Chloroxylenol
Identification
- Summary
Chloroxylenol is an antimicrobial used to treat cuts, bites, stings, abrasions, and used as an antiseptic hand cleaner.
- Brand Names
- Cortane-B
- Generic Name
- Chloroxylenol
- DrugBank Accession Number
- DB11121
- Background
Chloroxylenol, or para-chloro-meta-xylenol (PCMX), is an antiseptic and disinfectant agent used for skin disinfection and surgical instruments. It is found in antibacterial soaps, wound-cleansing applications, and household antiseptics. The halophenol is shown to be most effective against Gram positive bacteria where it disrupts the cell wall due to its phenolic nature 1. Chloroxylenol is on the World Health Organization's List of Essential Medicines.
- Type
- Small Molecule
- Groups
- Approved
- Structure
- Weight
- Average: 156.61
Monoisotopic: 156.0341926 - Chemical Formula
- C8H9ClO
- Synonyms
- 2-chloro-5-hydroxy-1,3-dimethylbenzene
- 2-chloro-5-hydroxy-m-xylene
- 2-Chloro-m-xylenol
- 3,5-dimethyl-4-chlorophenol
- 4-chloro-1-hydroxy-3,5-dimethylbenzene
- 4-chloro-3,5-dimethylphenol
- 4-chloro-m-xylenol
- chloro-xylenol
- Chloroxylenol
- cloroxilenol
- p-chloro-3,5-xylenol
- p-chloro-m-xylenol
- parachlorometaxylenol
- PCMX
Pharmacology
- Indication
The predominant medical applications for which chloroxylenol is formally indicated for therapeutic use is as an application to the skin for use in cuts, bites, stings, abrasions, and for use as antiseptic hand cleaner 7.
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- Associated Therapies
- Contraindications & Blackbox Warnings
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- Pharmacodynamics
Chloroxylenol is a substituted phenol which has been widely used for many years as an ingredient of antiseptic and disinfectant products intended for external use 9. It is known to be bactericidal in low concentration to a wide range of Gram positive and Gram negative bacteria 9.
- Mechanism of action
As a phenol antiseptic, it is believed that the hydroxyl -OH groups of the chloroxylenol molecule binds to certain proteins on the cell membrane of bacteria, and disrupts the membrane so as to allow the contents of the bacterial cell to leak out 1. This allows chloroxylenol to enter the bacterial cell to bind further with more proteins and enzymes to disable the cell's functioning 1. At particularly high concentrations of chloroxylenol, the protein and nucleic acid content of targeted bacterial cells become coagulated and cease to function, leading to rapid cell death 1.
- Absorption
No chloroxylenol was detected in the blood following the dermal administration of 2 g of p-chloroxylenol in an ethanol/olive oil vehicle in human subjects 3. After a dose of 5 g, only traces were found, after 8 g, 1 mg % (1 mg/dL) was found in the blood after 3 hours, and 4 mg % (4 mg/dL) after 24 hours 3. After a dose of 20 g, 4 mg % (4 mg/dL) was measured after half an hour, and 1 mg % (1 mg/dL) was present at 72 hours 3.
For antiseptic purposes, chloroxylenol is considered to be well-absorbed when applied to the skin 9.
- Volume of distribution
The only data available regarding the volume of distribution of chloroxylenol is the mean Vss of 22.45 L determined after 200 mg intravenous single dose of chloroxylenol was administered to healthy mongrel dog subjects 6,8.
- Protein binding
One study determined the protein binding of chloroxylenol to be approximately 85.2% +/- 2.32% for serum albumin and 89.8% +/- 2.99% for whole human serum 2.
- Metabolism
Certain animal studies have shown that following dermal application of chloroxylenol, that the absorption was rapid with a Cmax = 1-2 hours, and that the administered substance was excreted via the kidney with almost complete elimination within 24 hours 7. The primary metabolites discovered in the excreted urine were glucuronides and sulfates 7. Some chloroxylenol monographs liken its pharmacokinetic profile to that of another antiseptic - triclosan - which is rapidly excreted in the urine also as a glucuronide metabolite, as observed in the human model 7.
