topical	0.305 g/100mL
Liquid	Topical	0.00375 mg/1mL
Kit; shampoo; soap	Topical
Liquid	Topical	5 mg/100mL
Soap	Topical	0.5 g/100mL
Shampoo	Topical
Liquid	Topical	4 mg/1mL
Lotion; soap	Topical	.5 %
Liquid	Topical	0.95 g/100mL
Soap	Topical	0.002 g/1mL
Liquid	Topical	.6 %
Solution	Topical	4.8 %
Liquid	Topical	10 %
Liquid
Liquid	Cutaneous	4.8 g/15mL
Solution	Topical	4.8 g/100mL
Solution	Topical	0.6 mL/100mL
Liquid	Topical	1 g/2L
Liquid	Topical	0.22 g/100mL
Cloth	Topical	0.2 g/100mL
Liquid	Topical	0.15 g/100mL
Sponge	Topical	3 %
Liquid	Topical	3 g/1L
Liquid	Topical	1.1 %
Solution	Topical	9 mg/1mL
Solution	Topical	1.0 mg/100mL
Solution	Topical	100 mg/1mL
Solution	Topical	5.20 mg/1mL
Solution	Topical	0.8 mg/100mL
Lotion	Topical	0.25 %
Solution	Topical	8 mg/1mL
Lotion; soap	Topical	0.8 %
Liquid	Topical	15.75 g/1000mL
Gel	Topical	2.5 mg/0.001L
Solution	Topical	2.5 mg/1mL
Soap	Topical	2.5 g/1000mL
Solution	Topical	0.50 %
Cream	Topical
Solution	Cutaneous
Soap	Topical	2 g/100L
Solution	Topical	10 mg/1mL
Soap	Topical	4.5 mg/1mL
Aerosol, foam	Topical
Liquid	Topical	0.015 g/100mL
Lotion	Topical	.5 %
Soap	Topical	2.5 mg/0.001L
Gel	Topical	3 mg/1mL
Liquid	Topical	0.01 mg/1mL
Liquid	Topical	.05 mg/1mL
Solution	Topical	0.3 g/100mL
Liquid	Topical	0.50 %
Cream
Soap	Topical	2.5 mg/1mL
Soap	Topical	0.6 g/100mL
Liquid	Topical	0.663 g/221mL
Liquid	Topical	0.5 g/100g
Soap	Topical	3 mg/1mL
Liquid	Topical	3.5 g/100mL
Liquid	Topical	0.003 mg/1mL
Liquid	Topical	0.50 g/100mL
Liquid	Topical	1.50 g/100mL
Lotion	Topical	10.22 g/1000mL
Solution / drops	Auricular (otic)
Gel	Topical	0.5 % w/w
Liquid	Topical; Vaginal
Liquid	Topical	3 mg/0.001L
Gel	Topical	5 mg/1mL
Soap	Topical	3 g/1000mL
Soap	Topical	3 mg/1g
Soap	Topical	0.75 g/100mL
Solution	Topical	1.75 % w/w
Solution	Topical	17.5 g/1L
Solution	Topical	0.0175 L/1L
Solution	Topical	0.0175 g/1mL
Aerosol, foam	Topical	0.005 g/1mL
Liquid	Topical	10.22 g/1000mL
Gel	Topical	0.05 g/59g
Solution	Topical	0.5 mg/100mL
Solution	Topical	4.8 %w/v
Liquid	Topical	5 mg/1mL
Gel	Topical	0.95 g/1g
Liquid	Topical	6 mg/1mL
Soap	Topical	0.95 g/100mL
Solution	Topical	6.12 mg/1mL
Cloth	Topical
Swab	Topical
Liquid	Topical	0.30 g/100g
Liquid	Topical	0.3 %
Solution	Topical
Gel	Topical	0.015 g/100mL
Gel	Topical
Lotion	Topical	.25 %
Liquid	Topical	.5 %
Liquid	Auricular (otic)
Cloth	Topical	0.5 %
Soap	Topical	2.5 mg/1g
Gel	Topical	2.5 mg/1mL
Soap	Topical	25 g/1000mL
Sponge	Topical	33 mg/1mL
Sponge	Topical	40 mg/1mL
Solution	Topical	3.3 mg/100mL
Liquid	Topical	0.6 g/100g
Soap	Topical	0.005 g/1mL
Soap	Topical	0.1 g/100g
Liquid	Topical	0.3 g/100mL
Liquid	Topical	0.6657 mg/221.8mL
Liquid	Topical	1.5 %
Solution	Topical	0.6 % w/w
Liquid	Topical	3 mg/1mL
Solution	Topical	0.525 % w/w
