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Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
go.drugbank.com/bio_entities/BE0005530TargetHumansDephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion formation (PubMed:22279049). … In motile cells, suppresses the formation of lateral pseudopods and thereby promotes cell polarization and directed movement (PubMed:22279049).
Polypeptides: Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTENSynonyms: Phosphatase and tensin homologSolute carrier family 12 member 5
go.drugbank.com/bio_entities/BE0009674TransporterMouseMediates electroneutral potassium-chloride cotransport in mature neurons and is required for neuronal Cl(-) homeostasis (By similarity). … As major extruder of intracellular chloride, it establishes the low neuronal Cl(-) levels required for chloride influx after binding of GABA-A and glycine to their receptors, with subsequent hyperpolarization
Synonyms: Electroneutral potassium-chloride cotransporter 2Cystic fibrosis transmembrane conductance regulator
go.drugbank.com/bio_entities/BE0001195TargetTransporterHumansPlays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation (PubMed:19923167, PubMed:27714810, PubMed:29393851) … May regulate bicarbonate secretion and salvage in epithelial cells by regulating the transporter SLC4A7 (PubMed:12403779). Can inhibit the chloride channel activity of ANO1 (PubMed:22178883).
Synonyms: cAMP-dependent chloride channelHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A
go.drugbank.com/bio_entities/BE0003717TargetHumansProtects against cell death induced by hydrogen peroxide and staurosporine (PubMed:23509299) … May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development (PubMed:18983167).
Polypeptides: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8ASolute carrier family 12 member 1
go.drugbank.com/bio_entities/BE0000502TargetTransporterHumansRenal sodium, potassium and chloride non-electrogenic ion symporter that mediates the transepithelial NaCl reabsorption in the thick ascending limb and plays an essential role in the urinary concentration … and volume regulation (PubMed:21321328).
Synonyms: Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1Solute carrier family 12 member 2
go.drugbank.com/bio_entities/BE0000281TargetTransporterHumansCation-chloride cotransporter which mediates the electroneutral transport of chloride, potassium and/or sodium ions across the membrane (PubMed:16669787, PubMed:32081947, PubMed:32294086, PubMed:33597714 … Plays a vital role in the regulation of ionic balance and cell volume (PubMed:16669787, PubMed:32081947, PubMed:32294086, PubMed:7629105)
Synonyms: Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1
go.drugbank.com/bio_entities/BE0018277TargetHumansIs also an important negative regulator of oligodentrocyte differentiation and axonal myelination (PubMed:15895088). … Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development (By similarity)
Polypeptides: Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1Synonyms: Leucine-rich repeat and immunoglobulin domain-containing protein 1Adiponectin receptor
go.drugbank.com/bio_entities/BE0010287TargetHumansRequired for normal glucose and fat homeostasis and for maintaining a normal body weight. … Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed:12802337, PubMed:25855295). Required for normal body fat and glucose homeostasis.
Synonyms: Progestin and adipoQ receptor family member 1, Progestin and adipoQ receptor family member IImmunoglobulin J chain
go.drugbank.com/bio_entities/BE0009083TargetHumansIn the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces dimers and/or larger polymers.
Synonyms: Joining chain of multimeric IgA and IgMProlyl 3-hydroxylase OGFOD1
go.drugbank.com/bio_entities/BE0002210TargetHumansProlyl 3-hydroxylase that catalyzes 3-hydroxylation of 'Pro-62' of small ribosomal subunit uS12 (RPS23), thereby regulating protein translation termination efficiency. Involved in stress granule formation
Synonyms: Termination and polyadenylation 1 homolog, 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1