Moreover, In one human subject administered 5 mg intragluteally, 14% was excreted with glucuronic acid and 17% with sulfuric acid at 3 days 4.
Any chloroxylenol absorbed into the body is likely extensively metabolized by the liver and rapidly excreted, mainly in the urine, as sulphate and glucuronide conjugates 9.
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- Route of elimination
The major route of excretion is likely in urine 8,7, although some amounts may be found in bile and traces in exhaled air 6.
- Half-life
One study estimated the mean terminal half-life and mean residence time after a 200 mg intravenous single dose of chloroxylenol in healthy mongrel dog subjects to be 1.7 and 1.69 hours, respectively 6,8. Alternatively, some product monographs liken chloroxylenol to a similar liquid antiseptic, triclosan, whose calculated urinary excretion half-life in man is approximately 10 hours 7.
- Clearance
The only data available regarding the clearance of chloroxylenol is the mean clearance rate of 13.76 L/hr following a 200 mg intravenous single dose of the substance into healthy mongrel dog subjects 6,8.
Moreover, in another study, when 8 g of chloroxylenol was administered dermal on a human subject in an alcohol/glycerin vehicle, 11% was excreted in 48 hours 4.
- Adverse Effects
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- Toxicity
As chloroxylenol is predominantly employed as an active ingredient in various liquids or creams as cleaners, disinfectants, or antiseptics that are generally designed to be used topically, it is widely accepted that the use of such liquids - when used appropriately - is unlikely to present a sufficient volume that could be ingested to cause any medical problems 7. In the event of accidental eye contact, was with Luke warm water 7.
Chloroxylenol is known to have a low systemic toxicity, even at dosage levels many times higher that those likely to be absorbed during normal usage of the agent 9.
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
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interactions in your softwareTenofovir alafenamide The serum concentration of Tenofovir alafenamide can be increased when it is combined with Chloroxylenol. Identify potential medication risksEasily compare up to 40 drugs with our drug interaction checker.Get severity rating, description, and management advice.Learn more - Food Interactions
- No interactions found.
Products
- Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.
- Active Moieties
Name Kind UNII CAS InChI Key Phenol unknown 339NCG44TV 108-95-2 ISWSIDIOOBJBQZ-UHFFFAOYSA-N - Over the Counter Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image 1012 Antimicrobial Soap 3 mg/1mL Topical ABC Compounding Co., Inc. 2013-05-01 Not applicable US 986 Antiseptic Hand Soap-lot 0.5% Lotion 0.5 % Topical Fuller Brush/Les Brosses Fuller 1994-12-31 1995-08-01 Canada ACQUAINT Antibacterial Foam Handwash Liquid 0.003 mg/1mL Topical GOJO Industries, Inc. 2004-09-09 Not applicable US ACQUAINT Antibacterial Foam Handwash Liquid .05 mg/1mL Topical GOJO Industries, Inc. 2019-06-15 Not applicable US Acute Kare Hand Sp. Solution 0.5 g/100mL Topical Deb Canada 2017-03-01 2017-03-01 US Acute-Kare Healthcare Personnel Handwash Soap 1 g/100mL Topical SC Johnson Professional USA, Inc. 2018-02-01 Not applicable US Acute-Kare Healthcare Personnel Handwash Soap 1 g/100mL Topical STERIS Corporation 1995-01-17 2019-03-19 US adriana Gold Liquid 0.3 g/100mL Topical Ostl, Inc. 2018-01-31 Not applicable US ADVANTAGE CHEMICAL Premium Antibacterial Foaming Hand So ap Liquid 0.005 mg/1mL Topical Advantage Chemical, Inc. 2015-04-15 Not applicable US Aero CleansE2 Antibacterial Liquid 2.1 mL/100mL