Liquid	Topical	0.5 mg/100mL
Liquid	Topical	.25 %
Liquid	Topical	0.30 kg/100kg
Lotion	Topical	.6 %
Solution	Topical	6 mg/1mL
Soap	Topical	0.3 g/100mL
Liquid	Topical	0.5 mL/100mL
Solution	Topical	5 mg/1mL
Solution	Topical	5.2 mg/1mL
Solution	Topical	5.25 mg/1mL
Lotion	Topical	.3 %
Liquid	Topical	0.005 mg/1mL
Solution	Topical	0.005 mg/1mL
Soap	Topical	0.2 g/100mL
Soap	Topical	6 mg/1mL
Liquid	Topical	2.949 g/100mL
Liquid	Topical	3 % w/v
Liquid	Topical	3 mL/100mL
Liquid	Topical	0.8 mL/100mL
Lotion	Topical	0.08 mg/100mL
Ointment	Topical
Gel	Topical	1 %
Lotion	Topical	3.0 g/100mL
Soap	Topical	30 mg/10mL
Liquid	Topical	.7 %
Soap	Topical	5 g/1000mL
Liquid	Topical	0.3 mg/100mL
Liquid	Topical	3000 mg/1L
Gel	Topical	0.5 g/100g
Gel	Topical	0.3 g/100g
Soap	Topical	0.1 g/1L
Soap	Topical	4 mg/1mL
Liquid	Topical	0.1 g/100mL
Liquid	Topical	0.0060 mg/1mL
Liquid	Topical	0.0060 g/1mL
Solution	Topical	0.5 % w/w
Solution	Topical	0.5 g/100mL
Solution	Topical	1.75 %
Solution	Topical	1.25 g/100mL
Solution	Topical	1.25 %
Liquid	Topical	1.75 %
Solution	Topical	33 mg/1mL
Solution	Topical	40 mg/1mL
Solution	Topical	3.3 %
Solution	Topical	4 mg/100mL
Lotion	Topical	0.5 %
Aerosol, foam	Topical	.5 mL/100mL
Lotion	Topical	0.3 %
Liquid	Topical	0.6 g/100mL
Liquid	Topical	5 g/1L
Aerosol, foam	Topical	5 mg/1mL
Soap	Topical	0.33 mg/1000mL
Liquid	Topical	1.0 %
Aerosol	Topical	.1 %
Soap	Topical	10 mg/1mL
Solution	Topical	3.82 g/100mL
Liquid	Topical	0.3 mL/100mL
Liquid	Topical	1 g/100mL
Liquid	Topical	1 % w/w
Solution	Topical	10 g/1L
Solution	Topical	1 g/100mL
Lotion	Topical	0.51 %
Soap	Topical	0.001 mg/100mL
Liquid	Topical	1 %
Liquid	Topical	12.604 g/100mL
Liquid	Topical	10 g/1000mL
Liquid	Topical	10 mg/1mL
Solution	Topical	0.3 mg/1mL
Soap	Topical	3 %
Liquid	Topical	3 %
Soap	Topical	0.03 g/100mL
Solution	Topical	0.5 %
Gel	Topical	.25 %
Liquid	Topical	2 %
Gel	Topical	2 mg/1mL
Liquid	Topical	0.05 g/100mL
Soap	Topical	2.75 g/100mL
Solution	Topical	2.75 % w/w
Liquid	Topical	2.75 g/100mL
Liquid	Topical	0.3 kg/100kg
Lotion	Topical	1 %
Soap	Topical	3.75 mg/1mL
Soap	Topical	0.75 g/100g
Liquid	Topical	50 g/1L
Soap	Topical	3.6 g/1mL
Liquid	Topical	3.09 g/1mL
Liquid	Topical	3.06 mg/1mL
Liquid	Topical	1 g/1L
Gel	Topical	0.52 g/100mL
Solution	Topical	0.52 %
Gel	Topical	0.5 %
Cloth	Topical	0.5 g/100g
Liquid	Topical	0.6 %
Liquid	Topical	0.65 %
Solution	Topical	0.5 % v/v
Solution	Topical	1.2 g/240mL
Solution	Topical
Soap	Topical	2.5 g/1L
Soap	Topical	1 g/1L
Soap	Topical	1 g/100g
Soap	Topical	7.5 mg/1mL
Soap	Topical	5.0 mg/1mL
Liquid	Topical	2081980 mg/208198mL
Soap	Topical	.5 %
Soap	Topical
Liquid	Topical	3 g/100mL
Liquid	Topical	0.4 g/100mL
Liquid	Topical	0.04 g/10L
Liquid	Topical	0.3 g/10mL
Liquid; shampoo	Topical

