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Homeodomain-interacting protein kinase 2
go.drugbank.com/bio_entities/BE0009447TargetHumansSerine/threonine-protein kinase involved in transcription regulation, p53/TP53-mediated cellular apoptosis and regulation of the cell cycle. Acts as a corepressor of several transcription factors, including SMAD1 and POU4F1/Brn3a and pro...
Polypeptides: Homeodomain-interacting protein kinase 2Interleukin-1 receptor-like 2
go.drugbank.com/bio_entities/BE0010198TargetHumansReceptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAP...
Polypeptides: Interleukin-1 receptor-like 2Synonyms: Interleukin-1 receptor-related protein 2NPC intracellular cholesterol transporter 2
go.drugbank.com/bio_entities/BE0010359TransporterHumansIntracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment (PubMed:11125141, PubMed:15937921, PubMed:17018531, PubMed:18772377, PubMed:295...
Polypeptides: NPC intracellular cholesterol transporter 2DNA polymerase subunit gamma-2
go.drugbank.com/bio_entities/BE0010885TargetHumansAccessory subunit of DNA polymerase gamma solely responsible for replication of mitochondrial DNA (mtDNA). Acts as an allosteric regulator of the holoenzyme activities. Enhances the polymerase activity and the processivity of POLG by inc...
Polypeptides: DNA polymerase subunit gamma-2Fructose-1,6-bisphosphatase isozyme 2
go.drugbank.com/bio_entities/BE0011215TargetEnzymeHumansCatalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations and probably participates in glycogen synthesis from carbohydrate precursors, such as lactate
Polypeptides: Fructose-1,6-bisphosphatase isozyme 2Synonyms: FBPase 2, D-fructose-1,6-bisphosphate 1-phosphohydrolase 2Eukaryotic elongation factor 2 kinase
go.drugbank.com/bio_entities/BE0011325TargetHumansThreonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. Upon activation by a variety of upstream kinases including AMPK or TRPM7, phosphorylates the elongation factor EEF2 at a single site, ...
Polypeptides: Eukaryotic elongation factor 2 kinaseSynonyms: eEF-2 kinase, Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinaseSphingosine 1-phosphate receptor 2
go.drugbank.com/bio_entities/BE0012208TargetHumansReceptor for the lysosphingolipid sphingosine 1-phosphate (S1P) (PubMed:10617617, PubMed:25274307). S1P is a bioactive lysophospholipid that elicits diverse physiological effects on most types of cells and tissues (PubMed:10617617). When...
Polypeptides: Sphingosine 1-phosphate receptor 2Synonyms: S1P receptor 2, S1P receptor Edg-5N-formyl peptide receptor 2
go.drugbank.com/bio_entities/BE0012843TargetHumansPattern recognition G protein-coupled receptor (GPCR) that recognizes peptides with N-terminal formyl methionine, which are derived from invading pathogens or host mitochondria as pathogen or damage-associated molecular patterns (PAMPs a...
Polypeptides: N-formyl peptide receptor 2Transmembrane channel-like protein 2
go.drugbank.com/bio_entities/BE0017488TargetHumansPore-forming subunit of the mechanotransducer (MET) non-selective cation channel complex located at the tips of stereocilia of cochlear hair cells and that mediates sensory transduction in the auditory system (PubMed:11850618). The MET c...
Polypeptides: Transmembrane channel-like protein 2Synonyms: Transmembrane cochlear-expressed protein 2Insulin-induced gene 2 protein
go.drugbank.com/bio_entities/BE0021304TargetHumansOxysterol-binding protein that mediates feedback control of cholesterol synthesis by controlling both endoplasmic reticulum to Golgi transport of SCAP and degradation of HMGCR (PubMed:12242332, PubMed:16606821, PubMed:32322062). Acts as ...
Polypeptides: Insulin-induced gene 2 proteinSynonyms: INSIG-2