Topical Deb USA, Inc. 2010-01-01 2018-04-01 US - Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image 4246 First Aid Kit Chloroxylenol (0.1 g/100g) + Acetaminophen (325 mg/1) + Acetylsalicylic acid (325 mg/1) + Ammonia (0.045 g/0.3mL) + Benzocaine (5 g/100g) + Hydrocortisone acetate (1 g/100g) + Hydrocortisone acetate (1 g/100g) + Isopropyl alcohol (0.7 mL/1mL) + Lidocaine hydrochloride (24.64 mg/1mL) + Lidocaine hydrochloride (2 g/100g) + Povidone-iodine (10 mg/1mL) + Water (98.6 mL/100mL) Kit Ophthalmic; Oral; Respiratory (inhalation); Topical Honeywell Safety Products USA, Inc 2018-10-18 Not applicable US 4334 First Aid Kit Chloroxylenol (0.1 g/100g) + Acetaminophen (500 mg/1) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Benzocaine (5 g/100g) + Ethanol (0.5 mL/1mL) + Isopropyl alcohol (0.7 mL/1mL) + Lidocaine hydrochloride (20 mg/1mL) + Lidocaine hydrochloride (2 g/100g) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g) + Povidone-iodine (10 mg/1mL) Gel; Kit; Liquid; Ointment; Swab; Tablet Oral; Topical Honeywell Safety Products USA, Inc 2018-10-18 Not applicable US 4357 First Aid Kit Chloroxylenol (0.1 g/100g) + Bacitracin zinc (400 [iU]/1g) + Benzethonium chloride (0.2 g/100g) + Benzocaine (10 g/100g) + Benzocaine (5 g/100g) + Hydrocortisone acetate (1 g/100g) + Hydrocortisone acetate (1 g/100g) + Isopropyl alcohol (0.7 mL/1mL) + Lidocaine hydrochloride (2 g/100g) + Menthol (0.33 g/100g) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g) + Water (98.6 mL/100mL) Cream; Gel; Kit; Liquid; Ointment; Spray; Swab Ophthalmic; Topical Honeywell Safety Products USA, Inc 2018-10-18 Not applicable US 4358 First Aid Kit Chloroxylenol (0.1 g/100g) + Ammonia (0.045 g/0.3mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Benzocaine (5 g/100g) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g) + Povidone-iodine (10 mg/1mL) + Water (98.6 mL/100mL) Kit Ophthalmic; Respiratory (inhalation); Topical Honeywell Safety Products USA, Inc 2018-10-18 Not applicable US 4367 First Aid Kit Chloroxylenol (0.1 g/100g) + Ammonia (0.045 g/0.3mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Benzocaine (5 g/100g) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g) + Povidone-iodine (10 mg/1mL) + Water (98.6 mL/100mL) Kit Ophthalmic; Respiratory (inhalation); Topical Honeywell Safety Products USA, Inc 2018-10-18 Not applicable US 4379 First Aid Kit Chloroxylenol (0.1 g/100g) + Acetaminophen (500 mg/1) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Benzocaine (5 g/100g) + Ethanol (0.5 mL/1mL) + Isopropyl alcohol (0.7 mL/1mL) + Lidocaine hydrochloride (2 g/100g) + Lidocaine hydrochloride (20 mg/1mL) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g) + Povidone-iodine (10 mg/1mL) Gel; Kit; Liquid; Ointment; Swab; Tablet Oral; Topical Honeywell Safety Products USA, Inc 2018-10-18 Not applicable US Absorbine Jr Extra Strength Liniment Chloroxylenol (0.5 %) + Levomenthol (4.0 %) Liquid Topical Bridges Consumer Healthcare Llc 1992-12-31 Not applicable Canada Absorbine Jr Liniment Chloroxylenol (0.5 %) + Levomenthol (1.25 %) Solution Topical Bridges Consumer Healthcare Llc 1993-12-31 Not applicable Canada Absorbine Power Gel Chloroxylenol (.5 %) + Levomenthol (4 %) Gel Topical W.F. Young, Inc. 1993-12-31 Not applicable Canada Acne Aid Gel Chloroxylenol (.375 %) + Octasulfur (2.5 %) + Resorcinol (1.25 %) Gel Topical Stiefel Laboratories, Inc. 1966-12-31 1998-07-09 Canada - Unapproved/Other Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image 4246 First Aid Kit Chloroxylenol (0.1 g/100g) + Acetaminophen (325 mg/1) + Acetylsalicylic acid (325 mg/1) + Ammonia (0.045 g/0.3mL) + Benzocaine (5 g/100g) + Hydrocortisone acetate (1 g/100g) + Hydrocortisone acetate (1 g/100g) + Isopropyl alcohol (0.7 mL/1mL) + Lidocaine hydrochloride (24.64 mg/1mL) + Lidocaine hydrochloride (2 g/100g) + Povidone-iodine (10 mg/1mL) + Water (98.6 mL/100mL) Kit Ophthalmic; Oral; Respiratory (inhalation); Topical Honeywell Safety Products USA, Inc 2018-10-18 Not applicable US 4334 First Aid Kit Chloroxylenol (0.1 g/100g) + Acetaminophen (500 mg/1) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Benzocaine (5 g/100g) + Ethanol (0.5 mL/1mL) + Isopropyl alcohol (0.7 mL/1mL) + Lidocaine hydrochloride (20 mg/1mL) + Lidocaine hydrochloride (2 g/100g) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g) + Povidone-iodine (10 mg/1mL) Gel; Kit; Liquid; Ointment; Swab; Tablet Oral; Topical Honeywell Safety Products USA, Inc 2018-10-18 Not applicable US 4357 First Aid Kit Chloroxylenol (0.1 g/100g) + Bacitracin zinc (400 [iU]/1g) + Benzethonium chloride (0.2 g/100g) + Benzocaine (10 g/100g) + Benzocaine (5 g/100g) + Hydrocortisone acetate (1 g/100g) + Hydrocortisone acetate (1 g/100g) + Isopropyl alcohol (0.7 mL/1mL) + Lidocaine hydrochloride (2 g/100g) + Menthol (0.33 g/100g) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g) + Water (98.6 mL/100mL) Cream; Gel; Kit; Liquid; Ointment; Spray; Swab Ophthalmic; Topical Honeywell Safety Products USA, Inc 2018-10-18 Not applicable US 4358 First Aid Kit Chloroxylenol (0.1 g/100g) + Ammonia (0.045 g/0.3mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Benzocaine (5 g/100g) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g) + Povidone-iodine (10 mg/1mL) + Water (98.6 mL/100mL) Kit Ophthalmic; Respiratory (inhalation); Topical Honeywell Safety Products USA, Inc 2018-10-18 Not applicable US 4367 First Aid Kit Chloroxylenol (0.1 g/100g) + Ammonia (0.045 g/0.3mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Benzocaine (5 g/100g) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g) + Povidone-iodine (10 mg/1mL) + Water (98.6 mL/100mL) Kit Ophthalmic; Respiratory (inhalation); Topical Honeywell Safety Products USA, Inc 2018-10-18 Not applicable US 4379 First Aid Kit Chloroxylenol (0.1 g/100g) + Acetaminophen (500 mg/1) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Benzocaine (5 g/100g) + Ethanol (0.5 mL/1mL) + Isopropyl alcohol (0.7 mL/1mL) + Lidocaine hydrochloride (2 g/100g) + Lidocaine hydrochloride (20 mg/1mL) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g) + Povidone-iodine (10 mg/1mL) Gel; Kit; Liquid; Ointment; Swab; Tablet Oral; Topical Honeywell Safety Products USA, Inc 2018-10-18 Not applicable US Antibacterial Foam Chloroxylenol (5 mL/1000mL) Soap Topical Sanihealth Products Corporation 2010-05-18 Not applicable US Champion Ultra Clean Chloroxylenol (13 kg/100kg) Liquid Topical Morgan Gallacher Inc. Dba Custom Chemical Formulators Inc. 2020-02-06 Not applicable US Champion Ultra Clean Chloroxylenol (13 kg/100kg) Liquid Topical Maintex 2020-02-06 Not applicable US Champion Ultra Clean Fragrance and Dye Free Chloroxylenol (13 kg/100kg) Liquid Topical Maintex 2020-02-06 Not applicable US
Categories
- ATC Codes
- D08AE05 — Chloroxylenol
- Drug Categories
- Anti-Infective Agents
- Anti-Infective Agents, Local
- Antiparasitic Agents
- Antiplatyhelmintic Agents
- Antiseptics and Disinfectants
- Benzene Derivatives
- Compounds used in a research, industrial, or household setting
- Dermatologicals
- Disinfectants
- Drugs that are Mainly Renally Excreted
- Miscellaneous Local Anti-infectives
- Phenol and Derivatives
- Schistosomicides
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as meta cresols. These are aromatic compounds containing a meta-cresol moiety, which consists of a benzene ring bearing a methyl group and a hydroxyl group at ring positions 1 and 3, respectively.