Prices

Not Available

Patents

Not Available

Properties

State

Liquid

Experimental Properties

Property	Value	Source
melting point (°C)	112-116 degrees Celsius	MSDS
boiling point (°C)	246 degrees Celsius	MSDS
water solubility	0.03 g/100ml at 15 degrees Celsius, 0.5 g/100ml at 100 degrees Celsius	MSDS

Predicted Properties

Property	Value	Source
Water Solubility	0.855 mg/mL	ALOGPS
logP	3.14	ALOGPS
logP	3.3	Chemaxon
logS	-2.3	ALOGPS
pKa (Strongest Acidic)	9.21	Chemaxon
pKa (Strongest Basic)	-6.3	Chemaxon
Physiological Charge	0	Chemaxon
Hydrogen Acceptor Count	1	Chemaxon
Hydrogen Donor Count	1	Chemaxon
Polar Surface Area	20.23 Å²	Chemaxon
Rotatable Bond Count	0	Chemaxon
Refractivity	42.93 m³·mol^-1	Chemaxon
Polarizability	16.04 Å³	Chemaxon
Number of Rings	1	Chemaxon
Bioavailability	1	Chemaxon
Rule of Five	Yes	Chemaxon
Ghose Filter	No	Chemaxon
Veber's Rule	Yes	Chemaxon
MDDR-like Rule	No	Chemaxon

Predicted ADMET Features

Not Available

Spectra

Mass Spec (NIST)

Not Available

Spectra

Spectrum	Spectrum Type	Splash Key
Mass Spectrum (Electron Ionization)	MS	splash10-05fu-9500000000-8bba3165beb98d883986
Predicted MS/MS Spectrum - 10V, Positive (Annotated)	Predicted LC-MS/MS	Not Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)	Predicted LC-MS/MS	Not Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)	Predicted LC-MS/MS	Not Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)	Predicted LC-MS/MS	Not Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)	Predicted LC-MS/MS	Not Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)	Predicted LC-MS/MS	Not Available
1H NMR Spectrum	1D NMR	Not Applicable
13C NMR Spectrum	1D NMR	Not Applicable

Drug created at December 03, 2015 16:51 / Updated at November 28, 2023 22:14

Chloroxylenol

Identification

Structure for Chloroxylenol (DB11121)

Pharmacology

Interactions

Products

Categories

Chemical Identifiers

References

Clinical Trials

Pharmacoeconomics

Properties

Spectra