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Sufentanil Action Pathway
smpdb.ca/view/SMP0000417Drug actionand decrease in cAMP production. … It also inhibits nociceptive neurotransmitter release and induces membrane hyperpolarization. Analgesia, anesthesia, and respiratory depression are a consequence of remifentanial’s action.
Enzymes: Sodium channel subunit beta-1, Sodium-dependent serotonin transporterPropoxyphene Action Pathway
smpdb.ca/view/SMP0000672Drug actionOpioids inhibit vasopressin, somatostatin, insulin and glucagon release. … Propoxyphene also causes the closure of voltage-gated calcium channels and opens potassium channels causing the hyperpolarization of the membrane and decreasing neuronal excitability.
Enzymes: Sodium channel subunit beta-1, Sodium-dependent serotonin transporterLevorphanol Action Pathway
smpdb.ca/view/SMP0000673Drug actionThe binding of levorphanol will eventually lead to reduced pain because of decreased nerve conduction and release of neurotransmitter. … Therefore, levorphanol can reduce nerve conduction and decrease neurotransmitter release; so that perception of pain signals can be blocked.
Enzymes: Sodium channel subunit beta-1, Sodium-dependent serotonin transporterAnileridine Action Pathway
smpdb.ca/view/SMP0000674Drug actionThe binding of anileridine will eventually lead to reduced pain because of decreased nerve conduction and release of neurotransmitter. … Hyperpolarization of neuron is caused by inactivation of calcium channels and activation of potassium channels via facilitated by G-protein.
Enzymes: Sodium channel subunit beta-1, Sodium-dependent serotonin transporterMethadyl Acetate Action Pathway
smpdb.ca/view/SMP0000678Drug actionThe binding of methadyl acetate will eventually lead to reduced pain because of decreased nerve conduction and release of neurotransmitter. … Therefore, methadyl acetate can reduce nerve conduction and decrease neurotransmitter release; so that perception of pain signals can be blocked.
Enzymes: Sodium channel subunit beta-1, Sodium-dependent serotonin transporterEthylmorphine Action Pathway
smpdb.ca/view/SMP0000681Drug actionMorphine can also bind and inhibit gamma-Aminobutyric acid (GABA) inhibitory interneurons. … Ethylmorphine (also known as codethyline and dionine) is an opioid analgesic. Ethylmorphine can be metabolized to form morphine by cytochrome P450 2D6 (CYP2D6).
Enzymes: Sodium channel subunit beta-1, Sodium-dependent serotonin transporterPentazocine Action Pathway
smpdb.ca/view/SMP0000686Drug actionBinding of pentazocine on mu-type opioid receptor and kappa-type opioid receptor can lead to decreased level of neuronal excitability and hyperpolarization. … Pentazocine can bind to mu-type opioid receptor and kappa-type opioid receptor on neuron of central nerves system (CNS).
Enzymes: Sodium channel subunit beta-1, Sodium-dependent serotonin transporterHeroin Action Pathway
smpdb.ca/view/SMP0000407Drug actionThey are beta-endorphin, dynorphin, leu-enkephalin, and met-enkephalin. … Endorphins are regularly released in the brain and nerves, attenuating pain.
Enzymes: Sodium channel subunit beta-1, Sodium-dependent serotonin transporterOxycodone Action Pathway
smpdb.ca/view/SMP0000409Drug actionThe binding of oxycodone will eventually lead to reduced pain because of decreased nerve conduction and release of neurotransmitter. … Hyperpolarization of neuron is caused by inactivation of calcium channels and activation of potassium channels via facilitated by G-protein.
Enzymes: Sodium channel subunit beta-1, Sodium-dependent serotonin transporterFentanyl Action Pathway
smpdb.ca/view/SMP0000415Drug actionThe binding of carfentanil will eventually lead to reduced pain because of decreased nerve conduction and release of neurotransmitter. … Hyperpolarization of neuron is caused by inactivation of calcium channels and activation of potassium channels via facilitated by G-protein.
Enzymes: Sodium channel subunit beta-1, Sodium-dependent serotonin transporter