- Kingdom
- Organic compounds
- Super Class
- Benzenoids
- Class
- Phenols
- Sub Class
- Cresols
- Direct Parent
- Meta cresols
- Alternative Parents
- m-Xylenes / P-chlorophenols / Chlorobenzenes / 1-hydroxy-2-unsubstituted benzenoids / Aryl chlorides / Organooxygen compounds / Organochlorides / Hydrocarbon derivatives
- Substituents
- 1-hydroxy-2-unsubstituted benzenoid / 4-chlorophenol / 4-halophenol / Aromatic homomonocyclic compound / Aryl chloride / Aryl halide / Chlorobenzene / Halobenzene / Hydrocarbon derivative / M-cresol
- Molecular Framework
- Aromatic homomonocyclic compounds
- External Descriptors
- phenols, monochlorobenzenes (CHEBI:34393)
- Affected organisms
- Humans and other mammals
Chemical Identifiers
- UNII
- 0F32U78V2Q
- CAS number
- 88-04-0
- InChI Key
- OSDLLIBGSJNGJE-UHFFFAOYSA-N
- InChI
- InChI=1S/C8H9ClO/c1-5-3-7(10)4-6(2)8(5)9/h3-4,10H,1-2H3
- IUPAC Name
- 4-chloro-3,5-dimethylphenol
- SMILES
- CC1=CC(O)=CC(C)=C1Cl
References
- General References
- McDonnell G, Russell AD: Antiseptics and disinfectants: activity, action, and resistance. Clin Microbiol Rev. 1999 Jan;12(1):147-79. [Article]
- Judis J: Binding of selected phenol derivatives to human serum proteins. J Pharm Sci. 1982 Oct;71(10):1145-7. [Article]
- ZONDEK B, FINKELSTEIN M: Blood concentration of P-chloro-xylenol in man following parenteral, percutaneous and rectal application. Proc Soc Exp Biol Med. 1946 Feb;61:200-2. [Article]
- Zondek B, Shapiro B: Fate of halogenated phenols in the organism. Biochem J. 1943;37(5):592-5. [Article]
- US EPA Reregistration Eligibility Decision (RED): Chloroxylenol [Link]
- Exponent FDA Consumer Antispetics Rule: FDA Request for Data on Safety and Efficacy of Chloroxylenol [Link]
- Electronic Medicines Compendium: Dettol (Chloroxylenol) Antiseptic Cream Monograph [Link]
- NLM Toxnet: Chloroxylenol [Link]
- Electronic Medicines Compendium: Dettol (chloroxylenol) Liquid Monograph [Link]
- External Links
- KEGG Drug
- D03473
- KEGG Compound
- C14715
- PubChem Compound
- 2723
- PubChem Substance
- 347827904
- ChemSpider
- 21106017
- BindingDB
- 50238619
- 20877
- ChEBI
- 34393
- ChEMBL
- CHEMBL398440
- ZINC
- ZINC000000001132
- Wikipedia
- Chloroxylenol
- MSDS
- Download (47.9 KB)
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 4 Completed Prevention Skin Health 1 2 Completed Treatment Cystic Fibrosis (CF) 1 Not Available Unknown Status Prevention Arthroscopic Rotator Cuff Repair / Cutibacterium Acnes 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Kit Ophthalmic; Oral; Respiratory (inhalation); Topical Cream; gel; kit; liquid; ointment; spray; swab Ophthalmic; Topical Kit Ophthalmic; Respiratory (inhalation); Topical Gel; kit; liquid; ointment; swab; tablet Oral; Topical Jelly Topical Soap Topical 1 g/100mL Liquid Topical 2.1 mL/100mL Liquid Topical 1.49 % Lotion Topical 1.0 % Soap Topical 0.005 mL/1mL Liquid Topical 15 mg/1mL Soap Topical 15 g/1000mL Solution Topical 1.5 g/100mL Gel Topical 0.01 mg/1mL Liquid Topical .3 mg/1mL Liquid Topical 0.5 % Liquid Topical 3.09 mg/1mL Liquid Topical 6.046 g/1L Soap Topical 40 g/1kg Soap Topical .3 g/100g Soap Topical 5 mL/1000mL Gel Topical 1.0 % w/w Soap Topical 6.10 g/1L Soap Topical 4 g/1000mL Liquid Topical Liquid Topical 2.5 mg/1mL Emulsion Topical 0.5 % v/v Gel Topical 10 mg/1mL Gel Topical 0.3 g/100mL Gel Topical 4 mL/800mL Lotion Topical 3.6 mg/800mL Soap Topical 6.0 mg/1000mL Liquid; soap Topical .6 % Gel Topical 0.75 g/100mL Soap Topical 0.45 g/100mL Soap Topical 10.11 g/1L Lotion Topical 0.6 % Ointment Topical 1.5 mg / g Lotion Topical 0.5 % w/w Liquid Topical 0.5 g/100mL Soap Topical 0.3 mg/100mL Soap Topical 25 g/100g Ointment Topical 8 mg / mL Solution Topical 30 mg/1mL Solution Topical 3.0 % Solution Topical 4.8 % w/v Liquid Topical 1.25 g/500mL Cream Topical .25 % Soap Cutaneous 0.1 g/100g Soap Topical 0.282 mg/100mL Liquid Cutaneous; Topical 0.2 g/100g Liquid Topical 13 kg/100kg Liquid Topical 0.3 mg/1mL Soap Topical 0.10 g/100mL Soap Topical 0.1 g/100mL Soap Topical 15 g/1L Liquid Topical 3.0 mg/1mL Solution Topical 0.6 mg/100mL Soap Topical 10.1 mg/1mL Soap Topical 5 mg/0.001L Liquid Topical 0.507 g/100mL Soap Topical 5 mg/1mL Liquid Topical 0.75 mg/100mL Liquid Topical 7.5 mg/1mL Soap Topical 0.003 g/1mL Liquid Topical 3 kg/100kg Liquid Topical 5 % Lotion Topical Liquid Topical 0.305 g/100mL Liquid Topical 0.00375 mg/1mL Kit; shampoo; soap Topical Liquid Topical 5 mg/100mL Soap Topical 0.5 g/100mL Shampoo Topical Liquid Topical 4 mg/1mL Lotion; soap Topical .5 % Liquid Topical 0.95 g/100mL Soap Topical 0.002 g/1mL Liquid Topical .6 % Solution Topical 4.8 % Liquid Topical 10 % Liquid Liquid Cutaneous 4.8 g/15mL Solution Topical 4.8 g/100mL Solution Topical 0.6 mL/100mL Liquid Topical 1 g/2L Liquid Topical 0.22 g/100mL Cloth Topical 0.2 g/100mL Liquid Topical 0.15 g/100mL Sponge Topical 3 % Liquid Topical 3 g/1L Liquid Topical 1.1 % Solution Topical 9 mg/1mL Solution Topical 1.0 mg/100mL Solution Topical 100 mg/1mL Solution Topical 5.20 mg/1mL Solution Topical 0.8 mg/100mL Lotion Topical 0.25 % Solution Topical 8 mg/1mL Lotion; soap Topical 0.8 % Liquid Topical 15.75 g/1000mL Gel Topical 2.5 mg/0.001L Solution Topical 2.5 mg/1mL Soap Topical 2.5 g/1000mL Solution Topical 0.50 % Cream Topical Solution Cutaneous Soap Topical 2 g/100L Solution Topical 10 mg/1mL Soap Topical 4.5 mg/1mL Aerosol, foam Topical Liquid Topical 0.015 g/100mL Lotion Topical .5 % Soap Topical 2.5 mg/0.001L Gel Topical 3 mg/1mL Liquid Topical 0.01 mg/1mL Liquid Topical .05 mg/1mL Solution Topical 0.3 g/100mL Liquid Topical 0.50 % Cream Soap Topical 2.5 mg/1mL Soap Topical 0.6 g/100mL Liquid Topical 0.663 g/221mL Liquid Topical 0.5 g/100g Soap Topical 3 mg/1mL Liquid Topical 3.5 g/100mL Liquid Topical 0.003 mg/1mL Liquid Topical 0.50 g/100mL Liquid Topical 1.50 g/100mL Lotion Topical 10.22 g/1000mL Solution / drops Auricular (otic) Gel Topical 0.5 % w/w Liquid Topical; Vaginal Liquid Topical 3 mg/0.001L Gel Topical 5 mg/1mL Soap Topical 3 g/1000mL Soap Topical 3 mg/1g Soap Topical 0.75 g/100mL Solution Topical 1.75 % w/w Solution Topical 17.5 g/1L Solution Topical 0.0175 L/1L Solution Topical 0.0175 g/1mL Aerosol, foam Topical 0.005 g/1mL Liquid Topical 10.22 g/1000mL Gel Topical 0.05 g/59g Solution Topical 0.5 mg/100mL Solution Topical 4.8 %w/v Liquid Topical 5 mg/1mL Gel Topical 0.95 g/1g Liquid Topical 6 mg/1mL Soap Topical 0.95 g/100mL Solution Topical 6.12 mg/1mL Cloth Topical Swab Topical Liquid Topical 0.30 g/100g Liquid Topical 0.3 % Solution Topical Gel Topical 0.015 g/100mL Gel Topical Lotion Topical .25 % Liquid Topical .5 % Liquid Auricular (otic) Cloth Topical 0.5 % Soap Topical 2.5 mg/1g Gel Topical 2.5 mg/1mL Soap Topical 25 g/1000mL Sponge Topical 33 mg/1mL Sponge Topical 40 mg/1mL Solution Topical 3.3 mg/100mL Liquid Topical 0.6 g/100g Soap Topical 0.005 g/1mL Soap Topical 0.1 g/100g Liquid Topical 0.3 g/100mL Liquid Topical 0.6657 mg/221.8mL Liquid Topical 1.5 % Solution Topical 0.6 % w/w Liquid Topical 3 mg/1mL Solution Topical 0.525 % w/w Liquid Topical 0.5 mg/100mL Liquid Topical .25 % Liquid Topical 0.30 kg/100kg Lotion Topical .6 % Solution Topical 6 mg/1mL Soap Topical 0.3 g/100mL Liquid Topical 0.5 mL/100mL Solution Topical 5 mg/1mL Solution Topical 5.2 mg/1mL Solution Topical 5.25 mg/1mL Lotion Topical .3 % Liquid Topical 0.005 mg/1mL Solution Topical 0.005 mg/1mL Soap Topical 0.2 g/100mL Soap Topical 6 mg/1mL Liquid Topical 2.949 g/100mL Liquid Topical 3 % w/v Liquid Topical 3 mL/100mL Liquid Topical 0.8 mL/100mL Lotion Topical 0.08 mg/100mL Ointment Topical Gel Topical 1 % Lotion Topical 3.0 g/100mL Soap Topical 30 mg/10mL Liquid Topical .7 % Soap Topical 5 g/1000mL Liquid Topical 0.3 mg/100mL Liquid Topical 3000 mg/1L Gel Topical 0.5 g/100g Gel Topical 0.3 g/100g Soap Topical 0.1 g/1L Soap Topical 4 mg/1mL Liquid Topical 0.1 g/100mL Liquid Topical 0.0060 mg/1mL Liquid Topical 0.0060 g/1mL Solution Topical 0.5 % w/w Solution Topical 0.5 g/100mL Solution Topical 1.75 % Solution Topical 1.25 g/100mL Solution Topical 1.25 % Liquid Topical 1.75 % Solution Topical 33 mg/1mL Solution Topical 40 mg/1mL Solution Topical 3.3 % Solution Topical 4 mg/100mL Lotion Topical 0.5 % Aerosol, foam Topical .5 mL/100mL Lotion Topical 0.3 % Liquid Topical 0.6 g/100mL Liquid Topical 5 g/1L Aerosol, foam Topical 5 mg/1mL Soap Topical 0.33 mg/1000mL Liquid Topical 1.0 % Aerosol Topical .1 % Soap Topical 10 mg/1mL Solution Topical 3.82 g/100mL Liquid Topical 0.3 mL/100mL Liquid Topical 1 g/100mL Liquid Topical 1 % w/w Solution Topical 10 g/1L Solution Topical 1 g/100mL Lotion Topical 0.51 % Soap Topical 0.001 mg/100mL Liquid Topical 1 % Liquid Topical 12.604 g/100mL Liquid Topical 10 g/1000mL Liquid Topical 10 mg/1mL Solution Topical 0.3 mg/1mL Soap Topical 3 % Liquid Topical 3 % Soap Topical 0.03 g/100mL Solution Topical 0.5 % Gel Topical .25 % Liquid Topical 2 % Gel Topical 2 mg/1mL Liquid Topical 0.05 g/100mL Soap Topical 2.75 g/100mL Solution Topical 2.75 % w/w Liquid Topical 2.75 g/100mL Liquid Topical 0.3 kg/100kg Lotion Topical 1 % Soap Topical 3.75 mg/1mL Soap Topical 0.75 g/100g Liquid Topical 50 g/1L Soap Topical 3.6 g/1mL Liquid Topical 3.09 g/1mL Liquid Topical 3.06 mg/1mL Liquid Topical 1 g/1L Gel Topical 0.52 g/100mL Solution Topical 0.52 % Gel Topical 0.5 % Cloth Topical 0.5 g/100g Liquid Topical 0.6 % Liquid Topical 0.65 % Solution Topical 0.5 % v/v Solution Topical 1.2 g/240mL Solution Topical Soap Topical 2.5 g/1L Soap Topical 1 g/1L Soap Topical 1 g/100g Soap Topical 7.5 mg/1mL Soap Topical 5.0 mg/1mL Liquid Topical 2081980 mg/208198mL Soap Topical .5 % Soap Topical Liquid Topical 3 g/100mL Liquid Topical 0.4 g/100mL Liquid Topical 0.04 g/10L Liquid Topical 0.3 g/10mL Liquid; shampoo Topical - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Liquid
- Experimental Properties
Property Value Source melting point (°C) 112-116 degrees Celsius MSDS boiling point (°C) 246 degrees Celsius MSDS water solubility 0.03 g/100ml at 15 degrees Celsius, 0.5 g/100ml at 100 degrees Celsius MSDS - Predicted Properties
Property Value Source Water Solubility 0.855 mg/mL ALOGPS logP 3.14 ALOGPS logP 3.3 Chemaxon logS -2.3 ALOGPS pKa (Strongest Acidic) 9.21 Chemaxon pKa (Strongest Basic) -6.3 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 1 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 20.23 Å2 Chemaxon Rotatable Bond Count 0 Chemaxon Refractivity 42.93 m3·mol-1 Chemaxon Polarizability 16.04 Å3 Chemaxon Number of Rings 1 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Mass Spectrum (Electron Ionization) MS splash10-05fu-9500000000-8bba3165beb98d883986 Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS Not Available 1H NMR Spectrum 1D NMR Not Applicable 13C NMR Spectrum 1D NMR Not Applicable
Drug created at December 03, 2015 16:51 / Updated at November 28, 2023 22:14